Abstract
Tuberous sclerosis complex (TSC) consists of autosomal dominant dysgenetic disorders characterized by hamartomas and neoplasms involving the central nervous system (CNS) and various other tissues.
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References
Northrup H, Krueger DA. International Tuberous Sclerosis Complex Consensus Group. Tuberous sclerosis complex diagnostic criteria update: recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference. Pediatr Neurol. 2013;49:243–54.
Kotulska K, Jurkiewicz E, Domanska-Pakiela D, Grajkowska W, Mandera M, Borkowska J, et al. Epilepsy in newborns with tuberous sclerosis complex. Eur J Paediatr Neurol. 2014;18:714–21.
Ruppe V, Dilsiz P, Reiss CS, Carlson C, Devinsky O, Zagzag D, et al. Developmental brain abnormalities in tuberous sclerosis complex: a comparative tissue analysis of cortical tubers and perituberal cortex. Epilepsia. 2014;55:539–50.
Chalifoux JR, Perry N, Katz JS, Wiggins GC, Roth J, Miles D, et al. The ability of high field strength 7-T magnetic resonance imaging to reveal previously uncharacterized brain lesions in patients with tuberous sclerosis complex. J Neurosurg Pediatr. 2013;11:268–73.
Pinto Gama HP, da Rocha AJ, Braga FT, da Silva CJ, Maia Jr AC, de Campos Meirelles RG, et al. Comparative analysis of MR sequences to detect structural brain lesions in tuberous sclerosis. Pediatr Radiol. 2006;36:119–25.
Hewer E, Vajtai I. Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis. Clin Neuropathol. 2015;34:128–31.
Barrows BD, Rutkowski MJ, Gultekin SH, Parsa AT, Tihan T. Evidence of ambiguous differentiation and mTOR pathway dysregulation in subependymal giant cell astrocytoma. Turk Patoloji Derg. 2012;28:95–103.
Chan JA, Zhang H, Roberts PS, Jozwiak S, Wieslawa G, Lewin-Kowalik J, et al. Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. J Neuropathol Exp Neurol. 2004;63:1236–42.
Jozwiak S, Mandera M, Mlynarski W. Natural history and current treatment options for subependymal giant cell astrocytoma in tuberous sclerosis complex. Semin Pediatr Neurol. 2015;22:274–81.
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Tihan, T., Adesina, A.M. (2016). Tuberous Sclerosis Complex. In: Adesina, A., Tihan, T., Fuller, C., Poussaint, T. (eds) Atlas of Pediatric Brain Tumors. Springer, Cham. https://doi.org/10.1007/978-3-319-33432-5_28
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DOI: https://doi.org/10.1007/978-3-319-33432-5_28
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