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Pruritus pp 13-20 | Cite as

Pruriceptors

  • Ethan A. LernerEmail author
Chapter

Abstract

Pruriceptors are peripheral sensory neurons that have the capacity to sense and respond to pruritogens. These fibers and the receptors, channels and mediators involved in their stimulation are discussed in this chapter. Our focus is on aspects that are most relevant to the clinic and clinical research communities. The potential for new therapeutic agents to inhibit these receptors, channels and mediators and thus the transduction of itch is described.

Keywords

Itch G-protein coupled receptor Cytokine receptor TRP channel Mrgpr Cowhage 

Abbreviations

AITC

Allyl isothiocyanate

BAM8-22

Bovine adrenal medulla 8-22 peptide

BNP

B-type natriuretic peptide

CGRP

Calcitonin gene-related peptide

DAG

Diacylglycerol

DRG

Dorsal root ganglion

GPCR

G-protein coupled receptor

GRPR

Gastrin-releasing peptide receptor

IP3

Inositoltriphosphate

LPA

Lysophosphatidic acid

LPC

Lysophosphatidyl choline

Mrgprs

Mas-related G-protein coupled receptors

NaV

Sodium channel

NGF

Nerve growth factor

NK1

Neurokinin 1 receptor

NPR-A

Natriuretic peptide receptor-A

PARs

Protease-activated receptors

PIP2

Phosphatidylinositol

PKCδ

Phodphokinase Cδ

PLCβ3

Phospholipase Cβ3

TLR

Toll-like receptor

TRP

Transient receptor potential channel

TRPA1

Transient receptor potential ankyrin subfamily member 1

TRPV1

Transient receptor potential channel subfamily V member 1

TRPV4

Transient receptor potential channel subfamily V member 4

TSLP

Thymic stromal lymphopoietin

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Copyright information

© Springer-Verlag London 2016

Authors and Affiliations

  1. 1.Cutaneous Biology Research Center, Department of DermatologyMassachusetts General Hospital and Harvard Medical SchoolCharlestownUSA

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