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Impact on Fertility Outcome

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Immune Infertility

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Abstract

Autoimmune and/or isoimmune infertility can be caused also by sperm antibodies, which are able to stop in vitro and in vivo sperm progressive penetration needed for fertility. This chapter covers all aspects concerning male and female antibody and cellular immunological disorders to spermatozoa complicating human fertility, and possible ways of the treatment. Regarding the incidence of sperm antibodies in an infertile population, which is 9 % of the men and 15 % of the women, it is necessary to define significant sperm antigens for desensitization of immunological infertility and/or for development of contraceptive treatment.

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Acknowledgment

This work was supported by the Charles University Research Fund (project number P36).

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Authors and Affiliations

  1. Reproductive Immunology and Gynecology, Genetics-Pilsen, and Department of Gynecology and Obstetrics of Medical Faculty of Charles University Pilsen, Parkova 1254/IIA, Pilsen, 326 00, Czech Republic

    Zdenka Ulcova-Gallova

  2. Genetics-Pilsen, Gynecology, Pilsen, Parkova 1254/IIA, Pilsen, 326 00, Czech Republic

    Petr Losan

Authors
  1. Zdenka Ulcova-Gallova
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  2. Petr Losan
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Correspondence to Zdenka Ulcova-Gallova .

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Editors and Affiliations

  1. Department of Dermatology and Allergology, University Hospital, Philipp University, Marburg, Germany

    Walter K.H. Krause

  2. Department of Obstetrics and Gynecology, School of Medicine, West Virgina University, Morgantown, USA

    Rajesh K. Naz

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Ulcova-Gallova, Z., Losan, P. (2017). Impact on Fertility Outcome. In: Krause, W., Naz, R. (eds) Immune Infertility. Springer, Cham. https://doi.org/10.1007/978-3-319-40788-3_14

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  • DOI: https://doi.org/10.1007/978-3-319-40788-3_14

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40786-9

  • Online ISBN: 978-3-319-40788-3

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