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Ablation of Atrial Fibrillation in Women

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Abstract

Atrial fibrillation (AF) is the most common arrhythmia in elderly persons. Women have a slightly lower prevalence of AF compared to men. However, if women do have AF, they have a significant higher stroke risk and a higher mortality. Thromboembolic events can be effectively reduced with oral anticoagulation without more complications compared to men. Women seem to tolerate antiarrhythmic medication for rhythm control worse than men leading to more adverse side effects and more hospitalizations. AF also leads to a significant reduced quality of life, which is worse in women than in men. Despite the fact that women have nearly the same prevalence of AF as men, only 21 % of patients undergoing AF ablation are women, and when they present for AF ablation, they are older and have more cardiovascular comorbidities and more nonparoxysmal AF leading to a reduced AF-free survival. However, complication rate after AF ablation does not seem to be increased in women. In conclusion women should be referred for AF ablation more often and at an earlier stage to increase ablation success and to reduce time on antiarrhythmic medication.

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References

  1. Baman TS, Jongnarangsin K, Chugh A, Suwanagool A, Guiot A, Madenci A, Walsh S, Ilg KJ, Gupta SK, Latchamsetty R, Bagwe S, Myles JD, Crawford T, Good E, Bogun F, Pelosi Jr F, Morady F, Oral H. Prevalence and predictors of complications of radiofrequency catheter ablation for atrial fibrillation. J Cardiovasc Electrophysiol. 2011;22(6):626–31. doi:10.1111/j.1540-8167.2010.01995.x.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Bhave PD, Lu X, Girotra S, Kamel H, Vaughan Sarrazin MS. Race- and gender-related differences in care for patients newly diagnosed with atrial fibrillation. Heart Rhythm. 2015. doi:10.1016/j.hrthm.2015.03.031.

    PubMed  PubMed Central  Google Scholar 

  3. Calkins H, Kuck KH, Cappato R, Brugada J, Camm a J, Chen S-A, Crijns HJ, Damiano Jr RJ, Davies DW, DiMarco J, Edgerton J, Ellenbogen K, Ezekowitz MD, Haines DE, Haissaguerre M, Hindricks G, Iesaka Y, Jackman W, Jalife J, Jais P, Kalman J, Keane D, Kim YH, Kirchhof P, Klein G, Kottkamp H, Kumagai K, Lindsay BD, Mansour M, Marchlinski FE, McCarthy PM, Mont JL, Morady F, Nademanee K, Nakagawa H, Natale A, Nattel S, Packer DL, Pappone C, Prystowsky E, Raviele A, Reddy V, Ruskin JN, Shemin RJ, Tsao HM, Wilber D. 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design: a re. Heart Rhythm. 2012;9(4):632–96. doi:10.1016/j.hrthm.2011.12.016.

    Article  PubMed  Google Scholar 

  4. Camm AJ, Kirchhof P, Lip GYH, Schotten U, Savelieva I, Ernst S, Van Gelder IC, Al-Attar N, Hindricks G, Prendergast B, Heidbuchel H, Alfieri O, Angelini A, Atar D, Colonna P, De Caterina R, De Sutter J, Goette A, Gorenek B, Heldal M, Hohloser SH, Kolh P, Le Heuzey JY, Ponikowski P, Rutten FH. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Eur Heart J. 2010;31(19):2369–429. doi:10.1093/eurheartj/ehq278.

    Article  PubMed  Google Scholar 

  5. Dagres N, Nieuwlaat R, Vardas PE, Andresen D, Lévy S, Cobbe S, Kremastinos DT, Breithardt G, Cokkinos DV, Crijns HJGM. Gender-related differences in presentation, treatment, and outcome of patients with atrial fibrillation in Europe. A report from the Euro Heart Survey on Atrial Fibrillation. J Am Coll Cardiol. 2007;49(5):572–7. doi:10.1016/j.jacc.2006.10.047.

    Article  PubMed  Google Scholar 

  6. Deshmukh A, Patel NJ, Pant S, Shah N, Chothani A, Mehta K, Grover P, Singh V, Vallurupalli S, Savani GT, Badheka A, Tuliani T, Dabhadkar K, Dibu G, Reddy YM, Sewani A, Kowalski M, Mitrani R, Paydak H, Viles-Gonzalez JF. In-hospital complications associated with catheter ablation of atrial fibrillation in the United States between 2000 and 2010: Analysis of 93 801 procedures. Circulation. 2013;128(19):2104–12. doi:10.1161/CIRCULATIONAHA.113.003862.

    Article  PubMed  Google Scholar 

  7. Fang MC, Singer DE, Chang Y, Hylek EM, Henault LE, Jensvold NG, Go AS. Gender differences in the risk of ischemic stroke and peripheral embolism in atrial fibrillation: the AnTicoagulation and Risk factors in Atrial fibrillation (ATRIA) study. Circulation. 2005. doi:10.1161/CIRCULATIONAHA.105.553438.

    PubMed Central  Google Scholar 

  8. Go AS, Hylek EM, Phillips KA, Chang Y, Henault LE, Selby JV, Singer DE. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA. 2001;285(18):2370–5. doi:jcc10004 [pii].

    Article  CAS  PubMed  Google Scholar 

  9. Granger CB, Alexander JH, McMurray JJV, Lopes RD, Hylek EM, Hanna M, Al-Khalidi HR, Ansell J, Atar D, Avezum A, Bahit MC, Diaz R, Easton JD, Ezekowitz JA, Flaker G, Garcia D, Geraldes M, Gersh BJ, Golitsyn S, Goto S, Hermosillo AG, Hohnloser SH, Horowitz J, Mohan P, Jansky P, Lewis BS, Lopez-Sendon JL, Pais P, Parkhomenko A, Verheugt FW, Zhu J, Wallentin L. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365(11):981–92. doi:10.1056/NEJMoa1107039.

    Article  CAS  PubMed  Google Scholar 

  10. Hoyt H, Bhonsale A, Chilukuri K, Alhumaid F, Needleman M, Edwards D, Govil A, Nazarian S, Cheng A, Henrikson CA, Sinha S, Marine JE, Berger R, Calkins H, Spragg DD. Complications arising from catheter ablation of atrial fibrillation: temporal trends and predictors. Heart Rhythm. 2011;8(12):1869–74. doi:10.1016/j.hrthm.2011.07.025.

    Article  PubMed  Google Scholar 

  11. Humphries KH, Kerr CR, Connolly SJ, Klein G, Boone JA, Green M, Sheldon R, Talajic M, Dorian P, Newman D. New-onset atrial fibrillation Sex differences in presentation, treatment, and outcome. Circulation. 2001;103:2365–70.

    Article  CAS  PubMed  Google Scholar 

  12. Jais P, Cauchemez B, Macle L, Daoud E, Khairy P, Subbiah R, Hocini M, Extramiana F, Sacher F, Bordachar P, Klein G, Weerasooriya R, Clémenty J, Haissaguerre M. Catheter ablation versus antiarrhythmic drugs for atrial fibrillation: the A4 study. Circulation. 2008;118(24):2498–505. doi:CIRCULATIONAHA.108.772582 [pii] 10.1161/CIRCULATIONAHA.108.772582.

  13. Rienstra M, Van Veldhuisen DJ, Hagens VE, Ranchor AV, Veeger NJGM, Crijns HJGM, Van Gelder IC. Gender-related differences in rhythm control treatment in persistent atrial fibrillation: data of the rate control versus electrical cardioversion (RACE) study. J Am Coll Cardiol. 2005;46(7):1298–306. doi:10.1016/j.jacc.2005.05.078.

    Article  PubMed  Google Scholar 

  14. Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener H-C, Joyner CD, Wallentin L, and the RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361(12):1139–51. doi:10.1056/NEJMoa1404595.

    Article  CAS  PubMed  Google Scholar 

  15. Takigawa M, Kuwahara T, Takahashi A, Watari Y, Okubo K, Takahashi Y, Takagi K, Kuroda S, Osaka Y, Kawaguchi N, Yamao K, Nakashima E, Sugiyama T, Akiyama D, Kamiishi T, Kimura S, Hikita H, Hirao K, Isobe M. Differences in catheter ablation of paroxysmal atrial fibrillation between males and females. Int J Cardiol. 2013;168(3):1984–91. doi:10.1016/j.ijcard.2012.12.101.

    Article  PubMed  Google Scholar 

  16. Vallakati A, Reddy M, Sharma A, Kanmanthareddy A, Sridhar A, Pillarisetti J, Atkins D, Konda B, Bommana S, Di Biase L, Santangeli P, Natale A, Lakkireddy D. Impact of gender on outcomes after atrial fibrillation ablation. Int J Cardiol. 2015;187:12–6. doi:10.1016/j.ijcard.2015.03.341.

    Article  PubMed  Google Scholar 

  17. Whitbeck MG, Charnigo RJ, Khairy P, Ziada K, Bailey AL, Zegarra MM, Shah J, Morales G, Macaulay T, Sorrell VL, Campbell CL, Gurley J, Anaya P, Nasr H, Bai R, Di Biase L, Booth DC, Jondeau G, Natale A, Roy D, Smyth S, Moliterno DJ, Elayi CS. Increased mortality among patients taking digoxin – analysis from the AFFIRM study. Eur Heart J. 2013;34(20):1481–8. doi:10.1093/eurheartj/ehs348.

    Article  CAS  PubMed  Google Scholar 

  18. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke. 1991. doi:10.1161/01.STR.22.8.983.

    Google Scholar 

  19. Wyse DG, Waldo AL, DiMarco JP, Domanski MJ, Rosenberg Y, Schron EB, Kellen JC, Greene HL, Mickel MC, Dalquist JE, Corley SD. A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med. 2002;347(23):1825–33. doi:10.1056/NEJMoa021328 347/23/1825 [pii].

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Correspondence to Stephanie Fichtner .

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Fichtner, S. (2017). Ablation of Atrial Fibrillation in Women. In: Presbitero, P., Mehilli, J., Petronio, A. (eds) Percutaneous Treatment of Cardiovascular Diseases in Women. Springer, Cham. https://doi.org/10.1007/978-3-319-39611-8_14

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  • DOI: https://doi.org/10.1007/978-3-319-39611-8_14

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