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Inappropriate Medications and Risk of Falls in Older Adults

Abstract

Among older adults, potentially inappropriate medications have been associated with an increased risk of falls and hip fractures (a proxy measure for serious falls). In addition to the medications listed in other chapters in this book, skeletal muscle relaxants (SMR), antiepileptic drugs (AED), opioids, and combinations of medications affecting the central nervous system (CNS) have been shown to increase the risk of serious falls. Moreover, this increased risk is even more pronounced among older adults with a previous history of falls and hip fractures. This chapter will summarize literature highlighting the specific risks of these medications, with an emphasis on rigorously designed observational studies.

Keywords

  • Inappropriate Medication
  • Adjust Risk Ratio
  • Skeletal Muscle Relaxant
  • Central Nervous System Adverse Effect
  • Standardize Daily Dose

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Abbreviations

AED:

Antiepileptic drug

ARR:

Adjusted risk ratio

AOR:

Adjusted odds ratio

CI:

Confidence interval

CNS:

Central nervous system

CYP:

Cytochrome P450

IRR:

Incident risk ratio

NCQA:

National Committee for Quality Assurance

OR:

Odds ratio

PIM:

Potentially inappropriate medications

RR:

Relative risk

SMR:

Skeletal muscle relaxants

US:

United States

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Correspondence to Jennifer Greene Naples PharmD .

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Naples, J.G., Hanlon, J.T., Ruby, C.M., Greenspan, S.L. (2016). Inappropriate Medications and Risk of Falls in Older Adults. In: Huang, A., Mallet, L. (eds) Medication-Related Falls in Older People. Adis, Cham. https://doi.org/10.1007/978-3-319-32304-6_14

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  • DOI: https://doi.org/10.1007/978-3-319-32304-6_14

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  • Publisher Name: Adis, Cham

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