Abstract
The previous chapter laid the foundation for a solid understanding of kinetics. The next learning objective is to connect what has been learned thus far to metabolic regulation. To do this it is necessary to learn how enzymes operate. Enzymes are the mediators of biochemical reactions and their catalytic action is underpinned by kinetics.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Cornish-Bowden, A., and A. Cornish-Bowden. 2012. Fundamentals of enzyme kinetics, vol. 510. Weinheim, Germany: Wiley-Blackwell.
Ganguly, P., and S.F. Alam. 2015. Role of homocysteine in the development of cardiovascular disease. Nutrition Journal 14: 6.
He, L., and Y. Shen. 2017. MTHFR C677T polymorphism and breast, ovarian cancer risk: A meta-analysis of 19,260 patients and 26,364 controls. OncoTargets and Therapy 10: 227–238.
Roostaei, T., et al. 2018. Genetic influence of plasma homocysteine on Alzheimer’s disease. Neurobiology of Aging 62: 243.e7–243.e14.
Benkovic, S.J., and S. Hammes-Schiffer. 2003. A perspective on enzyme catalysis. Science 301 (5637): 1196–1202.
Michaelis, L., et al. 2011. The original Michaelis constant: Translation of the 1913 Michaelis-Menten paper. Biochemistry 50 (39): 8264–8269.
Cornish-Bowden, A. 2013. The origins of enzyme kinetics. FEBS Letters 587 (17): 2725–2730.
Cornish-Bowden, A. 2015. One hundred years of Michaelis-Menten kinetics. Perspectives in Science 4: 3–9.
Keleti, T. 1986. Two rules of enzyme kinetics for reversible Michaelis-Menten mechanisms. FEBS Letters 208 (1): 109–112.
Chaplin, M.F. and C. Bucke. 1990. Enzyme technology. CUP Archive.
Cornish-Bowden, A., Principles of enzyme kinetics. 2014: Elsevier.
Weiss, J.N. 1997. The Hill equation revisited: Uses and misuses. Faseb j 11 (11): 835–841.
Hill, A.V. 1910. The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. The Journal of Physiology (London) 40: 4–7.
Bhaskaran, S., U. P., and A.S. Nair. 2015. Hill equation in modeling transcriptional regulation. In Systems and synthetic biology, ed. V. Singh and P.K. Dhar, 77–92. Dordrecht: Springer Netherlands.
Tyson, J.J., K.C. Chen, and B. Novak. 2003. Sniffers, buzzers, toggles and blinkers: Dynamics of regulatory and signaling pathways in the cell. Current Opinion in Cell Biology 15 (2): 221–231.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Mc Auley, M.T. (2019). Enzyme Kinetics. In: Computer Modelling for Nutritionists. Springer, Cham. https://doi.org/10.1007/978-3-319-39994-2_3
Download citation
DOI: https://doi.org/10.1007/978-3-319-39994-2_3
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-39992-8
Online ISBN: 978-3-319-39994-2
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)