Abstract
Spectral-domain Optical coherence tomography (SD-OCT) is becoming one of the most important modalities for the noninvasive assessment of retinal eye diseases. As the number of acquired SD-OCT volumes increases, automating the SD-OCT image analysis is becoming increasingly relevant. This study aimed to assess the reproducibility of an automatic algorithm to quantify the macular atrophy area in patients with Juvenile Macular Degeneration.
Fifteen patients (30 eyes) suffering from Juvenile Macular Degeneration underwent two SD-OCT scanning in two different visits (baseline and 1-week follow-up). En-face SD-OCT analysis was performed to quantify the area of macular atrophy by using an automated algorithm. Reproducibility for the macular atrophy area were calculated by the intraclass correlation coefficients (ICC).
The reproducibility, as assessed with the ICC, was excellent on both the original area scale (ICC > 0.98) and on the square-root scale (ICC>0.97). There was no significant difference between scans acquired during the two visits.
This study confirms that SD-OCT fundus images can be used to reproducibly quantitate areas of macular atrophy area in patients with Juvenile Macular Degeneration.
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References
Kiss CG, Geitzenauer W, Simader C, Gregori G, Schmidt-Erfurth U. Evaluation of ranibizumab-induced changes in high-resolution optical coherence tomographic retinal morphology and their impact on visual function. Invest Ophthalmol Vis Sci. 2009;50(5):2376-83. doi:10.1167/iovs.08-2017.
Legarreta JE, Gregori G, Knighton RW, Punjabi OS, Lalwani GA, Puliafito CA. Three-dimensional spectral-domain optical coherence tomography images of the retina in the presence of epiretinal membranes. Am J Ophthalmol. 2008;145(6):1023-30. doi:10.1016/j.ajo.2008.01.014.
Gregori G, Wang F, Rosenfeld PJ, Yehoshua Z, Gregori NZ, Lujan BJ et al. Spectral domain optical coherence tomography imaging of drusen in nonexudative age-related macular degeneration. Ophthalmology. 2011;118(7):1373-9. doi:10.1016/j.ophtha.2010.11.013.
Yehoshua Z, Rosenfeld PJ, Gregori G, Feuer WJ, Falcao M, Lujan BJ et al. Progression of geographic atrophy in age-related macular degeneration imaged with spectral domain optical coherence tomography. Ophthalmology. 2011;118(4):679-86. doi:10.1016/j.ophtha.2010.08.018.
Stargardt K. Über familiäre, progressive Degeneration in der Maculagegend des Auges. Graefes Arch Clin Exp Ophthalmol. 1909;71(3):534-50.
Testa F, Rossi S, Sodi A, Passerini I, Di Iorio V, Della Corte M et al. Correlation between Photoreceptor Layer Integrity and Visual Function in Patients with Stargardt Disease: Implications for Gene Therapy. Invest Ophthalmol Vis Sci. 2012;53(8):4409-15. doi:10.1167/iovs.11-8201.
Lee W, Noupuu K, Oll M, Duncker T, Burke T, Zernant J et al. The external limiting membrane in early-onset Stargardt disease. Invest Ophthalmol Vis Sci. 2014;55(10):6139-49. doi:10.1167/iovs.14-15126.
Huang WC, Cideciyan AV, Roman AJ, Sumaroka A, Sheplock R, Schwartz SB et al. Inner and outer retinal changes in retinal degenerations associated with ABCA4 mutations. Invest Ophthalmol Vis Sci. 2014;55(3):1810-22. doi:10.1167/iovs.13-13768.
Park JC, Collison FT, Fishman GA, Allikmets R, Zernant J, Liu M et al. Objective Analysis of Hyperreflective Outer Retinal Bands Imaged by Optical Coherence Tomography in Patients With Stargardt Disease. Invest Ophthalmol Vis Sci. 2015;56(8):4662-7. doi:10.1167/iovs.15-16955.
Greenstein VC, Schuman AD, Lee W, Duncker T, Zernant J, Allikmets R et al. Near-infrared autofluorescence: its relationship to short-wavelength autofluorescence and optical coherence tomography in recessive stargardt disease. Invest Ophthalmol Vis Sci. 2015;56(5):3226-34. doi:10.1167/iovs.14-16050.
Klein R, Lewis RA, Meyers SM, Myers FL. Subretinal neovascularization associated with fundus flavimaculatus. Arch Ophthalmol. 1978;96(11):2054-7.
Ahlers C, Gotzinger E, Pircher M, Golbaz I, Prager F, Schutze C et al. Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography. Invest Ophthalmol Vis Sci. 2010;51(4):2149-57. doi:10.1167/iovs.09-3817.
Fleiss JL. The design and analysis of clinical experiments. Wiley classics library ed. Wiley classics library. New York: Wiley; 1999.
Martin Bland J, Altman D. Statistical methods for assessing agreement between two methods of clinical measurement. The lancet. 1986;327(8476):307-10.
Fleiss JL. Statistical methods for rates and proportions. 2d ed. Wiley series in probability and mathematical statistics. New York: Wiley; 1981.
Melillo P, Testa F, Rossi S, Di Iorio V, Orrico A, Auricchio A et al. En-face spectral-domain optical coherence tomography for the monitoring of lesion area progression in Stargardt disease. Invest Ophthalmol Vis Sci. accepted.
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Melillo, P. et al. (2016). Reproducibility of en-face Optical Coherence Tomography Imaging for Macular Atrophy Area Evaluation in Juvenile Macular Degeneration. In: Kyriacou, E., Christofides, S., Pattichis, C. (eds) XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016. IFMBE Proceedings, vol 57. Springer, Cham. https://doi.org/10.1007/978-3-319-32703-7_50
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DOI: https://doi.org/10.1007/978-3-319-32703-7_50
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