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Do Dietary Factors Influence Tendon Metabolism?

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 920)

Abstract

There is very little direct research to conclusively prove the relevance of diet in primary tendinopathies, however it seems prudent to ask whether our current knowledge about the impact of nutrition on collagen metabolism could be useful in assessing, preventing, or treating tendinopathy. The objective of this chapter is to discuss the potential impact (negative or positive) that nutrition may have on the metabolism of tendons by summarizing the related research. The chapter briefly discusses the roles that specific vitamins, amino acids, lipids, and antioxidants have in various processes of the body that may be directly or indirectly related to tenocyte metabolism.

Keywords

  • Diet
  • Tendon
  • Nutrition
  • Vitamin
  • Tendinopathy
  • Lipid
  • Amino acid
  • Antioxidant

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Abbreviations

OA:

Osteoarthritis

IGF-1:

Insulin-like Growth Factor-1

TGF-beta:

Transforming Growth Factor-Beta

FGF2:

Fibroblast Growth Factor 2

COL1A1:

Collagen, type 1, alpha 1

rER:

Rough Endoplasmic Reticulum

MMP1:

Matrix Metalloproteinase-1

PGE2:

Prostaglandin E2

IL1:

Interleukin-1

UV Light:

Ultraviolet Light

LDL:

Low-density Lipoprotein

oxLDL:

Oxidized Low-density Lipoprotein

COL3A1:

Collagen, type 3, alpha 1

MMP2:

Matrix Metalloproteinase-2

ROS:

Reactive Oxygen Species

GTE:

Green Tea Extract

mRNA:

Messenger RibonucleicAcid

References

  1. Scott A, Backman L, Speed C (2015) Tendinopathy-update on pathophysiology. J Orthop Sports Phys Ther 45(11):833–841. doi:10.2519/jospt.2015.5884

    CrossRef  PubMed  Google Scholar 

  2. Birch HL, Thorpe CT, Rumian AP (2013) Specialisation of extracellular matrix for function in tendons and ligaments. Muscles Ligaments Tendons J 3(1):12–22. doi:10.11138/mltj/2013.3.1.012

    PubMed  PubMed Central  Google Scholar 

  3. Schechtman H, Bader DL (1997) In vitro fatigue of human tendons. J Biomech 30(8):829–835

    CAS  CrossRef  PubMed  Google Scholar 

  4. Ohlhorst SD, Russell R, Bier D et al (2013) Nutrition research to affect food and a healthy lifespan. Adv Nutr 4(5):579–584. doi:10.3945/an.113.004176

    CrossRef  PubMed  PubMed Central  Google Scholar 

  5. Molnar JA, Underdown MJ, Clark WA (2014) Nutrition and chronic wounds. Adv Wound Care 3(11):663–681. doi:10.1089/wound.2014.0530

    CrossRef  Google Scholar 

  6. Clark N (1997) Nancy Clark’s sports nutrition guidebook, 2nd edn. Human Kinetics, Champaign, p 4

    Google Scholar 

  7. Benjamin M, Kaiser E, Milz S (2008) Structure-function relationships in tendons: a review. J Anat 212(3):211–228. doi:10.1111/j.1469-7580.2008.00864.x

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  8. Kostrominova TY, Brooks SV (2013) Age-related changes in structure and extracellular matrix protein expression levels in rat tendons. Age 35(6):2203–2214. doi:10.1007/s11357-013-9514-2

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  9. Chhabra N. Biochemistry for medics web site. http://www.namrata.co/collagen-synthesistypes-and-composition-part-2/. Accessed 4 Dec 2015

  10. More on Collagen. http://www.uic.edu/classes/peri/peri612/persyb6.pdf. Accessed 4 Dec 2015

  11. Collagen Metabolism. Medscape: multispecialty. http://www.medscape.com/viewarticle/423231_2. Accessed 4 Dec 2015

  12. Mertens MT, Gertner E (2011) Rheumatic manifestations of scurvy: a report of three recent cases in a major urban center and a review. Semin Arthritis Rheum 41(2):286–290. doi:10.1016/j.semarthrit.2010.10.005

    CrossRef  PubMed  Google Scholar 

  13. Kipp DE, McElvain M, Kimmel DB, Akhter MP, Robinson RG, Lukert BP (1996) Scurvy results in decreased collagen synthesis and bone density in the guinea pig animal model [abstract]. Bone 18(3):281–288. http://www.ncbi.nlm.nih.gov/pubmed/8703585. Accessed 9 Nov 2015: PMID: 8703585

    CAS  CrossRef  PubMed  Google Scholar 

  14. Kipp DE, Schwarz RI (1990) Effectiveness of isoascorbate versus ascorbate as an inducer of collagen synthesis in primary avian tendon cells. J Nutr 120(2):185–189

    CAS  PubMed  Google Scholar 

  15. Russell JE, Manske PR (1991) Ascorbic acid requirement for optimal flexor tendon repair in vitro [abstract]. J Orthop Res 9(5):714–719, http://www.ncbi.nlm.nih.gov/pubmed/1870035. Accessed 4 Dec 2015

    CAS  CrossRef  PubMed  Google Scholar 

  16. Omeroğlu S, Peker T, Türközkan N, Omeroğlu H (2009) High-dose vitamin C supplementation accelerates the Achilles tendon healing in healthy rats. Arch Orthop Trauma Surg 129(2):281–286. doi:10.1007/s00402-008-0603-0

    CrossRef  PubMed  Google Scholar 

  17. Poulsen RC, Zarei A, Sabokbar A, Hulley PA (2013) Tendon, a vitamin D-responsive tissue – why the British weather may not just be bad for your bones![abstract]. 94:A20

    Google Scholar 

  18. Dobak J, Grzybowski J, Liu FT, Landon B, Dobke M (1994) 1,25-dihydroxyvitamin D3 increases collagen production in dermal fibroblasts [abstact]. J Dermatol Sci 8(1):18–24. http://www.ncbi.nlm.nih.gov/pubmed/7947488. Accessed 29 Nov 2015

    Google Scholar 

  19. Yaron I, Meyer FA, Weisman Y, Yaron M (1993) Effect of 1,25-dihydroxyvitamin D3 on interleukin 1 beta actions and cell growth in human synovial fibroblast cultures [abstract]. J Rheumatol 20(9):1527–1532, http://www.ncbi.nlm.nih.gov/pubmed/8164209. Accessed 29 Nov 29 2015

    CAS  PubMed  Google Scholar 

  20. Hosokawa Y, Hosokawa I, Shindo S, Ozaki K, Matsuo T (2015) Calcitriol suppressed inflammatory reactions in IL-1β-stimulated human periodontal ligament cells. Inflammation 38(6):2252–2258. doi:10.1007/s10753-015-0209-y

    CAS  CrossRef  PubMed  Google Scholar 

  21. Chen YC, Ninomiya T, Hosoya A, Hiraga T, Miyazawa H, Nakamura H (2012) 1α,25-dihydroxyvitamin D3 inhibits osteoblastic differentiation of mouse periodontal fibroblasts. Arch Oral Biol 57(5):453–459. doi:10.1016/j.archoralbio.2011.10.005

    Google Scholar 

  22. Angeline ME, Ma R, Pascual-garrido C et al (2014) Effect of diet-induced vitamin D deficiency on rotator cuff healing in a rat model. Am J Sports Med 42(1):27–34. doi:10.1177/0363546513505421

    CrossRef  PubMed  Google Scholar 

  23. Barbosa AW, Benevides GP, Alferes LM, Salomao EM, Gomes-Marcondes MC, Gomes L (2012) A leucine-rich diet and exercise effect the biomechanical characteristics of the digital flexor tendon in rats after nutritional recovery. Amino Acids 42(1):329–336. doi:10.1007/s00726-010-0810-1

    CAS  CrossRef  PubMed  Google Scholar 

  24. Vieira CP, De oliveira LP, Da ré guerra F, Dos santos de almeida M, Marcondes MC, Pimentel ER (2015) Glycine improves biochemical and biomechanical properties following inflammation of the achilles tendon. Anat Rec (Hoboken) 298(3):538–545. doi:10.1002/ar.23041

    CAS  CrossRef  Google Scholar 

  25. Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, König D (2015) Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr 114(8):1237–1245. doi:10.1017/S0007114515002810

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  26. Grewal N, Thornton GM, Behzad H et al (2014) Accumulation of oxidized LDL in the tendon tissues of C57BL/6 or apolipoprotein E knock-Out mice that consume a high fat diet: potential impact on tendon health. In: Screen HR (ed) PLoS One 9(12):e114214. doi:10.1371/journal.pone.0114214

    Google Scholar 

  27. Lü J-M, Lin PH, Yao Q, Chen C (2010) Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. J Cell Mol Med 14(4):840–860. doi:10.1111/j.1582-4934.2009.00897.x

    CrossRef  PubMed  Google Scholar 

  28. Godic A, Poljšak B, Adamic M, Dahmane R (2014) The role of antioxidants in skin cancer prevention and treatment. Oxid Med Cell Longev 2014:860479. doi:10.1155/2014/860479

    CrossRef  PubMed  PubMed Central  Google Scholar 

  29. Rutter K, Sell DR, Fraser N et al (2003) Green tea extract suppresses the age-related increase in collagen crosslinking and fluorescent products in C57BL/6 mice. Int J Vitam Nutr Res 73(6):453–460

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  30. Lewis JS, Sandford FM (2009) Rotator cuff tendinopathy: is there a role for polyunsaturated fatty acids and antioxidants? J Hand Ther 22(1):49–55. doi:10.1197/j.jht.2008.06.007

    CrossRef  PubMed  Google Scholar 

  31. World Health Organization. Nutrient requirements and dietary guidelines. Available at: http://www.who.int/nutrition/publications/nutrient/en/. Accessed on 7 Dec 2015

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Scott, A., Nordin, C. (2016). Do Dietary Factors Influence Tendon Metabolism?. In: Ackermann, P., Hart, D. (eds) Metabolic Influences on Risk for Tendon Disorders. Advances in Experimental Medicine and Biology, vol 920. Springer, Cham. https://doi.org/10.1007/978-3-319-33943-6_27

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