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Pharmacology of Drugs in Aging

Abstract

General principles for appropriate prescribing for the elderly are described in this chapter. Age-related changes in pharmacokinetics (absorption, distribution, metabolism, and distribution) with normal aging and in frail elderly patients are presented. Tools to identify potentially inappropriate medications in the elderly, including the American Geriatrics Society Beers Criteria and the STOPP/START criteria, are described. The prescription cascade, where a side effect of a medication is misinterpreted as a new medical condition leading to the introduction of another drug, is also described. The association between geriatric syndromes and medication use is presented as well as strategies to reduce fall risk-increasing medications. Assessment and review of medications in frail elderly patients should be done every 6 months.

Keywords

  • Fall Risk
  • Clinical Decision Support System
  • Serum Creatinine Concentration
  • Inappropriate Medication
  • Medication Reconciliation

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Abbreviations

ADE:

Adverse drug events

ADL:

Activity of daily living

AGS:

American Geriatrics Society

FRID:

Fall risk-increasing drug

ISMP:

Institute for Safe Medication Practices

MAI:

Medication appropriateness index

PIM:

Potentially inappropriate medication

START:

Screening tool to alert doctors to right treatment

STOPP:

Screening tool of older person’s prescriptions

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Correspondence to Louise Mallet BScPharm, PharmD, CGP, FESCP .

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Mallet, L. (2016). Pharmacology of Drugs in Aging. In: Huang, A., Mallet, L. (eds) Medication-Related Falls in Older People. Adis, Cham. https://doi.org/10.1007/978-3-319-32304-6_5

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  • DOI: https://doi.org/10.1007/978-3-319-32304-6_5

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