Pruritus pp 93-95 | Cite as

Measurement of Itch: Patient-Reported Outcomes

  • Sonja StänderEmail author


As a frequent symptom, chronic pruritus (CP) impacts all age groups. The development and validation of new antipruritic substances in clinical trials are of greater importance than ever due to the absence of specific and cost-effective therapies. At present, there are no standardized, validated tools used for objectively measuring pruritus. Thus, a special interest group of International Forum for the Study of Itch (IFSI) and European Academy of Dermatology and Venereology (EADV) was formed in order to effectively evaluate scoring methods and questionnaires used in clinical trials and routine care. Pruritus intensity scales and methods for assessing patient quality of life are useful instruments currently recommended by the group.


Itch Pruritus Visual analog scale Patient benefit index Quality of life Data bank 


  1. 1.
    Ständer S, Augustin M, Reich A, Blome C, Ebata T, Phan NQ, Szepietowski JC. Pruritus assessment in clinical trials: a consensus paper of the special interest group scoring itch in clinical trials of the International Forum for the Study of Itch (IFSI). Acta Derm Venereol. 2013;93:509–14.CrossRefPubMedGoogle Scholar
  2. 2.
    Ständer S, Zeidler C, Riepe C, Steinke S, Fritz F, Bruland P, Soto-Rey I, Storck M, Agner T, Augustin M, Blome C, Dalgard F, Evers AWM, Garcovich S, Gonçalo M, Lambert J, Legat FJ, Leslie T, Misery L, Raap U, Reich A, Şavk E, Streit M, Serra-Baldrich E, Szepietowski J, Wallengren J, Weisshaar E, Dugas M. European EADV network on assessment of severity and burden of pruritus (PruNet): first meeting on outcome tools. JEADV. 2015; in press doi:  10.1111/jdv.13296.Google Scholar
  3. 3.
    Phan NQ, Blome C, Fritz F, Gerss J, Reich A, Ebata T, et al. Assessment of pruritus intensity: prospective study on validity and reliability of the visual analogue scale, numerical rating scale and verbal rating scale in 471 patients with chronic pruritus. Acta Derm Venereol. 2012;92:502–7.CrossRefPubMedGoogle Scholar
  4. 4.
    Reich A, Heisig M, Phan NQ, Taneda K, Takamori K, Takeuchi S, et al. Visual analogue scale: evaluation of the instrument for the assessment of pruritus. Acta Derm Venereol. 2012;92:497–501.CrossRefPubMedGoogle Scholar
  5. 5.
    Furue M, Ebata T, Ikoma A, Takeuchi S, Kataoka Y, Takamori K, et al. Verbalizing Extremes of the Visual Analogue Scale for Pruritus: A Consensus Statement. Acta Derm Venereol. 2013;93:214–5.Google Scholar
  6. 6.
    Schneider G, Driesch G, Heuft G, Evers S, Luger TA, Ständer S. Psychosomatic cofactors and psychiatric comorbidity in patients with chronic itch. Clin Exp Dermatol. 2006;31:762–7.CrossRefPubMedGoogle Scholar
  7. 7.
    Tessari G, Dalle Vedove C, Loschiavo C, Tessitore N, Rugiu C, Lupo A, et al. The impact of pruritus on the quality of life of patients undergoing dialysis: a single centre cohort study. J Nephrol. 2009;22:241–8.PubMedGoogle Scholar
  8. 8.
    Ware Jr JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30:473–83.CrossRefPubMedGoogle Scholar
  9. 9.
    Gandek B, Ware JE, Aaronson NK, Apolone G, Bjorner JB, Brazier JE, et al. Cross-validation of item selection and scoring for the SF-12 Health Survey in nine countries: results from the IQOLA Project. International Quality of Life Assessment. J Clin Epidemiol. 1998;51:1171–8.CrossRefPubMedGoogle Scholar
  10. 10.
    Finlay A, Khan G. Dermatology Life Quality Index (DLQI) – a simple practical measure for routine clinical use. Clin Exp Dermatol. 1994;19:210–6.CrossRefPubMedGoogle Scholar
  11. 11.
    Reich A, Hrehorów E, Szepietowski JC. Pruritus is an important factor negatively influencing the well-being of psoriatic patients. Acta Derm Venereol. 2010;90:257–63.CrossRefPubMedGoogle Scholar
  12. 12.
    Desai NS, Poindexter GB, Miller Monthrop Y, Bendeck SE, Swerlick RA, Chen SC. A pilot quality-of-life instrument for pruritus. J Am Acad Dermatol. 2008;259:234–44.CrossRefGoogle Scholar
  13. 13.
    Krause K, Kessler B, Weller K, Veidt J, Chen SC, Martus P, et al. German version of Itchy Qol: validation and initial clinical findings. Acta Dermato Venereol. 2013;93:562–8.Google Scholar

Copyright information

© Springer-Verlag London 2016

Authors and Affiliations

  1. 1.Center for Chronic Pruritus (KCP), Department of DermatologyUniversity Hospital of MünsterMünsterGermany

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