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Food Safety pp 89–111Cite as

Heterocyclic Amines

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Abstract

Heterocyclic amines are the potential mutagens and carcinogens that are generally responsible for inducing several types of cancers and DNA damage after accumulation in the body. Formation of these carcinogenic compounds is linked with the meat products that are subjected to higher temperature during processing for longer periods of time. Detection and quantification of these compounds is a big challenge for the scientists. With the advancement in the technology, several reliable and comprehensive techniques have been developed to detect the presence of these mutagens. However, still there is a need to introduce some rapid and more precise techniques that can determine the actual concentrations and types of heterocyclic amines in the food samples. Additionally, more studies should be conducted to evaluate the potential of several antioxidant compounds that can control the quantity of heterocyclic amines without adversely affecting the organoleptic attributes of food products.

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References

  • Ahn J, Grun IU (2006) Heterocyclic amines: 2. Inhibitory effects of natural extracts on the formation of polar and non-polar heterocyclic amines in cooked beef. J Food Sci 70:263–268

    Article  Google Scholar 

  • Alaejos MS, Gonzalez V, Afonso AM (2007) Exposure to heterocyclic aromatic amines from the consumption of cooked red meat and its effect on human cancer risk: a review. Food Addit Contam Part A 45:2–24

    Google Scholar 

  • Anderson KE, Sinha R, Kulldorff M, Gross M, Lang NP, Barber C et al (2002) Meat intake and cooking techniques: associations with pancreatic cancer. Mutat Res 506–507:225–231

    Article  Google Scholar 

  • AOAC (1995) Histamine in seafood: Biological method. Sec. 35.1.30, Method 954.04. In Cunniff PA (ed) Official methods of analysis of AOAC International, 16th ed, p 14–15. AOAC International, Gaithersburg, MD

    Google Scholar 

  • Archer CL, Morse P, Jones RF, Shirai T, Haas GP, Wang CY (2000) Carcinogenicity of the n-hydroxy derivative of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine, 2-amino-3,8-dimethyl-imidazo [4,5-f] quinoxaline and 3,2-dimethyl-4-aminobiphenyl in the rat. Cancer Lett 155:55–60

    Article  CAS  Google Scholar 

  • Augustsson K, Lindblad J, Overik E, Steineck G (1999) A population-based dietary inventory of cooked meat and assessment of the daily intake of food mutagens. Food Addit Contam 16:215–225

    Article  CAS  Google Scholar 

  • Balogh Z, Gray JI, Gomaa E, Booren AM (2000) Formation and inhibition of heterocyclic aromatic amines in fried ground beef patties. Food Chem Toxicol 38:395–401

    Article  CAS  Google Scholar 

  • Britt C, Gomaa EA, Gray JI, Booren AM (1998) Influence of cherry tissue on lipid oxidation and heterocyclic aromatic amine formation in ground beef patties. J Agric Food Chem 46:4891–4897

    Article  CAS  Google Scholar 

  • Butler LM, Sinha R, Millikan RC, Martin CF, Newman B, Gammon MD, Ammerman AS, Sandler RS (2003) Heterocyclic amines, meat intake, and association with colon cancer in a population-based study. Am J Epidemiol 157:5

    Article  Google Scholar 

  • Calabrese EJ (1996) Biochemical individuality: the next generation. Regul Toxicol Pharmacol 24:58–67

    Article  Google Scholar 

  • Case RAM, Hosker ME, McDonald DB, Pearson JT (1954) Tumors of the urinary bladder in workmen engaged in the manufacture and use of certain dyestuff intermediates in the British chemical industry. Br J Ind Med 11:75–104

    CAS  Google Scholar 

  • Cross AJ, Sinha R (2004) Meat-related mutagens/carcinogens in the etiology of colorectal cancer. Environ Mol Mutagen 44:44–55

    Article  CAS  Google Scholar 

  • Duflos G, Dervin C, Malle P, Bouquelet S (1999) Relevance of matrix effect in determination of biogenic amines in plaice (Pleuronectes platessa) Whiting (Merlangus merlangus). J AOAC Int 82:1097–1101

    CAS  Google Scholar 

  • Edenharder R, Leopold C, Kries M (1995) Modifying actions of solvent extracts from fruit and vegetable residues on 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoxaline (MeIQx) induced mutagenesis in Salmonella typhimurium TA 98. Mutat Res 341:303–318

    Article  CAS  Google Scholar 

  • Edenharder R, Sager JW, Glatt H, Muckel E, Platt KL (2002) Protection by beverages, fruits, vegetables, herbs, and flavonoids against genotoxicity of 2- acetylaminofluorene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in metabolically competent V79 cells. Mutat Res 521:57–72

    Article  CAS  Google Scholar 

  • Faulkner J (1994) Mechanism of heterocyclic amine formation in fried ground beefthe role of oxidized lipid and the Maillard reaction. PhD dissertation. East Lansing, MI: Michigan State University.

    Google Scholar 

  • Felton JS, Fultz E, Dolbeare FA, Knize MG (2000) Reduction of heterocyclic aromatic amine mutagens/carcinogens in fried beef patties by microwave pretreatment. Biology and Biotechnology Research Program, L-452, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA

    Google Scholar 

  • Frandsen H, Frederiksen H, Alexander J (2002) 2-Amino-1-methyl-6-(5hydroxy)-phenylimidazo[4,5-b]pyridine (5-OH-PhIP), a biomarker for the genotoxic dose of the heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Food Chem Toxicol 40(8):1125–1130

    Article  CAS  Google Scholar 

  • Garner RC, Lightfoot TJ, Cupid BC, Russell D, Coxhead JM, Kutschera W, Priller A, Rom W, Steier P, Alexander DJ, Leveson SH, Dingley KH, Mauthe RJ, Turteltaub KW (1999) Comparative biotransformation studies of MeIQx and PhIP in animal models and humans. Cancer Lett 143:161–165

    Article  CAS  Google Scholar 

  • Hala A (2011) The effect of green tea and olive oil on the mutagenic activity of heterocyclic amines extracted from common food consumed in Saudi Arabia. Int J Food Sci Nutr 62:295–302

    Article  Google Scholar 

  • Hala A, Heba S (2010) The effect of rosemary on the mutagenic activity of heterocyclic amines extracted from common food consumed in Saudi Arabia. Int J Food Sci Nutr 61:192–203

    Article  Google Scholar 

  • Hungerford JM, Walker KD, Wekell MM, LaRose JE, Throm HR (1990) Selective determination of histamine by flow injection analysis. Anal Chem 62(18):1971–1976

    Article  CAS  Google Scholar 

  • Hungerford JM, Hollingworth TA, Wekell MM (2001) Automated kinetics-enhanced flowinjection method for histamine in regulatory laboratories: rapid screening and suitability requirements. Anal Chim Acta 438:123–129

    Article  CAS  Google Scholar 

  • Ito N, Hasegawa R, Sano M, Tarnano S, Esumi H, Takayarna S et al (1991) A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine- (PhIP). Carcinogenesis 12:1503–1506

    Article  CAS  Google Scholar 

  • Jagerstad M, Skog K (2005) Genotoxicity of heat-processed foods. Mutat Res 574:156–172

    Article  Google Scholar 

  • Jagerstad M, Skog K, Arvidsson P, Solyakov A (1998) Chemistry, formation and occurrence of genotoxic heterocyclic amines identified in model systems and cooked foods. Zeitschrift fuer Lebensmittel-Untersuchung und-Forschung A 207:419–427

    Article  Google Scholar 

  • John EM, Stern MC, Sinha R, Koo JK (2011) Meat consumption, cooking practices, meat mutagens, and risk of prostate cancer. Nutr Cancer 63:525–537

    Article  Google Scholar 

  • Kato T, Harashima T, Moriya N, Kikugawa K, Hiramoto K (1996) Formation of the mutagenic/carcinogenic imidazoquinoxaline-type heterocyclic amines through the unstable free radical Maillard intermediates and its inhibition by phenolic antioxidants. Carcinogenesis 17:2469

    Article  CAS  Google Scholar 

  • Keating GA (2001) US dietary exposures to heterocyclic amines. J Expo Anal Environ Epidemiol 11:155–168

    Article  Google Scholar 

  • Keating GA, Sinha R, Layton D, Salmon CP, Knize MG, Bogen KT et al (2000) Comparison of heterocyclic amine levels in home-cooked meats with exposure indicators (United States). Cancer Causes Control 11:731–739

    Article  CAS  Google Scholar 

  • Kidd L, Stillwell W, Yu M, Wishnock J, Skipper P, Ross R, Henderson B, Tannenbaum R (1999) Urinary excretion of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in white, African–American, and Asian–American men in Los Angeles county. Cancer Epidemiol Biomarkers Prev 8:439–445

    CAS  Google Scholar 

  • Knize MG, Felton JS (2005) Formation and human risk of carcinogenic heterocyclic amines formed from natural precursors in meat. Nutr Rev 63:158–165

    Article  Google Scholar 

  • Knize MG, Dolbeare FA, Carroll KL, Moore DH, Felton JS (1994) Effect of cooking time and temperature on the heterocyclic amine content of fried beef patties. Food Chem Toxicol 32:595–603

    Article  CAS  Google Scholar 

  • Knize MG, Kulp KS, Salmon CP, Keating GA, Felton JS (2002) Factors affecting human heterocyclic amine intake and the metabolism of PhIP. Mutat Res 506–507:153–162

    Article  Google Scholar 

  • Kulp KS, Knize MG, Malfatti MA, Salmon CP, Felton JS (2000) Identification of urine metabolites of 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine following consumption of a single cooked chicken meal in humans. Carcinogenesis 21:2065–2072

    Article  CAS  Google Scholar 

  • Lagergren J, Bergstrom R, Lindgren A, Nyren O (2000) The role of tobacco, snuff and alcohol use in the aetiology of cancer of the oesophagus and gastric cardia. Int J Cancer 85:340–346

    Article  CAS  Google Scholar 

  • Lang NP, Butler MA, Massengill JP, Lawson M, Stotts RC, Hauer-Jensen M, Kadlubar FF (1994) Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps. Cancer Epidemiol Biomarkers Prev 3:675–682

    CAS  Google Scholar 

  • Lang NP, Nowell S, Malfatti MA, Kulp KS, Knize MG, Davis C, Massengill J, Williams S, MacLeod S, Dingley KH, Felton JS, Turteltaub KW (1999) In vivo human metabolism of [2-14C]2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP). Cancer Lett 143:135–138

    Article  CAS  Google Scholar 

  • Letterman RD, Amirtharajah A, O’Melia CR (1999) Coagulation and flocculation. In Letterman RD (technical editor) Water quality and treatment, 5th ed. American Water Works Association, McGraw-Hill, New York

    Google Scholar 

  • Lim W, Khoon LC, Eng P, Leong SS, Lim E, Lim TK et al (2011) Meat consumption and risk of lung cancer among never-smoking women. Nutr Cancer 63:850–859

    Article  Google Scholar 

  • Lopez-Sabater EI, Rodriguez-Jerez JJ, Hernandez-Herrero M, Roig-Sagues AX, Mora-Ventura MT (1996) Sensory quality and histamine forming during controlled decomposition of tuna (Thunnus thynnus). J Food Prot 59:167–174

    CAS  Google Scholar 

  • Lynch AM, Knize MG, Boobis AR, Gooderham NJ, Davies DS, Murray S (1992) Intra and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[ 4,5-f]quinoxaline and 2-amino-1-methyl-6-phenylimidazo[ 4,5-b]pyridine, carcinogens present in cooked beef. Cancer Res 52:6216–6223

    CAS  Google Scholar 

  • Malfatti MA, Kulp KS, Knize MG, Davis C, Massengill JP, Williams S, Nowell S, MacLeod S, Dingley KH, Turteltaub KW, Lang NP, Felton JS (1999) The identification of [2-(14)C]2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine metabolites in humans. Carcinogenesis 20:705–713

    Article  CAS  Google Scholar 

  • Monika G (2007) Effect of oil marinades with garlic, onion, and lemon juice on the formation of heterocyclic aromatic amines in fried beef patties. J Agric Food Chem 55:10240–10247

    Article  Google Scholar 

  • Monti SM, Ambrosino P, Skog K, Fogliano V (2001) Characterization of phenolic compounds in virgin olive oil and their effect on the formation of carcinogenic/mutagenic heterocyclic amines in a model system. J Agric Food Chem 49:3969–3975

    Article  CAS  Google Scholar 

  • Murray S, Lynch AM, Knize MG, Gooderham NJ (1993) Quantification of the carcinogens 2-amino-3,8-dimethylimidazo [4,5-f]quinoxaline, 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in food using a combined assay based on capillary column gas chromatography negative ion mass spectrometry. J Chromatogr B Biomed Sci Appl 616:211–219

    Article  CAS  Google Scholar 

  • Nerurkar PV, Le Marchand L, Cooney RV (1999) Effects of marinating with Asian marinades or Western barbecue sauce on PhIP and MeIQx formation in barbecued beef. Nutr Cancer 34:147–152

    Article  CAS  Google Scholar 

  • Nobuyuki I, Hasegawa R, Imaidi K, Tamano S, Hagiwara A, Hirose M et al (1997) Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) in the rat. Mutat Res 376:107–114

    Article  Google Scholar 

  • Oguri A, Suda M, Totsuka Y, Sugimura T, Wakabayashi K (1998) Inhibitory effects of antioxidants on formation of heterocyclic amines. Mutat Res 402:237–245

    Article  CAS  Google Scholar 

  • Onal A (2007) A review: Current analytical methods for the determination of biogenic amines in foods. Food Chem 103:1475–1486

    Article  Google Scholar 

  • Oreglia F, De Stefani E, Boffetta P, Brennan P, Deneo Pellegrini H (2001) Meat, fat and risk of laryngeal cancer: a case-control study in Uruguay. Oral Oncol 37:141–145

    Article  Google Scholar 

  • Oz F, Kaya M (2011) The inhibitory effect of red pepper on heterocyclic aromatic amines in fried beef Longissimus dorsi muscle. J Food Process Preserv 35:806–812

    Article  CAS  Google Scholar 

  • Patange SB, Mukundan MK, Kumar AK (2005) A simple and rapid method for colorimetric determination of histamine in fish flesh. Food Control 16:465–472

    Article  CAS  Google Scholar 

  • Persson E, Sjoholm I, Skog K (2003) Effect of high water holding capacity on the formation of heterocyclic amines in fried beef burgers. J Agric Food Chem 51:4472–4477

    Article  CAS  Google Scholar 

  • Probst-Hensch NM, Sinha R, Longnecker MP, Witte JS, Ingles SA, Frankl HD, Lee ER, Haile RW (1997) Meat preparation and colorectal adenomas in a large sigmoidoscopy-based case-control study in California (US). Cancer Causes Control 8:175–183

    Article  CAS  Google Scholar 

  • Puangsombat K, Jirapakkul W, Smith JS (2011) Inhibitory activity of Asian spices on heterocyclic amines formation in cooked beef patties. J Food Sci 76:174–180

    Article  Google Scholar 

  • Rahman UU, Sahar A, Khan MI, Nadeem M (2014) Production of heterocyclic aromatic amines in meat: chemistry, health risks and inhibition. A review. LWT Food Sci Technol 59:229–233

    Article  CAS  Google Scholar 

  • Rauscher R, Edenharder R, Platt KL (1998) In vitro antimutagenic and in vivo anticlastogenic effects of carotenoids and solvent extracts from fruits and vegetables rich in carotenoids. Mutat Res 413:129–142

    Article  CAS  Google Scholar 

  • Reistad R, Nyholm S, Haug L, Becher G, Alexander J (1999) 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human hair as a biomarker for dietary exposure. Biomarkers 4:263–271

    Article  CAS  Google Scholar 

  • Rohrmann S, Hermann S, Linseisen J (2009) Heterocyclic aromatic amine intake increases colorectal adenoma risk: finding from a prospective European cohort study. Am J Clin Nutr 89:1418–1424

    Article  CAS  Google Scholar 

  • Sachse C, Bhambra U, Smith G, Lightfoot TJ, Barrett JH, Scollay J, Garner RC, Boobis AR, Wolf CR, Gooderham NJ (2003) Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism. Br J Clin Pharmacol 55:68–76

    Article  CAS  Google Scholar 

  • Sahar A, Portanguen S, Kondjoyan A, Dufour E (2010) Potential of synchronous fluorescence spectroscopy coupled with chemometrics to determine the heterocyclic aromatic amines in grilled meat. Eur Food Res Technol 231:803–812

    Article  CAS  Google Scholar 

  • Shin IS, Rodgers WJ, Gomaa EA, Strasburg GM, Gray JI (2002) Inhibition of heterocyclic aromatic amine formation in fried ground beef patties by garlic and selected garlic-related sulfur compounds. J Food Prot 65:1766–1770

    CAS  Google Scholar 

  • Shon MY, Choi SD, Kahng GG, Nam SH, Sung NJ (2004) Antimutagenic, antioxidant and free radical scavenging activity of ethyl acetate extracts from white, yellow and red onions. Food Chem Toxicol 42:659–666

    Article  CAS  Google Scholar 

  • Shun JT, Shinn NJ, Lee H (1996) Naturally occurring diallyl disulfide inhibits the formation of carcinogenic heterocyclic aromatic amines in boiled pork juice. Mutagenesis 11:235–240

    Article  Google Scholar 

  • Singer PC, Reckhow DA (1999) Chemical oxidation. In Letterman RD (technical editor) Water quality and treatment, 5th ed. American Water Works Association, McGraw-Hill, New York

    Google Scholar 

  • Sinha R, Chow WH, Kulldorff M, Denobile J, Butler J, Garcia M, Weil R, Hoover RN, Rothman N (1999a) Well-done, grilled red meat increases the risk of colorectal adenomas. Cancer Res 59:4320–4324

    CAS  Google Scholar 

  • Sinha R, Kulldorff M, Curtin J, Brown CC, Alavanja MC, Swanson CA (1999b) Fried, well-done red meat and risk of lung cancer in women (United States). Cancer Causes Control 9:621–630

    Article  Google Scholar 

  • Skog KI, Johansson MA, Jagerstad MI (1998) Carcinogenic heterocyclic amines in model systems and cooked foods: a review on formation, occurrence and intake. Food Chem Toxicol 36:879–896

    Article  CAS  Google Scholar 

  • Smith JS, Ameri F, Gadgil P (2008) Effect of marinades on the formation of heterocyclic amines in grilled beef steaks. J Food Sci 73:100–105

    Article  Google Scholar 

  • Stavric B, Matula TI, Klassen R, Downie RH (1996) The effect of teas on the in vitro mutagenic potential of heterocyclic aromatic amines. Food Chem Toxicol 34:515–523

    Article  CAS  Google Scholar 

  • Stillwell WG, Kidd LCR, Wishnok JS, Tannenbaum SR, Sinha R (1997) Urinary excretion o unmetabolized and Phase II conjugates of 2-amino-1-methyl 6-phenylimidazo[4,5-b] pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in humans: relationship to cytochrome P4501A2 and N-acetyltransferase activity. Cancer Res 57:3457–3464

    CAS  Google Scholar 

  • Sugimura T (1986) Past, present and future of mutagens in cooked foods. Environ Health Perspect 67:5–10

    Article  CAS  Google Scholar 

  • Sugimura T (1997) Overview of carcinogenic heterocyclic amines. Mutat Res 376:211–219

    Article  CAS  Google Scholar 

  • Sugimura T, Wakabayashi K, Nakagama H, Nagao M (2004) Heterocyclic amines: mutagens/carcinogens produced during cooking of meat and fish. Cancer Sci 95:290–299

    Article  CAS  Google Scholar 

  • Taylor SL, Lieber ER, Leatherwood MA (1978) A simplified method for histamine analysis of foods. J Food Sci 43:247–250

    Article  CAS  Google Scholar 

  • Taylor RT, Fultz E, Knize M (1986) Mutagen formation in a model beef supernatant fraction: elucidation of the role of water in fried ground beef mutagenicity. Environ Mol Mutagen 8:84–85

    Google Scholar 

  • Toribio F, Moyano E, Puignou L, Galceran MT (2002) Ion-trap tandem mass spectrometry for the determination of heterocyclic amines in food. J Chromatogr 948:267–281

    Article  CAS  Google Scholar 

  • Turner PC, Dingley KH, Coxhead J, Russell S, Garner CR (1998) Detectable levels of serum aflatoxin B1-albumin adducts in the United Kingdom population: implications for aflatoxin-B1 exposure in the United Kingdom. Cancer Epidemiol Biomarkers Prev 7:441–447

    CAS  Google Scholar 

  • United States Department of Health and Human Services Public Health Service (2011) National Toxicology Program. Report on Carcinogens

    Google Scholar 

  • Viegas O, Amaro LF, Ferreira IM, Pinho O (2012) Inhibitory effect of antioxidant-rich marinades on the formation of heterocyclic aromatic amines in pan-fried beef. J Agric Food Chem 60(24):6235–6240

    Article  CAS  Google Scholar 

  • Vineis P, Pirastu R (1997) Aromatic amines and cancer. Cancer Causes Control 8:346–355

    Article  CAS  Google Scholar 

  • Vitaglione P, Fogliano V (2004) Use of antioxidants to minimize the human health risk associated to mutagenic/carcinogenic heterocyclic amines in food. J Chromatogr B 802:189–199

    Article  CAS  Google Scholar 

  • Wang YY, Vuolo LL, Spingarn NE, Weisburger JH (1982) Formation of mutagens in cooked foods V. the mutagen reducing effect of soy protein concentrates and antioxidants during frying of beef. Cancer Lett 16:179–189

    Article  CAS  Google Scholar 

  • Ward E, Carpenter A, Markowitz S, Roberts D, Halperin W (1991) Excess number of bladder cancers in workers exposed to ortho-toluidine and aniline. JNCI 83:501–506

    Article  CAS  Google Scholar 

  • Weisburger JH (2002) Comments on the history and importance of aromatic and heterocyclic amines in public health. Mutat Res 506–507:9–20

    Article  Google Scholar 

  • Weisburger JH, Nagao M, Wakabayashi K, Oguri A (1994) Prevention of heterocyclic amine formation by tea and tea polyphenols. Cancer Lett 83:143–147

    Article  CAS  Google Scholar 

  • Wightman JD (2004) Red berries and their health benefits. In: Shahidi F, Weerasinghe DK (eds) Nutraceutical beverages—chemistry, nutrition, and health effects. American Chemical Society, Washington, DC, pp 123–132

    Google Scholar 

  • Yen GC, Chen HY (1995) Antioxidant activity of various tea extracts in relation to their anti-mutagenicity. J Agric Food Chem 43:27–32

    Article  CAS  Google Scholar 

  • Zheng W, Lee S (2009) Well-done meat intake, heterocyclic amine exposure and cancer risk. Nutr Cancer 61:437–446

    Article  CAS  Google Scholar 

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Sahar, A., ur Rahman, U., Khan, M.I., Khan, M.A. (2016). Heterocyclic Amines. In: Selamat, J., Iqbal, S. (eds) Food Safety. Springer, Cham. https://doi.org/10.1007/978-3-319-39253-0_5

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