Regulated tRNA Cleavage in Biology and Medicine: Roles of tRNA Modifications
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Transfer RNAs (tRNAs) play a key role in translating genomic information and regulating gene expression. tRNA cleavage is an evolutionarily conserved phenomenon serving versatile functions in different organisms. The size distribution and abundance of tRNA-derived fragments suggests that tRNA modifications play important roles in mechanisms that regulate tRNA cleavage and degradation. Here, we discuss the importance of posttranscriptional modifications in controlling processing of tRNAs and describe the functions of tRNA-derived fragments in cell physiology and pathophysiology.
KeywordstRNA Modifications Ribonuclease Angiogenin tRNA cleavage
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