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Epidemiology of Hepatocellular Carcinoma

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Pathology and Epidemiology of Cancer

Abstract

There is considerable variability in incidence and mortality of hepatocellular carcinoma (HCC). Much is known about its causes, which include infections with hepatitis B (HBV) and hepatitis C (HCV) viruses, alcohol, and obesity. Vaccination for HBV has significantly reduced the incidence of HCC in developed countries, but it remains the major etiologic factor in underdeveloped geographic areas. HCV infection, for which no effective vaccine has been discovered so far, has become the main etiological factor for HCC in Western countries and Japan, often in association with alcohol abuse. The increased median survival of patients with liver cirrhosis due to improved medical care represents another indirect cause of higher incidence of HCC in developed countries.

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Author information

Authors and Affiliations

  1. S.Orsola-Malpighi Teaching Hospital, Addarii Institute of Oncology, 40138, Bologna, Italy

    Francesca Giunchi, Francesco Vasuri & Michelangelo Fiorentino

Authors
  1. Francesca Giunchi
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  2. Francesco Vasuri
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  3. Michelangelo Fiorentino
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Corresponding author

Correspondence to Michelangelo Fiorentino .

Editor information

Editors and Affiliations

  1. Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston, Massachusetts, USA

    Massimo Loda

  2. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA

    Lorelei A. Mucci

  3. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA

    Megan L. Mittelstadt

  4. King’s College London, Guy’s Hospital, London, United Kingdom

    Mieke Van Hemelrijck

  5. Department of Pathology, Dana-Farber Cancer Institute and Brigham & Women’s Hospital, Boston, Massachusetts, USA

    Maura Bríd Cotter

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Giunchi, F., Vasuri, F., Fiorentino, M. (2017). Epidemiology of Hepatocellular Carcinoma. In: Loda, M., Mucci, L., Mittelstadt, M., Van Hemelrijck, M., Cotter, M. (eds) Pathology and Epidemiology of Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-35153-7_23

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  • DOI: https://doi.org/10.1007/978-3-319-35153-7_23

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-35151-3

  • Online ISBN: 978-3-319-35153-7

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