Pruritus pp 13-20 | Cite as


  • Ethan A. LernerEmail author


Pruriceptors are peripheral sensory neurons that have the capacity to sense and respond to pruritogens. These fibers and the receptors, channels and mediators involved in their stimulation are discussed in this chapter. Our focus is on aspects that are most relevant to the clinic and clinical research communities. The potential for new therapeutic agents to inhibit these receptors, channels and mediators and thus the transduction of itch is described.


Itch G-protein coupled receptor Cytokine receptor TRP channel Mrgpr Cowhage 



Allyl isothiocyanate


Bovine adrenal medulla 8-22 peptide


B-type natriuretic peptide


Calcitonin gene-related peptide




Dorsal root ganglion


G-protein coupled receptor


Gastrin-releasing peptide receptor




Lysophosphatidic acid


Lysophosphatidyl choline


Mas-related G-protein coupled receptors


Sodium channel


Nerve growth factor


Neurokinin 1 receptor


Natriuretic peptide receptor-A


Protease-activated receptors




Phodphokinase Cδ


Phospholipase Cβ3


Toll-like receptor


Transient receptor potential channel


Transient receptor potential ankyrin subfamily member 1


Transient receptor potential channel subfamily V member 1


Transient receptor potential channel subfamily V member 4


Thymic stromal lymphopoietin


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Copyright information

© Springer-Verlag London 2016

Authors and Affiliations

  1. 1.Cutaneous Biology Research Center, Department of DermatologyMassachusetts General Hospital and Harvard Medical SchoolCharlestownUSA

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