Host Defense Peptides and Their Advancements in Translational Staphylococcus aureus Research

  • Sarah C. Mansour
  • Robert E.W. Hancock
  • Michael OttoEmail author


Staphylococcus aureus is responsible for a multitude of infections ranging from skin and soft tissue infections to more severe invasive diseases. In response to S. aureus, host defense peptides (HDPs) are produced as nature’s own sentinel effector molecules. HDPs are small, often cationic, molecules that possess numerous biological activities, such as antimicrobial activity, cellular recruitment, anti-inflammatory properties, and wound healing, all of which play a role in controlling S. aureus infections. In hopes of capitalizing on the powerful anti-infective functions of HDPs, there has been a considerable amount of interest in deriving HDP-based therapeutics. Here, we highlight current advancements in HDP research, constraints to commercial development, and solutions for safer and more feasible HDP-based therapies against S. aureus.


Antimicrobial Activity Minimal Inhibitory Concentration Toxic Shock Syndrome Atopic Dermatitis Patient Aureus Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg (outside the USA) 2016

Authors and Affiliations

  • Sarah C. Mansour
    • 1
    • 2
  • Robert E.W. Hancock
    • 1
  • Michael Otto
    • 2
    Email author
  1. 1.Centre for Microbial Diseases and Immunity Research, Department of Microbiology and ImmunologyUniversity of British ColumbiaVancouverCanada
  2. 2.Pathogen Molecular Genetics Section, Laboratory of BacteriologyNational Institute of Allergy and Infectious Diseases, National Institutes of HealthBethesdaUSA

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