Abstract
The observation that chronic disorders occur together frequently has become of increasing interest as it is now viewed as the norm and not the exception. Of concern is the increasing trend of comorbidity in younger populations especially in areas of socioeconomic deprivation and low income countries. There are reasons why comorbidity is of great importance not only in the context of diagnostic classification, aetiology and pathogenesis but also for models of health-care delivery, rationalisation of pharmacotherapy, patients’ self management and the complex simultaneous utilisation of health-care systems. There is a need, therefore, for a better understanding of the coexistence of various diseases in order to develop more effective and cost-effective interventions to improve health and social outcomes. Comorbidity in medicine is now viewed as one of the major challenges in the twenty-first century in terms of prevention and treatment. With comorbidity comes the increasing risk of mental health problems especially depression leading to potentially more complications and worse prognosis overall. It is already well established that those with severe mental illness suffer increased comorbid conditions and a reduced life expectancy due to predominantly comorbid cardiovascular problems. Fragmentation in the health-care system and the current single disease model only exacerbate the problem of effectively helping people experiencing comorbidities and especially comorbidities involving both mental and physical conditions. New ways of thinking are required to redesign healthcare systems for the development of effective early intervention and screening to treat coexisting conditions and enable clinicians to deliver more integrated person-centred care to improve health outcomes and quality of life for this population.
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References
Bagdy G, Juhasz G. Biomarkers for personalised treatment in psychiatric diseases. Expert Opinion; Informa Healthcare. Med Dian. 2013;7(5):417–422.
Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiolgy of multimorbidity and implications for healthcare, research, and medical education: a cross sectional study. Lancet. 2012;380(9836):37–43. doi:10.1016/S0140-6736(12)60240-2.
Citrome LL, et al. Risk of treatment/emergent diabetes mellitus in patients receiving antipsychotics. Ann Pharmacother. 2007;41:1593–603.
Cloninger CR, Salloum IM, Mezzich JE. The dynamic origins of positive health and wellbeing. Int J Person Centered Med. 2012;2(2):179–87.
Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, et al. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet. 2011;378(9785):31–40.
Deakin B. et al. The physical health challenges in patients with severe mental illness: cardiovascular and metabolic risks. J Psychopharmacol. 2010;24(8).
De Hert M, et al. Physical Illness in patients with severe mental disorders II: Barriers to care, monitoring and treatment guidelines, plus recommendations at the system and individual level. World Psychiatry. 2011;10:52–77.
Feinstein A. The pre-therapeutic classification of co-morbidity in chronic disease. J Chronic Dis. 1970;23:455–68.
Fenton WS, Stover ES. Mood disorders: cardiovascular and diabetes comorbidity. Curr Opin Psychiatry. 2006;19(no4):421–7.
Flint J, Munafo M. Schizophrenia: genesis of a complex disease. Nature. 2014;511:412–3.
Goldberg D. The need for a special classification of mental disorders for general medical practice; towards ICD 11—primary care. Eur Psychiatry. 2011;26:53–6.
Gregoor JG, van der Weide J, Mulder W, et al. Polymorphism of the LEP- and LEPR gene and obesity in patients using antipsychotic medication. J Clin Psychopharmacol. 2009;26:21–5.
Grumbach K. Chronic illness, co-morbidities and the need for medical generalism. Ann Family Med. 2003;1:4–7.
Harrison C, et al. Examining different measures of multimorbidity, using a large prospective cross-sectional study in Australian genral practice. BMJ Open. 2014;4:e004694. doi:10.1136/bmjopen-2013-004694.
Heald AL, Montejo A, Millar HL, Hert M, McCrae J, Correll C. Physical health in patients with schizophrenia: current knowledge and practical recommendations. Management of physical health in patients with schizophrenia: practical recommendations. J Eur Psychiatric Assoc. 2010;25(2):S1–S46.
Hutter N, Schnurr A, Baumeister H. Healthcare costs in patients with diabetes and comorbid mental disorders—a systematic review. Diabetiologia. 2010;53(12):2470–9.
Katon WJ, et al. Multi-conditional collaborative care for chronic illnesses and depression. New Engl J. 2010;363:2611–20.
Mezzich JE, Salloum IM, Cloninger CR, Salvador-Carulla L, Kirmayer LJ, Banzato CEM, Wallcraft J, Botbol M. Person-centred integrative diagnosis: conceptual bases and structural model. Can J Psychiatry (Revue Canadienne de Psychiatrie). 2010;55(11):701–8.
Mezzich JE, Salloum IM. Comorbidity, positive health, and integration of services. In: Salloum IM, Mezzich JE, editors. Psychiatric diagnosis: challenges and prospects. Oxford, UK: Wiley-Blackwell; 2009.
Millar HL. The burden of multimorbidity: physical health in the severely mentally ill population. Die Psychiatrie. 2012.
Millar HL, Cimino L, van der Merwe AS. The dialogue on diabetes and depression African Nursing Training Programme: a collaborative training initiative to improve the recognition and management of diabetes and depression in Sub-Saharan Africa. In: Sartorius N, Maj M, Holt R, editors. Management of Comorbidity of Mental and Physical IIlness. Key Issues Mental Health. Basel, Karger 2015, 179, pp 148–156.
Moussavi S, Chatterji S, Verdes E, Tandon A, Patel V, Ustun B. Depression, chronic diseases and decrements in health: results from the World Health Surveys. Lancet. 2007;370(9590):851–8.
Naylor C, Parsonage M, McDaid D, Knapp M, Fossey M, Galea A. Long-term conditions and mental health: the cost of co-morbidities. The King’s Fund for Mental Health 2012.
Newcomer JW. Second-generation (atypical) antipsychotics and metabolic effects. A comprehensive literature review. CNS Drugs. 2005;19:1–93.
Ngo VK, Rubenstein A, Ganju V, Kanellis P, Loza N, Rabadan C, Daar AS. Grand challenges: integrating mental health care into the non-communicable disease agenda. PLOS Med. 2013;10(5):e 1001443. doi:10.1371/journal.pmed.1001443.
Papakostas GI. The efficacy, tolerability and safety of contemporary antidepressants. J Clin Psychiatry. 2010;71:e03.
Patel V, et al. Effectiveness of an intervention led by lay health counsellors for depression and anxiety disorders in primary care in Goa, India (MANAS): a cluster randomised controlled trial. Lancet. 2010;376(9758):2088–95.
Prince M, Patel V, Shekhar S, Maj M, Maselko J, Philips MR, Rahman A, Maselko J. No heath without mental health. Lancet. 2007;370(9590):859–877. doi:10.1016/S0140-6736(07)61238-0.
Salisbury C. Multimorbidity: redesigning healthcare for people who use it. Lancet. 2012;. doi:10.1016/S0140-6736(12)60482-6.
Salloum IM, Mezzich JE, Cordoba SE. Conceptual and methodological considerations in comorbidity. In: Salloum IM, Mezzich JE, editors. Psychiatric diagnosis: challenges and prospects. Oxford, UK: Wiley-Blackwell; 2009.
Salloum IM, Abou-Saleh MT, Krasnov V. Comorbidity, psychiatric diagnosis and the person-centered integrative diagnostic model. Int J Person Centered Med. 2012;2(2):168–72.
Salloum IM, Mezzich JE. Outlining the bases of person-centred integrative diagnosis. J Eval Clin Practice. 2011;17(2):354–6.
Salloum IM, Mezzich JE. Person-centered diagnosis. Int J Integr Care. 2010;10(Suppl):e027.
Starfield B. Thread and yarns: weaving the tapestry of co-morbidity. Ann Family Med. 2006;4:101–3.
Taylor A, Price K, Gill T, et al. Multimorbidity—not just an older person’s issues: results from an Australian biomedical study. BMC Public Health. 2010;10:718.
Wang PS, et al. Dopamine antagonism and the development of breast cancer. Arch Gen Psychiatry. 2002;59:1147–54.
World Health Action Plan 2013–2020: Global Action Plan for the Prevention and Control of NCDs 2013-202.
World Health Organisation and Calouste Gulbenkian Foundation. Integrating the response to mental disorders and other chronic diseases in health care systems. Geneva: World Health Organisation; 2014.
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Millar, H.L., Salloum, I.M. (2016). Psychiatric and General Medical Comorbidity. In: Mezzich, J., Botbol, M., Christodoulou, G., Cloninger, C., Salloum, I. (eds) Person Centered Psychiatry. Springer, Cham. https://doi.org/10.1007/978-3-319-39724-5_33
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