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IL-27 in Health and Disease

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Interleukin-27: Biological Properties and Clinical Application

Part of the book series: SpringerBriefs in Immunology ((BRIEFSIMMUN))

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Abstract

Interleukin-27 plays an important role in the regulation of immune response. IL-27 activates multiple signaling cascades, including the JAK-STAT, Akt/mTOR, ERK, and p38 MAPK pathways. Multiple studies have revealed that IL-27 regulates Th1, Th2, Th17, Treg, Tr1, Tfh T cell population, as well as B cells, DCs, and macrophages. Due to its broad inhibitory effects, IL-27 is pivotal in maintenance of fetomaternal tolerance and prevention of autoimmunity. However, the same broad inhibitory capabilities seem to compromise immune response to bacterial pathogens. Here, we have discussed the role of IL-27 in bacterial, viral, and parasitic infections, chronic inflammation in asthma, COPD, psoriasis and inflammatory bowel disease and autoimmune disorders, such as systemic lupus erythematosus, rheumatoid arthritis, Sjogren’s syndrome, autoimmune uveitis, multiple sclerosis, and autoimmune thrombocytopenia. IL-27 represents also a novel, promising target/agent for the treatment of cancer; however, protumor activities have also been reported.

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  1. Chair of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland

    Marek Jankowski

  2. Department of Gene Therapy, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland

    Tomasz Wandtke

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Jankowski, M., Wandtke, T. (2016). IL-27 in Health and Disease. In: Interleukin-27: Biological Properties and Clinical Application. SpringerBriefs in Immunology. Springer, Cham. https://doi.org/10.1007/978-3-319-39664-4_3

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