Skip to main content
SpringerLink
Log in
Book cover

Pediatric Urogenital Radiology pp 465–480Cite as

Upper Urinary Tract Dilatation in Newborns and Infants and the Postnatal Work-Up of Congenital Uro-nephropathies

  • Chapter
  • First Online:

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

In many European countries, obstetric ultrasound (US) is performed routinely during normal pregnancies. This leads to the discovery of many fetal anomalies, and, among them, uro-nephropathies represent one of the largest groups amenable to neonatal management. They are now included in the so-called CAKUT [congenital anomalies of the kidney and urinary tract] group (Renkema et al. 2011; Wiesel et al 2005; Ek et al. 2007).

This is a preview of subscription content, log in via an institution.

References

  • Adeb M, Daye K, Dihlman JR et al (2013) MR urography in evaluation of duplicated renal collecting systems. MRI Clin N Amer 21:717–730

    Google Scholar 

  • Aslam M, Watson AR (2006) Unilateral MDK: long-term outcomes. Arch Dis Child 91:820–823

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Assael BM, Guez S, Marra E et al (1998) Congenital reflux nephropathy: a follow-up of 108 cases diagnosed perinatally. Br J Urol 82:252–257

    Article  CAS  PubMed  Google Scholar 

  • Atiyeh B, Husmann D, Baum M (1993) Contralateral renal abnormalities in patients with renal agenesis and non-cystic renal dysplasia. Pediatrics 91:812–815

    PubMed  CAS  Google Scholar 

  • Avni EF, Ayadi K, Rypens F et al (1997) Can careful ultrasound examination of the urinary tract exclude vesicoureteric reflux in the neonate. Br J Radiol 70:977–982

    Article  CAS  PubMed  Google Scholar 

  • Avni EF, Bali MA, Regnault M et al (2000) MR urography in children. Eur Radiol 43:154–166

    Article  Google Scholar 

  • Avni EF, Garel L, Cassart M et al (2006) Perinatal assessment of hereditary cystic renal diseases. Pediatr Radiol 36:405–416

    Article  PubMed  Google Scholar 

  • Avni FE, Garel C, Cassart M et al (2012) Imaging and classification of congenital cystic renal diseases. AJR Am J Roentgenol 198:1004–1013

    Article  PubMed  Google Scholar 

  • Barbosa JA, Chow J, Benson CB et al (2012) Postnatal longitudinal evaluation of children diagnosed with prenatal hydronephrosis. Prenat Diagn 32:1242–1249

    Article  PubMed  Google Scholar 

  • Baskin LS, Zderic SA, Snyder HM et al (1994) Primary dilated megaureter long-term follow-up. J Urol 152:618–621

    Article  CAS  PubMed  Google Scholar 

  • Blyth B, Passerini Glazel G, Camuffo C et al (1993) Endoscopic incision of ureteroceles intravesical versus ectopic. J Urol 149:556–560

    Article  CAS  PubMed  Google Scholar 

  • Bouachrine H, Lemelle JL, Didier F et al (1996) A follow-up study of pre-natally detected primary VUR: a review of 61 patients. Br J Urol 78:936–939

    Article  CAS  PubMed  Google Scholar 

  • Bouzada MCF, Oliveira FA, Pereira AK et al (2004) Diagnostic accuracy of postnatal pelvic diameter as a predictor of uropathy. Pediatr Radiol 34:798–804

    Article  PubMed  Google Scholar 

  • Burge DM, Griffiths MD, Malone PG et al (1992) Fetal VUR outcome following conservative management. J Urol 148:1743–1745

    Article  CAS  PubMed  Google Scholar 

  • Capolicchio G, Leonard MP, Wong C et al (1999) Prenatal diagnosis of hydronephrosis: impact on renal function. J Urol 162:1029–1032

    Article  CAS  PubMed  Google Scholar 

  • Chertin B, Fridman A, Knizhnik M et al (1999) Does early detection of UPJ obstruction improve surgical outcome? J Urol 162:1037–1040

    Article  CAS  PubMed  Google Scholar 

  • Darge K, Higgins M, Hway TJ et al (2013) MR and CT in pediatric urolody. Radiol Clin N Am 51:583–598

    Article  PubMed  Google Scholar 

  • Docimo SG, Silver RI (1997) Renal ultrasonography in newborns with prenatally detected hydronephrosis: why wait? J Urol 157:1387–1389

    Article  CAS  PubMed  Google Scholar 

  • Duckett JW (1993) When to operate on neonatal hydronephrosis. Urology 42:617–619

    Article  PubMed  Google Scholar 

  • Duong HP, Piepsz A, Collier F et al (2013) Predicting the clinical outcome of antenatally detected unilateral pelviureteric junction stenosis. Urology 82:691–696

    Article  PubMed  Google Scholar 

  • Ek S, Lindefeldt KJ, Vanicio L et al (2007) Fetal hydronephrosis: prevalence, natural history and postnatal consequences in an unselected population. Acta Obstet Gynecol 86:1463–1466

    Article  Google Scholar 

  • Eskild-Jensen A, Gordon I, Piepsz A et al (2004) Interpretation of the renogram : problems and pitfalls in hydronephrosis in children. BJU Int 94:887–892

    Article  PubMed  Google Scholar 

  • Flack CE, Bellinger MF (1993) The multicystic dysplastic kidney and contralateral vesicoureteral reflux protection of the solitary kidney. J Urol 150:1873–1874

    Article  CAS  PubMed  Google Scholar 

  • Gordon I, Colarinha P, Piepz A et al (2001) Guidelines for standard and diuretic renography in children. Eur J Nucl Med 28:BP21–BP30

    PubMed  CAS  Google Scholar 

  • Gordon I, Piepsz A, Sixt R (2011) Guidelines for standard and diuretic renogram in children. Eur J Nucl Med Mol Imaging 38:1175–1188

    Article  PubMed  Google Scholar 

  • Hagg MJ, Mourachov PV, Snyder HM et al (2000) The modern endoscopic approach to ureterocele. J Urol 163:940–943

    Article  CAS  PubMed  Google Scholar 

  • Herndon CDA, McKenna PH, Kolon TF et al (1999) A multicenter outcomes analysis of patients with neonatal reflux presenting with prenatal hydronephrosis. J Urol 162:1203–1208

    Article  CAS  PubMed  Google Scholar 

  • Hrair-Georges JM, Rushton HG, Bulas D (1993) Unilateral agenesis may result from in utero regression of MDK. J Urol 150:793–794

    Article  Google Scholar 

  • Hulbert WC, Rosenberg HK, Cartwright PC et al (1992) The predictive value of ultrasonography in evaluation of infants with posterior urethral valves. J Urol 148:122–124

    Article  CAS  PubMed  Google Scholar 

  • Husman D, Strand B, Ewalt D et al (1999) Management of ectopic ureterocele associated with renal duplication. J Urol 162:1406–1409

    Article  Google Scholar 

  • Ismaïli K, Avni FE, Wissing JK et al (2004) Long term outcome of infants with mild and moderate fetal pyelectasis: validation of neonatal US as a screening tool to detect significant nephro-uropathy. J Pediatr 144:759–765

    PubMed  Google Scholar 

  • Ismaïli K, Avni FE, Alexander M et al (2005) Routine VCUG is of no value in neonates with unilateral MDK. J Pediatr 146:759–763

    Article  PubMed  Google Scholar 

  • Ismaïli K, Hall M, Piefz A et al (2006) Primary VUR detected in neonates with a history of fetal renal pelvis dilatation. J Pediatr 148:222–227

    Article  PubMed  Google Scholar 

  • Ismaili K, Piepsz A (2013) The antenatal detected pelvi-ureteric junction stenosis: advances in renography and strategy of management. Pediatr Radiol 43:428–435

    Article  PubMed  Google Scholar 

  • Jaswon MS, Dibble L, Puri S et al (1999) Prospective study of outcome in antenatally diagnosed renal pelvis dilatation. Arch Dis Child Fetal Neonatal Ed 80:F135–F138

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kousidis G, Thomas DFM, Morgan H, Haider N et al (2008) The long term follow-up of prenatally detected PUV: a 10 to 23 year follow-up study. BJU Int 102:1020–1024

    Article  PubMed  Google Scholar 

  • Kumar S, Walla S, Ikpene O (2012) Post natal outcome of prenatally diagnosed renal pelvic dilatation. Prenat Diagn 32:519–522

    Article  PubMed  Google Scholar 

  • Lee RS, Cendron M, Kinnamon DD et al (2006) Antenatal hydronephrosis as a predictor of postnatal outcomes: a meta-analysis. Pediatrics 118:586–593

    Article  PubMed  Google Scholar 

  • Liu HYA, Dhillon HK, Yeung CK et al (1994) Clinical outcome of prenatally diagnosed primary megaureters. J Urol 152:614–617

    Article  CAS  PubMed  Google Scholar 

  • Marra G, Barbieri G, Dell’Agnola CA et al (1994) Congenital renal damage associated with primary vesicoureteral reflux detected prenatally in male infants. J Pediatr 124:726–730

    Article  CAS  PubMed  Google Scholar 

  • McAleer IM, Kaplan GW (1999) Renal function before and after pyeloplasty: does it improve? J Urol 162:1041–1044

    Article  CAS  PubMed  Google Scholar 

  • Morris RK, Malin GL, Khan KS, Kitty MD (2009) Antenatal US to predict post natal renal function in congenital lower urinary tract obstruction: systematic review of test accuracy. BJOG 116:1290–1299

    Article  CAS  PubMed  Google Scholar 

  • Nogarède C, Tondeur M, Piepsz A (2010) Normalized residual activity and output efficiency in case of early furosemide injection in children. Nucl Med Commun 31:355–358

    PubMed  Google Scholar 

  • Nguyen HT, Herndon CDA, Cooper C, Gatti J, Kirsch A, Kokorowski P et al (2014) The Society for fetal urology consensus statement on the evaluation and management of antenatal hydronephrosis. J Pediatr Urol 6:212–231

    Article  Google Scholar 

  • Pates JA, Dashe JS (2006) Prenatal diagnosis and management of hydronephrosis. Early Hum Dev 82:3–8

    Article  PubMed  Google Scholar 

  • Piepsz A, Kuyvenhoven J, Tondeur HH (2002) Normalized residual activity: usual values and robustness of the method. J Nucl Med 43:33–38

    PubMed  Google Scholar 

  • Piepsz A, Ham HR (2006) Pediatric applications of renal nuclear medicine. Semin Nucl Med 36:16–35

    Article  PubMed  Google Scholar 

  • Piepsz A (2011) Antenatal detection of pelviureteric junction stenosis : main controversies. Semin Nucl Med 41:11–19

    Article  PubMed  Google Scholar 

  • Piepsz A, Tondeur M, Nogarède C et al (2011) Can severely impaired cortical transit predict which children with pelvi-ureteric junction stenosis detected antenatally might benefit from pyeloplasty ? Nucl Med Commun 32:199–205

    Article  PubMed  Google Scholar 

  • Piepsz A, Gordon I, Brock J 3rd et al (2009) Round table on the management of renal pelvic dilatation in children. J Pediatr Urol 5:437–444

    Article  PubMed  Google Scholar 

  • Piepsz A (2009). The predictive value of the renogram. Eur J Nucl Med Mol Imaging 36:1661–1664

    Article  PubMed  Google Scholar 

  • Prigent A, Cosgriff P, Gates GF et al (1999) Consensus report on quality control of quantitative measurements of renal function obtained from renogram : International Consensus Committee for the Scientific Committee of Radionuclides in Nephrourology. Semin Nucl Med 29:146–159

    Article  CAS  PubMed  Google Scholar 

  • Quirino IG, Diniz JSS, Bouazada MCF et al (2012) Clinical course of 822 children with prenatally detected nephron-uropathies. Clin J Amer Soc Nephrol 17:444–451

    Article  Google Scholar 

  • Rabelo EAS, Oliveira EA, Silva JMP et al (2006) US progression of prenatally detected MDK. Urology 68:1098–1112

    Article  Google Scholar 

  • Renkema KY, Winyard PJ, Skovorodkin IN et al (2011) Novel perspectives for investigating CAKUT. Nephrol Dial Transplant 26:3843–3851

    Article  PubMed  Google Scholar 

  • Riccabona M, Avni FE, Blickman JG, Dacher JN, Darge K, Lobo ML, Willi UV (2008) Imaging recommendations in paediatric uroradiology: minutes of the ESPR workgroup session on urinary tract infection, fetal hydronephrosis, urinary tract US and voiding cystourethrography. Pediatr Radiol 38:138–145

    Article  PubMed  Google Scholar 

  • Riccabona M, Avni EF, Blickman JG et al (2009) Imaging recommendations in paediatric uroradiology. Minutes of the ESPR uroradiology task force session on childhood obstructive uropathy, high-grade fetal hydronephrosis, childhood haematuria, and urolithiasis in childhood. ESPR Annual Congress, Edinburgh, UK, June 2008. Pediatr Radiol 39:891–898

    Article  PubMed  Google Scholar 

  • Salem YH, Majd M, Rushton HG (1995) Outcome analysis of pediatric pyeloplasty as a function of patient age presentation and differential renal function. J Urol 154:1889–1893

    Article  CAS  PubMed  Google Scholar 

  • Schlotmann A, Clorius J, Clorius SN (2009) Diuretic renography in hydronephrosis: renal tissue tracer predicts functional course and thereby need for surgery. Eur J Nucl Med Mol Imaging 36:1665–1673

    Article  PubMed  Google Scholar 

  • Selzman AA, Elder JS (1995) Contralateral vesicoureteral reflux in children with a multicystic kidney. J Urol 153:1252–1254

    Article  CAS  PubMed  Google Scholar 

  • Shimada K, Matsumoto F, Kawagoe M, Matsui F (2007) Urological emergency in neonates with congenital hydronephrosis. Int J Urol 14:388–392

    Article  PubMed  Google Scholar 

  • Shukla AR, Cooper J, Paytel RK, Carr MC, Canning DA, Zderic SA, Snyder HM (2005) Prenatally detected primary megaureter: a role for extended follow-up. J Urol 173:1353–1356

    Article  PubMed  Google Scholar 

  • Smith T, Gordon I (1998) An update of radiopharmaceutical schedules in children. Nucl Med Commun 19:1023–1036

    Article  CAS  PubMed  Google Scholar 

  • Stabin M, Taylor A Jr, Eshima D et al (1992) Radiation Dosimetry for technetium-99m-MAG3, technetium-99m-DTPA, and iodine-131-OIH based on human biodistribution studies. J Nucl Med 33:33–40

    PubMed  CAS  Google Scholar 

  • Thorup J, Jokela R, Cortes D, Nielsen OH (2003) The results of 15-years of consistent strategy in treating antenatally suspected PUJ obstruction. BJU Int 91:850–852

    Article  CAS  PubMed  Google Scholar 

  • Tibballs JM, De Bruyn R (1996) Primary vesicoureteric reflux: how useful is postnatal ultrasound? Arch Dis Child 75:444–447

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Uphadhyay J, Bolduc S, Braga L, Fahrat W et al (2002) Impact of prenatal diagnosis on the morbidity associated with ureterocele management. J Urol 167:2560–2565

    Article  Google Scholar 

  • Van Savage JG, Mesrobian HG (1995) The impact of prenatal US on the morbidity and outcome of patients with renal duplication abnormalies. J Urol 153:768–770

    Article  PubMed  Google Scholar 

  • Van Eeide AM, Hentgent MH, de Jond TPVM et al (2007) VUR in children with prenatally detected hydronephrosis. Ultrasound Obstet Gynecol 29:463–469

    Article  Google Scholar 

  • Walsh G, Dubbins PA (1996) Antenatal renal pelvis dilatation: a predictor of vesicoureteral reflux? AJR 167:897–900

    Article  CAS  PubMed  Google Scholar 

  • Weinberg B, Yeung N (1998) US sign of intermittent dilatation of the renal collecting system in ten patients with VUR. J Clin Ultrasound 26:65–68

    Article  CAS  PubMed  Google Scholar 

  • Wiesel A, Queisser-Luft A, Clementi M, Bianca S, Stoll C (2005) Prenatal detection of congenital renal malformations by fetal ultrasonographic examination: an analysis of 709,030 births in 12 Europeans countries. Eur J Med Genetics 48:131–144

    Article  CAS  Google Scholar 

  • Wollenberg A, Neuhaus T, Willi UV, Wisser J (2005) Outcome of fetal renal dilatation diagnosed during the third trimester. Ultrasound Obstet Gynecol 25:483–488

    Article  CAS  PubMed  Google Scholar 

  • Yerkes EB, Adams MC, Pope JC et al (1999) Does every patient with prenatal hydronephrosis need voiding cystourethrography. J Urol 162:1218–1220

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatric Radiology, Jeanne de Flandre Hospital, Lille University Hospital, 59037, Lille, France

    Freddy Avni MD, PhD & Rene-Hilaire Priso MD

  2. Department of Radio-Isotopes, CHU Saint-Pierre, Rue Haute 322, 1000, Brussels, Belgium

    Marianne Tondeur MD

Authors
  1. Freddy Avni MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marianne Tondeur MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rene-Hilaire Priso MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Freddy Avni MD, PhD .

Editor information

Editors and Affiliations

  1. Division of Pediatric Radiology, University Hospital, LKH Graz, Graz, Austria

    Michael Riccabona

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Avni, F., Tondeur, M., Priso, RH. (2018). Upper Urinary Tract Dilatation in Newborns and Infants and the Postnatal Work-Up of Congenital Uro-nephropathies. In: Riccabona, M. (eds) Pediatric Urogenital Radiology. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/978-3-319-39202-8_26

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-39202-8_26

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-39200-4

  • Online ISBN: 978-3-319-39202-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation