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Antimicrobial Drug Efflux Systems as Components of Bacterial Stress Responses

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Efflux-Mediated Antimicrobial Resistance in Bacteria

Abstract

Chromosomally-encoded broadly specific so-called multidrug efflux systems are widely distributed in bacteria where they are increasingly appreciated as important determinants of antimicrobial resistance. Nonetheless, it is evident that antimicrobial efflux is not the intended function for these efflux systems, many of which are specifically recruited in response to various cell-perturbing environmental stresses. As such, they likely function as components of protective stress responses in these bacteria. The prospect of non-antimicrobial stresses driving efflux gene expression and efflux-mediated antimicrobial resistance has important implications for resistance development in bacteria. A better understanding of the details of their stress regulation and their specific roles in bacterial stress responses may inform efforts to target them therapeutically.

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Acknowledgments

Research in the Poole laboratory on efflux and stress response determinants of antimicrobial resistance is supported by operating grants from Cystic Fibrosis Canada and the Canadian Institutes of Health Research.

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  1. Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada

    Keith Poole & Michael Fruci

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Correspondence to Keith Poole .

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  1. Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada

    Xian-Zhi Li

  2. U.S. Food and Drug Administration, Laurel, Maryland, USA

    Christopher A. Elkins

  3. University of Oklahoma, Norman, Oklahoma, USA

    Helen I. Zgurskaya

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Poole, K., Fruci, M. (2016). Antimicrobial Drug Efflux Systems as Components of Bacterial Stress Responses. In: Li, XZ., Elkins, C., Zgurskaya, H. (eds) Efflux-Mediated Antimicrobial Resistance in Bacteria. Adis, Cham. https://doi.org/10.1007/978-3-319-39658-3_26

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