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Pruritus pp 355-357 | Cite as

Topical Steroids and Immunomodulators

  • Laurent MiseryEmail author
Chapter

Abstract

Topical steroids are frequently used in itchy diseases. They are very effective in inflammatory dermatoses but there is no indication in other conditions because there is no known specific effect on itch. On the contrary, the topical calcineurin tacrolimus and pimecrolimus, that are indicated in atopic dermatitis, have specific effects on itch and could probably used in many other conditions.

Keywords

Itch Pruritus Steroid Topical Immunomodulator Tacrolimus Pimecrolimus TRP Calcineurin 

References

  1. 1.
    Van Laarhoven AI, van der Saman-Mauriks IM, Donders AR, Pronk MC, van de Kerkhof PC, Evers AW. Placebo effects on itch: a meta-analysis of clinical trials of patients with dermatological conditions. J Invest Dermatol. 2015;135:1234–43.CrossRefPubMedGoogle Scholar
  2. 2.
    Evers AW, Bartels DJ, van Laarhoven AI. Placebo and nocebo effects in itch and pain. Handb Exp Pharmacol. 2014;225:205–14.CrossRefPubMedGoogle Scholar
  3. 3.
    Fujii Y, Sengoku T, Takakura S. Repeated topical application of glucocorticoids augments irritant chemical-triggered scratching in mice. Arch Dermatol Res. 2010;302:645–52.CrossRefPubMedGoogle Scholar
  4. 4.
    Yamaura K, Doi R, Suwa E, Ueno K. Repeated application of glucocorticoids exacerbate pruritus via inhibition of prostaglandin D2 production of mast cells in a murine model of allergic contact dermatitis. J Toxicol Sci. 2012;37:1127–34.CrossRefPubMedGoogle Scholar
  5. 5.
    Sher LG, Chang J, Patel IB, Balkrishnan R, Fleischer AB. Relieving the pruritus of atopic dermatitis: a meta-analysis. Acta Derm Venereol. 2012;92:455–61.CrossRefPubMedGoogle Scholar
  6. 6.
    Meurer M, Fölster-Horst R, Wozel G, et al. Pimecrolimus cream in the long-term management of atopic dermatitis in adults: a six-month study. Dermatology. 2002;205:271–7.CrossRefPubMedGoogle Scholar
  7. 7.
    Reitamo S, Van Leent EJ, Ho V, et al. Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone acetate ointment in children with atopic dermatitis. J Allergy Clin Immunol. 2002;109:539–46.CrossRefPubMedGoogle Scholar
  8. 8.
    Stander S, Schürmeyer-Horst F, Luger TA, Weisshaar E. Treatment of pruritic diseases with topical calcineurin inhibitors. Ther Clin Risk Manag. 2006;2:213–8.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Suys E. Randomized study of topical tacrolimus ointment as possible treatment for resistant idiopathic pruritus ani. J Am Acad Dermatol. 2012;66:327–8.CrossRefPubMedGoogle Scholar
  10. 10.
    Goldman D. Tacrolimus ointment for the treatment of steroid-induced rosacea: a preliminary report. J Am Acad Dermatol. 2001;44:995–8.CrossRefPubMedGoogle Scholar
  11. 11.
    Cherill R, Tofte S, MacNaul R, et al. SDZ ASM 981 1% cream is effective in the treatment of chronic irritant hand dermatitis. J Eur Acad Dermatol Venereol. 2000;14 Suppl 1:128.Google Scholar
  12. 12.
    Choi CJ, Nghiem P. Tacrolimus ointment in the treatment of chronic cutaneous graft-versus-host disease: a case series of 18 patients. Arch Dematol. 2001;137:1202–6.CrossRefGoogle Scholar
  13. 13.
    Böhm M, Friedling U, Luger TA, et al. Successful treatment of anogenital lichen sclerosus with topical tacrolimus. Arch Dermatol. 2003;139:922–4.CrossRefPubMedGoogle Scholar
  14. 14.
    Banky JP, Sheridan AT, Storer EL, et al. Successful treatment of epidermolysis bullosa pruriginosa with topical tacrolimus. Arch Dermatol. 2004;140:794–6.CrossRefPubMedGoogle Scholar
  15. 15.
    Aguilar-Bernier M, Bassas-Vila J, Sanz-Munoz S, et al. Succesful treatment of pruritus with topical tacrolimus in a patient with primary biliray cirrhosis. Br J Dermatol. 2005;152:808–9.CrossRefPubMedGoogle Scholar
  16. 16.
    Kuypers DR, Claes K, Evenpoel P, et al. A prospective proof of concept study of the efficacy of tacrolimus ointmenton uraemic pruritus (UP) in patients on chronic dialysis therapy. Nephrol Dial Transplant. 2004;19:1895–901.CrossRefPubMedGoogle Scholar
  17. 17.
    Duque MI, Yosipovitch G, Fleischer AB, et al. Lack of efficacy of tacrolimus ointment O.1% for treatment of hemodialysis-related pruritus: a randomizeddouble-blinded, vehicle-controlled study. J Am Acad Dermatol. 2005;52:519–21.CrossRefPubMedGoogle Scholar
  18. 18.
    Rustin MHA. The safety of tacrolimus ointment for the treatment of atopic dermatitis: a review. Br J Dermatol. 2007;157:861–73.CrossRefPubMedGoogle Scholar
  19. 19.
    Calza AM, Lübbe J. Tacrolimus ointment-associated alcohol intolerance in infants receiving ethanol-conatining medication. Br J Dermatol. 2005;152:569.CrossRefPubMedGoogle Scholar
  20. 20.
    Milingou M, Antille C, Sorg O, Saurat JH, Lübbe J. Alcohol intolerance and facial flushing in patients treated with topical tacrolimus. Arch Dermatol. 2004;140:1542–4.CrossRefPubMedGoogle Scholar
  21. 21.
    Trevisani M, Smart D, Gunthorpe MJ, et al. Ethanol elicits and potentiates nociceptor response via the vanilloid-receptor 1. Nat Neurosci. 2002;5:546–51.CrossRefPubMedGoogle Scholar
  22. 22.
    Stander S, Luger TA. Antipruritic effects of pimecrolimus and tacrolimus. Hautartzt. 2003;54:413–7.Google Scholar
  23. 23.
    Senba E, Katanosaka K, Yajima H, et al. The immunosuppressant FK506 activates capsaicin- and bradykinin-sensitive DRG neurons and cutaneous C-fibers. Neurosci Res. 2004;50:257–62.CrossRefPubMedGoogle Scholar
  24. 24.
    Stander S, Stander H, Seelinger S, Luger TA, Steinhoff M. Topical tacrolimus and pimecrolimus transiently induce neuropeptide release and mast cell degranulation in murine skin. Br J Dermatol. 2007;156:1020–6.CrossRefPubMedGoogle Scholar
  25. 25.
    Pereira U, Boulais N, Lebonvallet N, Pennec JP, Dorange G, Misery L. Mechanisms of the sensory effects of tacrolimus on the skin. Br J Dermatol. 2010;163:70–7.PubMedGoogle Scholar
  26. 26.
    Xie ZQ, Yang GY, Jiang W, Xu ML. Antipruritic mechanisms of pimecrolimus cream for facial dermatitis in adult women patients. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2009;31:27–30.PubMedGoogle Scholar

Copyright information

© Springer-Verlag London 2016

Authors and Affiliations

  1. 1.Laboratory of Neurosciences of Brest, and Department of DermatologyUniversity Hospital, and University of BrestBrestFrance

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