Modulation by Histamine H3 Receptors of Neurotransmitter Release in the Basal Ganglia

  • Ricardo Márquez-Gómez
  • Ana-Maricela García-Gálvez
  • Guadalupe-Elide Morales-Figueroa
  • José-Antonio Arias-MontañoEmail author
Part of the The Receptors book series (REC, volume 28)


Among the four G-protein coupled receptors (H1-H4 ) identified as the mediators of the biological effects of histamine, the H3 receptor (H3R) distinguishes for its almost exclusive expression in the nervous system and its dual function as auto- and hetero-receptor that enables H3Rs to modulate the histaminergic and other neurotransmitter systems. The basal ganglia are neuronal nuclei that form a sub-cortical circuitry responsible for integrating motor and sensorial information originated in the cerebral cortex and the thalamus. The abundant presence of H3Rs in the basal ganglia confers these receptors a preferential and strategic position to modulate both the incoming and the outgoing synaptic information. In this chapter we review the control by H3Rs of the release of the neurotransmitters involved in the basal ganglia circuitry.


Acetylcholine Basal ganglia Calcium channels Cerebral cortex Central nervous system GABA G protein-coupled receptors Dopamine Globus pallidus Glutamate Histamine Histamine H3 receptors Hypothalamus Neurotransmitter release Neuromodulation Noradrenaline Serotonin (5-Hydroxytryptamine) Striatum Substantia nigra Subthalamic nucleus Thalamus 



5-Hydroxytryptamine (serotonin)


Adenosine A1 receptor


Adenosine A2A receptor


Basal ganglia


Central nervous system


Dopamine D1-like receptor


Dopamine D2-like receptor


Excitatory postsynaptic currents


Field potential


γ-Aminobutyric acid


G protein-gated inwardly rectifying K+ channel


Globus pallidus


G protein-coupled receptor


Histamine H1 receptor


Histamine H2 receptor


Histamine H3 receptor


Histamine H4 receptor


Histidine decarboxylase


Inhibitory postsynaptic currents


Medium-sized spiny neuron


Protein kinase A


Protein kinase C


Phospholipase C


Raphe nuclei


Substantia nigra


Substantia nigra pars compacta


Substantia nigra pars reticulata


Subthalamic nucleus


Tyrosine hydroxylase


Tuberomammillary nucleus



Research in our laboratory is supported by Cinvestav and the Mexican Council for Science and Technology (Conacyt).


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Ricardo Márquez-Gómez
    • 1
  • Ana-Maricela García-Gálvez
    • 1
  • Guadalupe-Elide Morales-Figueroa
    • 1
  • José-Antonio Arias-Montaño
    • 1
    Email author
  1. 1.Departamento de FisiologíaBiofísica y Neurociencias, Centro de Investigación y de Estudios Avanzados del IPNCiudad de MéxicoMexico

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