Pruritus pp 363-377 | Cite as


  • Caroline Gaudy-MarquesteEmail author


Histamine, first characterized nearly a century ago, is a key mediator of numerous biologic reactions including “allergic” ones, some of which are involved in usual dermatosis pathophysiology. Four types of receptors (H1, H2, H3, and H4) are individualized to date. Most of the effects of Histamine in allergic disease are mediated by the H1 receptors. Beside it role in early allergic response to antigen, Histamine also stimulate cytokines production and expression of cell-adhesion molecules and class II antigens, thus contributing to the late allergic response. Antihistamines and especially H1 ones are widely used in dermatological practice mainly in front of itching dermatosis. H1-antihistamines are an efficient treatment of urticaria where their efficacy is widely evidenced. Second generation molecules should be the first prescribed due to low side effects and best pharmacokinetic profile. All second generation molecules are equivalent in term of efficacy and most of them are free of sedative and cardiac side effects.


Histamine Antihistamines Urticarial Itch Treatment Side effects Skin Atopic dermatitis Mastocyte Allergy 


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Copyright information

© Springer-Verlag London 2016

Authors and Affiliations

  1. 1.Department of Dermatology and Skin CancerTimoneMarseilleFrance

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