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A Multi-Modal CMOS Sensor Platform Towards Personalized DNA Sequencing

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Smart Sensors and Systems

Abstract

Precision medicine requires scalable bio-instrument for a personalized DNA sequencing, which can be label-free, cost-efficient, and high-throughput. This chapter mainly presents three kinds of CMOS-based label-free sensors, including: (1) a high-sensitivity ion-sensitive field-effect transistor (ISFET) sensor with pH-to-time-to-voltage conversion (pH-TVC); (2) a dual-mode sensor with image and chemical modes for high accuracy; and (3) a THz metamaterial sensor with electrical resonance detection. The developed CMOS multi-modal sensor platform can show a scaled solution for future personalized DNA sequencing.

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Authors and Affiliations

  1. School of EEE, Nanyang Technological University, Singapore, Singapore

    Yu Jiang, Xu Liu, Xiwei Huang, Yang Shang, Mei Yan & Hao Yu

Authors
  1. Yu Jiang
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  2. Xu Liu
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  3. Xiwei Huang
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  4. Yang Shang
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  5. Mei Yan
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  6. Hao Yu
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Corresponding author

Correspondence to Hao Yu .

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Editors and Affiliations

  1. Center for Integrated Smart Sensors, Yuseong-gu, Daejeon, Korea (Republic of)

    Chong-Min Kyung

  2. System LSI Research Center, Kyushu University, Fukuoka, Japan

    Hiroto Yasuura

  3. Circuits and Systems Division, Tsinghua University, Beijing, China

    Yongpan Liu

  4. National Tsing Hua University , Hsichu, Taiwan

    Youn-Long Lin

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Jiang, Y., Liu, X., Huang, X., Shang, Y., Yan, M., Yu, H. (2017). A Multi-Modal CMOS Sensor Platform Towards Personalized DNA Sequencing. In: Kyung, CM., Yasuura, H., Liu, Y., Lin, YL. (eds) Smart Sensors and Systems. Springer, Cham. https://doi.org/10.1007/978-3-319-33201-7_2

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  • DOI: https://doi.org/10.1007/978-3-319-33201-7_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-33200-0

  • Online ISBN: 978-3-319-33201-7

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