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Effects of Renal Denervation on Intermediate End Points

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Interventional Therapies for Secondary and Essential Hypertension

Part of the book series: Updates in Hypertension and Cardiovascular Protection ((UHCP))

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Abstract

Sympathetic nervous system (SNS) activity constitutes an important pathway involved in the initiation and progression of the hypertensive disease. Sympathetic overactivity increases in parallel with hypertension stages, with acceleration of vascular, cardiac, and renal damage, while it is implicated in the pathogenesis of arrhythmias and glucose metabolism regulation. The effect of SNS modulation by means of renal denervation (RDN) on the intermediate end points related to the heart, kidney, arteries, arrhythmias, and glucose metabolism has been investigated in experimental and human studies. Although the majority of the studies suggest beneficial impact of RDN therapy on target organ damage, further well-designed studies are needed in order to fully understand the relation between neuromodulation and surrogate end point alterations in high-risk hypertensive patients.

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Abbreviations

BP:

Blood pressure

dRHTN:

Drug-resistant hypertension

LV:

Left ventricle

RDN:

Renal denervation

SNS:

Sympathetic nervous system

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Authors and Affiliations

  1. 1st Cardiology Clinic, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece

    Kyriakos Dimitriadis, Dimitrios Tousoulis & Costas Tsioufis

Authors
  1. Kyriakos Dimitriadis
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  2. Dimitrios Tousoulis
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  3. Costas Tsioufis
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Correspondence to Kyriakos Dimitriadis .

Editor information

Editors and Affiliations

  1. First Cardiology Clinic, National and Kapodistrian University of Athens, Athens, Greece

    Costas Tsioufis

  2. Department of Nephrology and Hypertension, University Hospital Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

    Roland E. Schmieder

  3. IRCCS Istituto Auxologico Italiano, University Milano-Bicocca, Milano Monza, Italy

    Giuseppe Mancia

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Dimitriadis, K., Tousoulis, D., Tsioufis, C. (2016). Effects of Renal Denervation on Intermediate End Points. In: Tsioufis, C., Schmieder, R., Mancia, G. (eds) Interventional Therapies for Secondary and Essential Hypertension. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-319-34141-5_17

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  • DOI: https://doi.org/10.1007/978-3-319-34141-5_17

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-34140-8

  • Online ISBN: 978-3-319-34141-5

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