Skip to main content
SpringerLink
Log in

Endocrine System and Cardiovascular Disease

  • Chapter
  • First Online:
Integrative Cardiology

Abstract

The Endocrine System play a pivotal role in the regulation of Cardiovascular System, thus regulating many of its activities. Hormones are active on hearth rate, ventricular contraction, blood pressure and body fluid rgulation, not only at periferal level but also on lung circulation. Endocrine dysfunction may have a significant impact on the cardiovascular function. Restoration of normal endocrine activity often results in reversal of adverse cardiovascular changes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Schade R, Andersohn F, Suissa S, Haverkamp W, Garbe E (2007) Dopamine agonists and the risk of cardiac-valve regurgitation. N Engl J Med 356:29–38

    Article  CAS  PubMed  Google Scholar 

  2. Vitale G, Pivonello R, Lombardi G, Colao A (2004) Cardiac abnormalities in acromegaly. Pathophysiology and implications for management. Treat Endocrinol 3(5):309–318

    Article  PubMed  Google Scholar 

  3. Attanasio AF, Do M, Erfurth EM, Tan M, Ho KY, Kleinberg D et al (2010) Prevalence of metabolic syndrome in adult hypopituitary growth hormone (GH)-deficient patients before and after GH replacement. J Clin Endocrinol Metab 95:74–81

    Article  CAS  PubMed  Google Scholar 

  4. Faggiano A, Pivonello R, Spiezia S, De Martino MC, Fillippella M, Di Somma C et al (2003) Cardiovascular risk factors and common carotid artery caliber and stiffness in patients with Cushing’s disease during active disease and 1 year after disease remission. J Clin Endocrinol Metab 88:2527–2533

    Article  CAS  PubMed  Google Scholar 

  5. Kahaly GJ, Dillman WH (2005) Thyroid hormone action in the heart. Endocr Rev 26:704–728

    Article  CAS  PubMed  Google Scholar 

  6. Klein I, Danzi S (2007) Thyroid disease and the heart. Circulation 116:1725–1735

    Article  PubMed  Google Scholar 

  7. Northcote RJ, MacFarlane P, Kesson CM, Ballantyne D (1986) Continuous 24-hour electrocardiography in thyrotoxicosis before and after treatment. Am Heart J 112:339–344

    Article  CAS  PubMed  Google Scholar 

  8. Biondi B, Klein I (2004) Hypothyroidism as a risk factor for cardiovascular disease. Endocrine 24:1–13

    Article  CAS  PubMed  Google Scholar 

  9. Fazio S, Palmieri EA, Lombardi G, Biondi B (2004) Effects of thyroid hormone on the cardiovascular system. Recent Prog Horm Res 59:31–50

    Article  CAS  PubMed  Google Scholar 

  10. Irwin Klein MD, Danzi S (2007) Thyroid disease and the heart. Circulation 116:1725–1735

    Article  PubMed  Google Scholar 

  11. Naderi N, Heidarali M, Barzegari F, Ghadrdoost B, Amin A, Taghavi S (2015) Hormonal profile in patients with dilated cardiomyopathy. Res Cardiovasc Med 4(3):e27631

    Article  PubMed  PubMed Central  Google Scholar 

  12. Qari A (2015) Thyroid hormone profile in patients with acute coronary syndrome. Iran Red Crescent Med J 17(7):e26919

    Google Scholar 

  13. Barbesino G (2010) Drugs affecting thyroid function. Thyroid 20:763–770

    Article  PubMed  Google Scholar 

  14. Galetta F, Bernini G, Franzoni F, Bacca A, Fivizzani I, Tocchini L (2009) Cardiac remodeling in patients with primary aldosteronism. J Endocrinol Invest 32:739–745

    Article  CAS  PubMed  Google Scholar 

  15. Rizzoni D, Paiardi S, Rodella L, Porteri E, De Ciuceis C, Rezzani R et al (2006) Changes in extracellular matrix in subcutaneous small resistance arteries of patients with primary aldosteronism. J Clin Endocrinol Metab 91:2638–2642

    Article  CAS  PubMed  Google Scholar 

  16. Galetta F, Franzoni F, Bernini G, Poupak F, Carpi A, Cini G et al (2010) Cardiovascular complications in patients with pheochromocytoma: a mini-review. Biomed Pharmacother 64:505–509

    Article  CAS  PubMed  Google Scholar 

  17. Donahoe SM, Stewart GC, McCabe CH et al (2007) Diabetes and mortality following acute coronary syndromes. JAMA 298:765–775

    Article  CAS  PubMed  Google Scholar 

  18. Aronson D, Edelman ER (2016) Coronary artery disease and diabetes mellitus. Heart Fail Clin 12(1):117–133

    Article  PubMed  Google Scholar 

  19. Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, Raskin P, Zinman B, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group (2005) Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 353(25):2643–2653

    Article  PubMed  Google Scholar 

  20. Aronson D, Edelman ER (2014) Coronary artery disease and diabetes mellitus. Cardiol Clin 32(3):439–455

    Article  PubMed  PubMed Central  Google Scholar 

  21. Yakubovich N, Gerstein HC (2011) Serious cardiovascular outcomes in diabetes: the role of hypoglycemia. Circulation 123:342–348

    Article  PubMed  Google Scholar 

  22. Mannucci E, Dicembrini I, Lauria A, Pozzilli P (2013) Is glucose control important for prevention of cardiovascular disease in diabetes? Diabetes Care 36[Suppl 2]:S259–S263

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Pfeffer MA, Claggett B, Diaz R, Dickstein K, Gerstein HC, Køber LV, Lawson FC, Ping L, Wei X, Lewis EF, Maggioni AP, McMurray JJ, Probstfield JL, Riddle MC, Solomon SD, Tardif JC, ELIXA Investigators (2015) Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med 373(23):2247–2257

    Article  CAS  PubMed  Google Scholar 

  24. Son JW, Kim S (2015) Dipeptidyl peptidase 4 inhibitors and the risk of cardiovascular disease in patients with type 2 diabetes: a tale of three studies. Diabetes Metab J 39(5):373–383

    Article  PubMed  PubMed Central  Google Scholar 

  25. Zinman B, Wanner C, Lachin JM, EMPAREGOUTCOME Investigators et al (2015) Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med; 374(11):1094

    Google Scholar 

  26. World Health Organization. Fact Sheet No. 311. Available from: http://www.who.int/mediacentre/factsheets/fs311/en/index.html

  27. Romero-Corral A, Montori VM, Somers VK, Korinek J, Thomas RJ, Allison TG, Mookadam F, Lopez-Jimenez F (2006) Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet 368:666–678

    Article  PubMed  Google Scholar 

  28. McGee DL (2005) Body mass index and mortality: a meta-analysis based on person-level data from twenty-six observational studies. Ann Epidemiol 15:87–97

    Article  PubMed  Google Scholar 

  29. Flegal KM, Graubard BI, Williamson DF, Gail MH (2007) Cause-specific excess deaths associated with underweight, overweight, and obesity. JAMA 298:2028–2037

    Article  CAS  PubMed  Google Scholar 

  30. Yusuf S, Hawken S, Ounpuu S, Bautista L, Franzosi MG, Commerford P, Lang CC, Rumboldt Z, Onen CL, Lisheng L et al (2005) Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case–control study. Lancet 366:1640–1649

    Article  PubMed  Google Scholar 

  31. Price GM, Uauy R, Breeze E, Bulpitt CJ, Fletcher AE (2006) Weight, shape, and mortality risk in older persons: elevated waist-hip ratio, not high body mass index, is associated with a greater risk of death. Am J Clin Nutr 84:449–460

    CAS  PubMed  Google Scholar 

  32. Romero-Corral A, Somers VK, Sierra-Johnson J, Thomas RJ, Collazo-Clavell ML, Korinek J, Allison TG, Batsis JA, Sert-Kuniyoshi FH, Lopez-Jimenez F (2008) Accuracy of body mass index in diagnosing obesity in the adult general population. Int J Obes (Lond) 32:959–966

    Article  CAS  Google Scholar 

  33. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002) Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 106(25):3143–3421

    Google Scholar 

  34. Ouchi N, Parker JL, Lugus JJ, Walsh K (2011) Adipokines in inflammation and metabolic disease. Nat Rev Immunol 11(2):85–97

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Pedersen L, Hojman P (2012) Muscle-to-organ cross talk mediated by myokines. Adipocyte 1(3):164–167

    Article  PubMed  PubMed Central  Google Scholar 

  36. Rotella CM, Dicembrini I (2015) Measurement of body composition as a surrogate evaluation of energy balance in obese patients. World J Methodol 5(1):1–9

    Article  PubMed  PubMed Central  Google Scholar 

  37. Ruige JB, Ouwens DM, Kaufman JM (2013) Beneficial and adverse effects of testosterone on the cardiovascular system in men. J Clin Endocrinol Metab 98(11):4300–4310

    Article  CAS  PubMed  Google Scholar 

  38. Shores MM, Smith NL, Forsberg CW, Anawalt BD, Matsumoto AM (2012) Testosterone treatment and mortality in men with low testosterone levels. J Clin Endocrinol Metab 97:2050–2058

    Article  CAS  PubMed  Google Scholar 

  39. Muraleedharan V, Marsh H, Kapoor D, Channer KS, Jones TH (2013) Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes. Eur J Endocrinol 169:725–733

    Article  CAS  PubMed  Google Scholar 

  40. Corona G, Maseroli E, Rastrelli G, Isidori AM, Sforza A et al (2014) Cardiovascular risk associated with testosterone-boosting medications: a systematic review and meta-analysis. Expert Opin Drug Saf 13:1327–1351

    Article  CAS  PubMed  Google Scholar 

  41. The ESHRE Capri Workshop Group (2006) Hormones and cardiovascular health in women. Hum Reprod Update 12:483–497

    Article  Google Scholar 

  42. Stevenson JC (2011) A woman’s journey through the reproductive, transitional and postmenopausal periods of life: impact on cardiovascular and musculo-skeletal risk and the role of estrogen replacement. Maturitas 70(2):197–205

    Article  PubMed  Google Scholar 

  43. Baksu B, Davas I, Agar E et al (2007) Do different delivery systems of estrogen therapy influence serum lipids differently in surgically menopausal women? J Obstet Gynaecol Res 33:346–352

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biomedical, Experimental and Clinical Sciences, University of Florence Medical School, Florence, Italy

    Carlo Maria Rotella, Ilaria Dicembrini & Laura Pala

Authors
  1. Carlo Maria Rotella
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ilaria Dicembrini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Laura Pala
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Carlo Maria Rotella .

Editor information

Editors and Affiliations

  1. Department of Nuclear Physics, Guglielmo Marconi University, Rome, Italy

    Massimo Fioranelli

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Rotella, C.M., Dicembrini, I., Pala, L. (2017). Endocrine System and Cardiovascular Disease. In: Fioranelli, M. (eds) Integrative Cardiology. Springer, Cham. https://doi.org/10.1007/978-3-319-40010-5_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-40010-5_8

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40008-2

  • Online ISBN: 978-3-319-40010-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation