Cancers as a cause of acute or chronic itch are less frequently observed than hematological malignancies but recently non-melanoma skin cancers have been described as the most common type of malignancy-associated itch. Cancers can cause itch by local effects on the tissue or by systemic effects to cancer, by side-effects of treatment and severe xerosis cutis. Itch in the absence of any primary skin disease should be a warning to rule out an underlying malignancy. If suspected a precise dermatological and a general examination are necessary including a thorough medical history, dermatological and physical examination, laboratory tests and radiological diagnostics. In case of non-melanoma skin cancer the whole skin needs to be examined carefully and skin biopsy is frequently needed. If a solid tumor is suspected the whole sequence of investigations including laboratory and technical (e.g. computertomography, magnetic resonance tomography, endoscopy) screening might be necessary to diagnose the underlying cause of itch. Treatment centers on therapy of the underlying malignancy paralleled by symptomatic topical and systemic medications. This chapter summarizes all relevant information on itch in cancers including non-melanoma skin cancer.
KeywordsCancer Itch Malignancy Malignant itch Pruritus
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