Skip to main content

Hypertension and Subjective Cognitive Failures

  • Chapter
  • First Online:
  • 1262 Accesses

Part of the book series: Updates in Hypertension and Cardiovascular Protection ((UHCP))

Abstract

Hypertension, one of the main risk factors for cardiovascular disease, is thought to play a crucial role in the pathophysiology of cognitive impairment. Studies have associated hypertension with subjective cognitive failures – concerns about a person’s own cognitive function − which are considered as a probable early sign of cognitive dysfunction. Subjective cognitive failures reflect a pathological process occurring in the brain that has been associated with hypertension and with other cardiovascular risk factors and which may be assessed by neuropsychological evaluation and brain imaging studies. The underlying cerebral structural change associated with cognitive decline is a consequence of the cerebral small vessel disease induced by high blood pressure and may be detected on magnetic resonance imaging as white matter hyperintensities, cerebral microbleeds, lacunar infarcts or enlarged perivascular spaces. This chapter aims to discuss current available evidence on subjective cognitive failures and their relationship with hypertension and to highlight the best antihypertensive treatment for this condition, focusing on the antihypertensive drugs proven to have a positive effect on the incidence of dementia.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V et al (2012) Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380:2095–2128

    Article  PubMed  Google Scholar 

  2. Nichols M, Townsend N, Scarborough P, Rayner M (2014) Cardiovascular disease in Europe 2014: epidemiological update. Eur Heart J 35:2950–2959

    Article  PubMed  Google Scholar 

  3. Hajjar I, Kotchen JM, Kotchen TA (2006) Hypertension: trends in prevalence, incidence, and control. Annu Rev Public Health 27:465–490

    Article  PubMed  Google Scholar 

  4. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC et al (2011) The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7:270–279

    Article  PubMed  PubMed Central  Google Scholar 

  5. Begum A, Dewey M, Hassiotis A, Prince M, Wessely S, Stewart R et al (2014) Subjective cognitive complaints across the adult life span: a 14-year analysis of trends and associations using the 1993, 2000 and 2007 English Psychiatric Morbidity Surveys. Psychol Med 44:1977–1987

    Article  CAS  PubMed  Google Scholar 

  6. Stewart R, Godin O, Crivello F, Maillard P, Mazoyer B, Tzourio C et al (2011) Longitudinal neuroimaging correlates of subjective memory impairment: 4-year prospective community study. Br J Psychiatry 198:199–205

    Article  PubMed  Google Scholar 

  7. Montenegro M, Montejo P, Claver-Martín MD, Reinoso AI, De Andrés-Montes ME, García-Marín A et al (2013) Relación de las quejas de memoria con el rendimiento de memoria, el estado de ánimo y variables sociodemográficas en adultos jóvenes. Rev Neurol 57:396–404

    PubMed  Google Scholar 

  8. Eckerström M, Skoogh J, Rolstad S, Göthlin M, Steineck G, Johansson B et al (2013) Sahlgrenska Academy Self-reported Cognitive Impairment Questionnaire (SASCI-Q)-a research tool discriminating between subjectively cognitively impaired patients and healthy controls. Int Psychogeriatr 25:420–430

    Article  PubMed  Google Scholar 

  9. Montejo P, Montenegro M, Fernandez MA, Maestu F (2011) Subjective memory complaints in the elderly: prevalence and influence of temporal orientation, depression and quality of life in a population-based study in the city of Madrid. Aging Ment Health 15:85–96

    Article  PubMed  Google Scholar 

  10. Miranda B, Madureira S, Verdelho A, Ferro J, Pantoni L, Salvadori E et al (2008) Self-perceived memory impairment and cognitive performance in an elderly independent population with age-related white matter changes. J Neurol Neurosurg Psychiatry 79:869–873

    Article  CAS  PubMed  Google Scholar 

  11. Zlatar ZZ, Moore RC, Palmer BW, Thompson WK, Jeste DV (2014) Cognitive complaints correlate with depression rather than concurrent objective cognitive impairment in the successful aging evaluation baseline sample. J Geriatr Psychiatry Neurol 27:181–187

    Article  PubMed  PubMed Central  Google Scholar 

  12. Buckley R, Saling MM, Ames D, Rowe CC, Lautenschlager NT, Macaulay SL et al (2013) Factors affecting subjective memory complaints in the AIBL aging study: biomarkers, memory, affect, and age. Int Psychogeriatr 25:1307–1315

    Article  CAS  PubMed  Google Scholar 

  13. Scuteri A, Tesauro M, Guglini L, Lauro D, Fini M, Di Daniele N et al (2013) Aortic stiffness and hypotension episodes are associated with impaired cognitive function in older subjects with subjective complaints of memory loss. Int J Cardiol 169:371–377

    Article  PubMed  Google Scholar 

  14. Triantafyllidi H, Arvaniti C, Lekakis J, Ikonomidis I, Siafakas N, Tzortzis S et al (2009) Cognitive impairment is related to increased arterial stiffness and microvascular damage in patients with never-treated essential hypertension. Am J Hypertens 22:525–530

    Article  PubMed  Google Scholar 

  15. Sierra C, Doménech M, Camafort M, Coca A (2012) Hypertension and mild cognitive impairment. Curr Hypertens Rep 14:548–555

    Article  CAS  PubMed  Google Scholar 

  16. Sierra C, Coca A (2014) Brain damage. In: Mancia G, Grassi G, Redon J (eds) Manual of hypertension of the European Society of Hypertension, 2nd edn. Informa Healthcare, London, pp 177–189

    Chapter  Google Scholar 

  17. Van Norden AGW, van Uden IWM, de Laat KF, Gons RAR, Kessels RPC, van Dijk EJ et al (2013) Cerebral microbleeds are related to subjective cognitive failures: the RUN DMC study. Neurobiol Aging 34:2225–2230

    Article  PubMed  Google Scholar 

  18. Van Norden AGW, Fick WF, de Laat KF, van Uden IWM, van Oudheusden LJB, Tendolkar I et al (2008) Subjective cognitive failures and hippocampal volume in elderly with white matter lesions. Neurology 71:1152–1159

    Article  PubMed  Google Scholar 

  19. Kearney-Schwartz A, Rossignol P, Bracard S, Felblinger J, Fay R, Boivin JM et al (2009) Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints. Stroke 40:1229–1236

    Article  PubMed  Google Scholar 

  20. Jia Z, Mohammed W, Qiu Y, Hong X, Shi H (2014) Hypertension increases the risk of cerebral microbleed in the territory of posterior cerebral artery: a study of the association of microbleeds categorized on a basis of vascular territories and cardiovascular risk factors. J Stroke Cerebrovasc Dis 23:e5–e11

    Article  PubMed  Google Scholar 

  21. Uiterwijk R, Huijts M, Staals J, Duits A, Gronenschild E, Kroon AA et al (2014) Subjective cognitive failures in patients with hypertension are related to cognitive performance and cerebral microbleeds. Hypertension 64:653–657

    Article  CAS  PubMed  Google Scholar 

  22. Carey CL, Kramer JH, Josephson SA, Mungas D, Reed BR, Schuff N et al (2008) Subcortical lacunes are associated with executive dysfunction in cognitively normal elderly. Stroke 39:397–402

    Article  PubMed  Google Scholar 

  23. Jokinen H, Gouw AA, Madureira S, Ylikoski R, van Straaten ECW, van der Flier WM et al (2011) Incident lacunes influence cognitive decline: the LADIS study. Neurology 76:1872–1878

    Article  CAS  PubMed  Google Scholar 

  24. Baune BT, Roesler A, Knecht S, Berger K (2009) Single and combined effects of cerebral white matter lesions and lacunar infarctions on cognitive function in an elderly population. J Gerontol A Biol Sci Med Sci 64:118–124

    Article  PubMed  Google Scholar 

  25. Potter GM, Doubal FN, Jackson CA, Chappell FM, Sudlow CL, Dennis MS et al (2015) Enlarged perivascular spaces and cerebral small vessel disease. Int J Stroke 10(3):376–381

    Article  PubMed  Google Scholar 

  26. Maclullich AMJ, Wardlaw JM, Ferguson KJ, Starr JM, Seckl JR, Deary IJ et al (2004) Enlarged perivascular spaces are associated with cognitive function in healthy elderly men. J Neurol Neurosurg Psychiatry 75:1519–1523

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Huijts M, Duits A, van Oostenbrugge RJ, Kroon AA, de Leeuw PW, Staals J et al (2013) Accumulation of MRI markers of cerebral small vessel disease is associated with decreased cognitive function. A study in first-ever lacunar stroke and hypertensive patients. Front Aging Neurosci 5:72

    Article  PubMed  PubMed Central  Google Scholar 

  28. Levi Marpillat N, Macquin-Mavier I, Tropeano AI, Bachoud-Levi AC, Maison P (2013) Antihypertensive classes, cognitive decline and incidence of dementia: a network meta-analysis. J Hypertens 31:1073–1082

    Article  CAS  PubMed  Google Scholar 

  29. Coca A (2013) Hypertension and vascular dementia in the elderly: the potential role of anti-hypertensive agents. Curr Med Res Opin 29:1045–1054

    Article  CAS  PubMed  Google Scholar 

  30. Godin O, Tzourio C, Maillard P, Mazoyer B, Dufouil C (2011) Antihypertensive treatment and change in blood pressure are associated with the progression of white matter lesion volumes: the Three-City (3C)-Dijon Magnetic Resonance Imaging Study. Circulation 123:266–273

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Antonio Coca .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Monteagudo, E., Sierra, C., Coca, A. (2016). Hypertension and Subjective Cognitive Failures. In: Coca, A. (eds) Hypertension and Brain Damage. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-319-32074-8_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-32074-8_14

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-32072-4

  • Online ISBN: 978-3-319-32074-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics