Pruritus, Pain and Other Abnormal Skin Sensations
Pruritus (itch) can be defined as an unpleasant cutaneous sensation that leads to the need to scratch. Pain is defined by the International Association for the Study of Pain (IASP) as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage”. Hence, itch and pain are different sensations, with different clinical aspects, different origins and different pathways. However, they share common mechanisms and they can overlap and have interactions.
KeywordsPruritus Itch Pain Paresthesia Dysesthesia Sensitization Gate control Pruriceptor Nociceptor Neuropeptide Nerve Brain
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