Cardiac Malignancies: Clinical Aspects



Most cardiac tumors are clinically silent and are diagnosed only postmortem. If present, symptoms that are nonspecific can be distinguished with difficulty from other causes of cardiovascular disease and are known to be “great mimickers” [1]. One of the most important problems concerning to the diagnosis of cardiac tumors is the lack of specific signs and symptoms. The clinical manifestations of cardiac metastases mainly depend on the size and anatomical location of the tumor, rather than on its histological type. The symptoms of cardiac metastases can be grouped into the following major categories [2–7]:


  1. 1.
    Butany J, Nair V, Naseemuddin A, Nair GM, Catton C, Yau T. Cardiac tumours: diagnosis and management. Lancet Oncol. 2005;6:219–28.CrossRefPubMedGoogle Scholar
  2. 2.
    Goldberg AD, Blankstein R, Padera RF. Tumour metastatic to the heart. Circulation. 2013;128:1790–4.CrossRefPubMedGoogle Scholar
  3. 3.
    Neragi-Miandoab S, Kim J, Vlahakes GJ. Malignant tumours of the heart: a review of tumour type, diagnosis and therapy. Clin Oncol (R Coll Radiol). 2007;19:748–56.CrossRefGoogle Scholar
  4. 4.
    Hudzik B, Miszalski-Jamka K, Glowacki J, Lekston A, Gierlotka M. Malignant tumors of the heart. Cancer Epidemiol. 2015;39:665–72.Google Scholar
  5. 5.
    Perazzolo Marra M, Thiene G, De Lazzari M, et al. Concealed metastatic lung carcinoma presenting as acute coronary syndrome with progressive conduction abnormalities. Circulation. 2012;125:e499–502.CrossRefPubMedGoogle Scholar
  6. 6.
    Bussani R, De-Giorgio F, Abbate A, Silvestri F. Cardiac metastases. J Clin Pathol. 2007;60:27–34.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Reynen K, Köckeritz U, Strasser RH. Metastases to the heart. Ann Oncol. 2004;15:375–81.CrossRefPubMedGoogle Scholar
  8. 8.
    Di Michele S, Mirabelli F, Galzerano D, Mankad S. An unusual myocardial infarction. Echo Res Prac. 2014;1:K9–12.CrossRefGoogle Scholar
  9. 9.
    Angeli D, Angeli SJ. Respiratory failure in an adolescent with primary cardiac sarcoma. Case Rep Cardiol. 2015;2015, 592385.PubMedPubMedCentralGoogle Scholar
  10. 10.
    Huang G, Shu L, Xu J. Heart failure and main pulmonary artery obstruction caused by right ventricular metastatic adult hepatoblastoma: a case report. Medicine (Baltimore). 2015;94, e1535.CrossRefGoogle Scholar
  11. 11.
    Lestuzzi C, Nicolosi GL, Biasi S, Piotti P, Zanuttini D. Sensitivity and specificity of electrocardiographic ST-T changes as markers of neoplastic myocardial infiltration. Echocardiographic correlation. Chest. 1989;95:980–5.CrossRefPubMedGoogle Scholar
  12. 12.
    Abe S, Watanabe N, Ogura S, et al. Myocardial metastasis from primary lung cancer: myocardial infarction-like ECG changes and pathologic findings. Jpn J Med. 1991;30:213–8.CrossRefPubMedGoogle Scholar
  13. 13.
    Pan KL, Wu LS, Chung CM, et al. Misdiagnosis: cardiac metastasis presented as a pseudo-infarction on electrocardiography. Int Heart J. 2007;48:399–405.CrossRefPubMedGoogle Scholar
  14. 14.
    Argula RG, Negi SI, Banchs J, Yusuf SW. Role of a 12-lead electrocardiogram in the diagnosis of cardiac tamponade as diagnosed by transthoracic echocardiography in patients with malignant pericardial effusion. Clin Cardiol. 2015;38:139–44.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Cardiology Unit and Coronary Intensive Care UnitOspedale San Camillo-ForlaniniRomeItaly
  2. 2.Cardiology UnitIRCCS CRO-National Cancer InstituteAviano (PN)Italy

Personalised recommendations