Abstract
The objective of the current chapter is to evaluate the potential utility of classic psychedelics including dimethyltryptamine (found in the Amazonian plant decoction ayahuasca), lysergic acid diethylamide (LSD), mescaline (found in peyote and other psychoactive cacti), and psilocybin (found in certain mushrooms) in addressing rational suicide among the elderly. An overview of the sociopolitical history of classic psychedelics is presented, followed by an examination of empirical findings pertaining to rational suicide. This chapter concludes that classic psychedelics may counteract rational suicide among the elderly by promoting the perception that life is worth living even in the face of great adversity and encourages future study on this important topic.
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References
Vollenweider FX, Kometer M. The neurobiology of psychedelic drugs: implications for the treatment of mood disorders. Nature Rev Neurosci. 2010;11:642–51.
El-Seedi HR, De Smet PA, Beck O, et al. Prehistoric peyote use: alkaloid analysis and radiocarbon dating of archaeological specimens of Lophophora from Texas. J Ethnopharmacol. 2005;101:238–42.
Grinspoon L, Bakalar JB. Psychedelic drugs reconsidered. New York: Basic Books; 1979.
Nichols DE. Hallucinogens. Pharmacol Ther. 2004;101:131–81.
Schultes RE. Hallucinogens of plant origin. Science. 1969;163:245–54.
Schultes RE, Hoffman A, Rätsch C. Plants of the gods: their sacred, healing, and hallucinogenic powers. Rev. edn. Rochester: Healing Arts Press; 2001.
Grob CS, Greer GR, Mangini M. Hallucinogens at the turn of the century: an introduction. J Psychoactive Drugs. 1998;30:315–9.
Masters REL, Houston J. The varieties of psychedelic experience. New York: Holt, Rinehart & Winston; 1966.
Lee MA, Shlain B. Acid dreams: the complete social history of LSD—The CIA, the Sixties, and Beyond. Rev. edn. New York: Grove Press; 1992.
Stevens J. Storming heaven: LSD and the American dream. New York: The Atlantic Monthly Press; 1987.
Gable RS. Toward a comparative overview of dependence potential and acute toxicity of psychoactive substances used nonmedically. Am J Drug Alcohol Abuse. 1993;19:263–81.
Gable RS. Comparison of acute lethal toxicity of commonly abused psychoactive substances. Addiction. 2004;99:686–96.
Nutt DJ, King LA, Phillips LD. Drug harms in the UK: a multicriteria decision analysis. Lancet. 2010;376:1558–65.
Derbyshire D. Healing trip: how psychedelic drugs could help treat depression. The Guardian. 2014. http://www.theguardian.com/society/2014/oct/05/healing-trip-psychedelic-drugs-treat-depression. Accessed 10 Jan 2016.
Griffiths RR, Richards WA, McCann U, et al. Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacology (Berl). 2006;187:268–83.
Griffiths RR, Richards WA, Johnson MW, et al. Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later. J Psychopharmacol. 2008;22:621–32.
Griffiths RR, Johnson MW, Richards WA, et al. Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects. Psychopharmacology (Berl). 2011;218:649–55.
Grof S, Goodman LE, Richards WA, et al. LSD-assisted psychotherapy in patients with terminal cancer. Int Pharmacopsychiatry. 1973;8:129–44.
Pahnke WN. The psychedelic mystical experience in the human encounter with death. Harv Theol Rev. 1969;62:1–21.
Kast E. Attenuation of anticipation: a therapeutic use of lysergic acid diethylamide. Psychiatr Q. 1967;41:646–57.
Kast EC, Collins VJ. Study of lysergic acid diethylamide as an analgesic agent. Anesth Analg. 1964;43:285–91.
Grob CS, Danforth AL, Chopra GS, et al. Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer. Arch Gen Psychiatry. 2011;68:71–8.
Gasser P, Holstein D, Michel Y, et al. Safety and efficacy of lysergic acid diethylamide-assisted psychotherapy for anxiety associated with life-threatening diseases. J Nerv Ment Dis. 2014;202:513–20.
Hawton K, van Heeringen K. Suicide. Lancet. 2009;373:1372–81.
Bogenschutz MP, Johnson MW. Classic hallucinogens in the treatment of addictions. Prog Neuropsychopharmacol Biol Psychiatry. 2016;64:250–8.
Bogenschutz MP, Pommy JM. Therapeutic mechanisms of classic hallucinogens in the treatment of addictions: from indirect evidence to testable hypotheses. Drug Test Anal. 2012;4:543–55.
Krebs TS, Johansen PØ. Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials. J Psychopharmacol. 2012;26:994–1002.
Johnson MW, Garcia-Romeu A, Cosimano MP, et al. Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction. J Psychopharmacol. 2014;28:983–92.
Bogenschutz MP, Forcehimes AA, Pommy JA, et al. Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept study. J Psychopharmacol. 2015;29:289–99.
Thomas G, Lucas P, Capler NR, et al. Ayahuasca-assisted therapy for addiction: results from a preliminary observational study in Canada. Curr Drug Abuse Rev. 2013;6:30–42.
Hendricks PS, Clark CB, Johnson MW, et al. Hallucinogen use predicts reduced recidivism among substance-involved offenders under community corrections supervision. J Psychopharmacol. 2014;28:62–6.
Osório Fde L, Sanches RF, Macedo LR, et al. Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report. Rev Bras Psiquiatr. 2015;37:13–20.
Sanches RF, de Lima OF, Dos Santos RG, et al. Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a SPECT study. J Clin Psychopharmacol. 2016;36:77–81.
van Dierendonck D. Spirituality as an essential determinant for the good life, its importance relative to self-determinant psychological needs. J Happiness Stud. 2012;13:685–700.
Rasic DT, Belik SL, Elias B, et al. Spirituality, religion and suicidal behavior in a nationally representative sample. J Affect Disord. 2009;114:32–40.
Rasic D, Robinson JA, Bolton J, et al. Longitudinal relationships of religious worship attendance and spirituality with major depression, anxiety disorders, and suicidal ideation and attempts: findings from the Baltimore epidemiologic catchment area study. J Psychiatr Res. 2011;45:848–54.
Weber SR, Pargament KI. The role of religion and spirituality in mental health. Curr Opin Psychiatry. 2014;27:358–63.
Soler J, Elices M, Franquesa A, et al. Exploring the therapeutic potential of ayahuasca: acute intake increases mindfulness-related capacities. Psychopharmacology (Berl). 2016;233(5):823–9.
Catalino LI, Fredrickson BL. A Tuesday in the life of a flourisher: the role of positive emotional reactivity in optimal mental health. Emotion. 2011;11:938–50.
Carhart-Harris RL, Leech R, Hellyer PJ, et al. The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs. Front Hum Neurosci. 2014;8:20.
Whitfield-Gabrieli S, Ford JM. Default mode network activity and connectivity in psychopathology. Annu Rev Clin Psychol. 2012;8:49–76.
MacLean KA, Johnson MW, Griffiths RR. Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness. J Psychopharmacol. 2011;25:1453–61.
Segal DL, Marty MA, Meyer WJ, et al. Personality, suicidal ideation, and reasons for living among older adults. J Gerontol B Psychol Sci Soc Sci. 2012;67:159–66.
Hendricks PS, Thorne CB, Clark CB, et al. Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. J Psychopharmacol. 2015;29:280–8.
Grob CS, Bossis AP, Griffiths RR. Use of the classic hallucinogen psilocybin for treatment of existential distress associated with cancer. In: Carr BI, Steel J, editors. Psychological aspects of cancer. New York: Springer; 2013.
Byock I. Evidence-based therapies for persistent suffering. Psychol. 2014;27:677–8.
Nutt DJ, King LA, Nichols DE. Effects of schedule I drug laws on neuroscience research and treatment innovation. Nature Rev Neurosci. 2013;14:577–85.
Hendricks PS, Johnson MW, Griffiths RR. Psilocybin, psychological distress, and suicidality. J Psychopharmacol. 2015;29:1041–3.
Johnson MW, Richards WA, Griffiths RR. Human hallucinogen research: guidelines for safety. J Psychopharmacol. 2008;22:603–20.
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Hendricks, P.S., Grob, C.S. (2017). Classic Psychedelics and Rational Suicide in the Elderly: Exploring the Potential Utility of a Reemerging Treatment Paradigm. In: McCue, R., Balasubramaniam, M. (eds) Rational Suicide in the Elderly. Springer, Cham. https://doi.org/10.1007/978-3-319-32672-6_14
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DOI: https://doi.org/10.1007/978-3-319-32672-6_14
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