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Immune Chemistry of ASA

  • Maciej KurpiszEmail author
  • Marzena Kamieniczna
  • Karolina Nowicka-Bauer
Chapter

Abstract

Immune chemistry of ASA encompasses all the types of antisperm antibody reactions in humans that are ontogenically driven by (a) ‘natural’ antibodies, (b) pre-pubertally derived ASA due to testicular failure, (c) adult ASA in males and females, and (d) carbohydrate-mediated epitopes. Both sexes (with exception of boys before puberty) present active immune tolerance to male gametes which allows to resume a natural intercourse as well as permanent gamete differentiation in spermatogenesis. ‘Natural’ antibodies are developed as a part of immune history of the individual but they are also essential elements of innate immunity in both sexes. ASA developed before puberty are well characterized by proteomic approach and deserve more attention. ASA reactions in males and females are fairly well studied while carbohydrate-mediated chemistry of ASA activity is still a complex issue under study.

Keywords

Molecular Mimicry Western Immunoblotting Premature Ovarian Failure Undescendent Testis Female Reproductive Tract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  • Maciej Kurpisz
    • 1
    Email author
  • Marzena Kamieniczna
    • 1
  • Karolina Nowicka-Bauer
    • 2
  1. 1.Department of Reproductive Biology and Stem CellsInstitute of Human Genetics, Polish Academy of SciencesPoznanPoland
  2. 2.Institute of Human Genetics, Polish Academy of SciencesPoznanPoland

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