Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Amant F, Cadron I, Fuso L, Berteloot P, de Jonge E, Jacomen G, et al. Endometrial carcinosarcomas have a different prognosis and pattern of spread compared to high-risk epithelial endometrial cancer. Gynecol Oncol. 2005;98:274–80.
FIGO Committee on Gynecologic Oncology. FIGO staging for carcinoma of the vulva, cervix, and corpus uteri. Int J Gynaecol Obstet. 2014;125(2):97–8.
D’Angelo E, Prat J. Pathology of mixed Müllerian tumours. Best Pract Res Clin Obstet Gynaecol. 2011;25(6):705–18.
Sreenan JJ, Hart WR. Carcinosarcomas of the female tract. A pathological study of 29 metastatic tumors: further evidence for the dominant role of the epithelial component and the conversion theory of histogenesis. Am J Surg Pathol. 1995;19:666–74.
Gorai I, Yanagibashi T, Taki A, Udagawa K, Miyagi E, Nakazawa T, Hirahara F, Nagashima Y, Minaguchi H. Uterine carcinosarcoma is derived from a single stem cell: an in vitro study. Int J Cancer. 1997;72:821–7.
Fujii H, Yoshida M, Gong ZX, Matsumoto T, Hamano Y, Fukunaga M, Hruban RH, Gabrielson E, Shirai T. Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotic diversity. Cancer Res. 2000;60:114–20.
Amant F, Vloeberghs V, Woestenborghs H, Moerman P, Vergote I. Transition of epithelial toward mesenchymal differentiation during ovarian carcinosarcoma tumorigenesis. Gynecol Oncol. 2003;90:372–7.
Tanaka Y, Terai Y, Kawaguchi H, Fujiwara S, Yoo S, Tsunetoh S, Takai M, Kanemura M, Tanabe A, Ohmichi M. Prognostic impact of EMT(epithelial-mesenchymal-transition)-related protein expression in endometrial cancer. Cancer Biol Ther. 2013;14(1):13–9.
Murray S, Linardou H, Mountzios G, Manokoulos M, Markaki S, Eleutherakis-Papaiakovou E, Dimopoulos MA, Papadimitriou CA. Low frequency of somatic mutations in uterine sarcomas: a molecular analysis and review of the literature. Mutat Res. 2010;686:68–73.
De Jong RA, Nijman HW, Wilbrandi TF, Reyners AK, Boezen HM, Hollema H. Molecular markers and clinical behavior of uterine carcinosarcomas: focus on the epithelial component. Mol Pathol. 2011;24(10):1368–79.
Growdon W, Roussel B, Scialabba V, Foster R, Dias-Santagata D, Iafrate A, Ellisen L, Tambouret R, Rueda B, Borger D. Tissue-specific signatures of activating PI3CA and RAS mutations in carcinosarcomas of gynecologic origin. Gynecol Oncol. 2011;121:212–7.
Cimbaluk D, Rotmensch J, Scudiere J, Gown A, Bitterman P. Uterine carcinosarcoma: Immunohistochemical studies on tissue microarrays with focus on potential therapeutic targets. Gynecol Oncol. 2007;105:138–44.
Garg G, Shah J, Kumar S, Bryant C, Munkarah A, Morris R. Ovarian and uterine carcinosarcomas: a comparative analysis of prognostic variables and survival outcomes. Int J Gynecol Cancer. 2010;20:888–94.
Rauh-Hain JA, Shoni M, Shorge JO, Goodman A, Horowitz N, Del Carmen M. Prognostic determinants in patients with uterine and ovarian carcinosarcomas. J Reprod Med. 2013;58:297–304.
Ferguson SE, Tornos C, Hummer A, Barakat RR, Soslow RA. Prognostic features of surgical stage I uterine carcinosarcoma. Am J Surg Pathol. 2007;31(11):1653–61.
Rauh-Hain JA, Growdon WB, Rodriguez N, Goodman AK, Boruta II DM, Schorge JO, Horowitz NS, Del Carmen MG. Carcinosarcoma of the ovary: a case control study. Gynecol Oncol. 2011;121:477–81.
Nemani D, Mitra N, Guo M, et al. Assessing the effects of lymphadenectomy and radiation therapy in patients with uterine carcinosarcoma: a SEER analysis. Gynecol Oncol. 2008;III:82–8.
Vorgias G, Fotiou S. The role of lymphadenectomy in uterine carcinomas: a critical literature review Arch. Gynecol Obstet. 2010;282:659–64.
Tanner EJ, Leitao Jr MM, Garg K. The role of cytoreductive surgery for newly diagnosed-stage uterine carcinosarcoma. Gynecol Oncol. 2011;25:751–60.
Reed NS, Mangioni C, Malmstrom H, et al. Phase III randomised study to evaluate the role of adjuvant pelvic radiotherapy III the treatment of uterine sarcomas stages I and II: an European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group Study (protocol 55874). Eur J Cancer. 2008;44:808–18 [Erratum appears in Eur J Cancer. 2008;44:1612].
Wright JD, Seshan VE, Shah M, Schiff PB, Burke WM, Cohen CJ, Herzog TJ. The role of radiation in improving survival for early-stage carcinosarcoma and leiomyosarcoma. Am J Obstet Gynecol. 2008;199(5):531–8.
Clayton Smith D, Kenneth Macdonald O, Gaffney DK, et al. The impact of adjuvant radiation therapy on survival in women with uterine carcinosarcoma. Radiother Oncol. 2008;88:227–32.
Wolfson AH, Brady MF, Rocereto T, Mannel RS, Lee YC, Futoran RJ, et al. A gynecologic oncology group randomized phase III trial of whole abdominal irradiation (WAI) vs. cisplatin-ifosfamide and mesna (CIM) as post-surgical therapy in stage I–IV carcinosarcoma (CS) of the uterus. Gynecol Oncol. 2007;107:177–85.
Omura GA, Major FJ, Blessing JA, Sedlacek TV, Thigpen JT, Creasman WT, et al. A randomized study of adriamycin with and without dimethyl triazenoimidazolecarboxamide in advanced uterine sarcomas. Cancer. 1983;52:626–32.
Pautier P, Floquet A, Gladieff L, et al. A randomized clinical trial of adjuvant chemotherapy with doxorubicin, ifosfamide and cisplatin followed by radiotherapy versus radiotherapy alone in patients with localized uterine sarcomas (SARCGYN study). Ann Oncol. 2013;24(4):1099–104.
Sutton G, Kauderer J, Carson LF, Lentz SS, Whitney CW, Gallion H. Adjuvant ifosfamide and cisplatin in patients with completely resected stage I or II carcinosarcomas (mixed mesodermal tumors) of the uterus: a Gynecologic Oncology Group study. Gynecol Oncol. 2005;96:630–4.
Powell MA, Filiaci VL, Rose PG, Mannel RS, Hanjani P, DeGeest K, et al. Phase II evaluation of paclitaxel and carboplatin in the treatment of carcinosarcoma of the uterus: a Gynecologic Oncology Group Study. J Clin Oncol. 2010;28:2727–31.
Makker V, Abu-Rustum NR, Alektiar KM, et al. A retrospective assessment of outcomes of chemotherapy-based versus radiation-only adjuvant treatment for completely resected stage I-IV uterine carcinosarcoma. Gynecol Oncol. 2008;3:249–54.
NCCN Guidelines Version 3.2012 Endometrial carcinoma. http://www.nccn.org/professionals/physician_gls/pdf/uterine.pdf. Accessed on 19 Sept 2012.
Duska LR, Garett A, Eltabbakh MD, Oliva E, Penson R, Fuller A. Paclitaxel and Platinum Chemotherapy for malignant mixed mullerian tumors of the ovary. Gynecol Oncol. 2002;85:459–63.
Shylasree TS, Bryant A, Athavale R. Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma. Cochrane Database Syst Rev. 2013;2:CD006246.
Homesley HD, Filiaci V, Markman M, Bitterman P, Eaton L, Kilgore LC, et al. Phase III trial of ifosfamide with or without paclitaxel in advanced uterine carcinosarcoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2007;25:526–31.
Sutton G, Brunetto VL, Kilgore L, Soper JT, McGehee R, Olt G, et al. Trial of ifosfamide with or without cisplatin in carcinosarcoma of the uterus: a gynecologic oncology group study. Gynecol Oncol. 2000;79:147–53.
Morrow CP, Bundy BN, Hoffman J, Sutton G, Homesley H. Adriamycin chemotherapy for malignant mixed mesodermal tumor of the ovary. A Gynecologic Oncology Group Study. Am J Clin Oncol. 1986;9(1):24–6.
Pectasides D, Pectasides E, Papaxoinis G, Xiros N, Sykiotis C, Papachristodoulou A, Tountas N, Panayiotides J, Economopoulos T, et al. Combination chemotherapy with carboplatin, paclitaxel and pegylated liposomal doxorubicin for advanced or recurrent carcinosarcoma of the uterus: clinical experience of a single institution. Gynecol Oncol. 2008;110:299–303.
Galaal K, van der Heijden E, Godfrey K, et al. Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma. Cochrane Database Syst Rev. 2013;2:CD006812.
Hoskins PI, Le N, Ellard S, et al. Carboplatin plus paclitaxel for advanced or recurrent uterine malignant mixed mullerian tumors. The British Columbia Cancer Agency experience. Gynecol Oncol. 2008;108:58–62.
Huh WK, Sill MW, Darcy KM, et al. Efficacy and safety of imatinib mesylate (Gleevec®) and immunohistochemical expression of c-Kit and PDGFR-β in a Gynecologic Oncology Group Phase Il Trial in women with recurrent or persistent carcinosarcomas of the uterus. Gynecol Oncol. 2010;117:248–54.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Berton-Rigaud, D., Frenel, J.S., Devouassoux-Shisheboran, M., Ray-Coquard, I. (2017). Gynecological Carcinosarcomas. In: Pujade-Lauraine, E., Ray-Coquard, I., Lécuru, F. (eds) Ovarian Cancers. Springer, Cham. https://doi.org/10.1007/978-3-319-32110-3_17
Download citation
DOI: https://doi.org/10.1007/978-3-319-32110-3_17
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-32108-0
Online ISBN: 978-3-319-32110-3
eBook Packages: MedicineMedicine (R0)