Introduction to Radiation Biology When Treating Hyperproliferative Benign Diseases
For decades, a low-dose irradiation with X-rays has clinically been documented to exert a beneficial effect on hyperproliferative disorders like the Dupuytren disease (DD) and Ledderhose disease (LD). By contrast, experimental studies to unravel underlying cellular and molecular mechanisms are still at their early stages. Recent data, however, indicate the involvement of radiation-sensitive target cells like mitotic fibroblasts/myofibroblasts, induction of free radicals to impair proliferative activity of these cells, interference with growth factors and cytokines and a reduction of activated immune cells interacting with the inflammatory and proliferative processes. We here aim at briefly describing mechanisms contributing to a modulation of fibrogenic and inflammatory components upon exposure to ionizing radiation.
KeywordsLow-dose radiation therapy Hyperproliferative diseases Fibroblasts/myofibroblast Cytokines Growth factors Antiproliferative effect Anti-inflammatory effect
Acknowledgements and Conflict of Interest Statement
This work has received funding from the European Atomic Energy Community’s Seventh Framework Programme under grant agreement no FP7-249689 (European Network of Excellence, DoReMi) and the German Federal Ministry of Education and Research (GREWIS, 02NUK017F). The authors have no conflict of interest to declare.
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