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Usefulness of Subclassification of Follicular Lesion of Undetermined Significance

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Book cover Common Diagnostic Pitfalls in Thyroid Cytopathology

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Abstract

The 2007 National Cancer Institute State of the Science Conference proposed a category of follicular lesion of undetermined significance (FLUS) or atypia of unknown significance (AUS) for lesions that are characterized by too great a degree of architectural or cytologic atypia for definitive assignment to the benign category but insufficient findings for a diagnosis of follicular neoplasm or suspicious for carcinoma. Studies have shown that routinely subclassifying lesions in the FLUS category into two help to better stratify these cases for management, and uniform criteria have been defined for both subcategories. The first subcategory is for cases that demonstrate low cellularity as well as a predominantly microfollicular pattern and no or minimal colloid. These features elicit concern for a follicular neoplasm. The second subcategory is used for cases that show nuclear atypia, which elicit concern for a papillary carcinoma.

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Authors and Affiliations

  1. Department of Pathology, Yale University School of Medicine, New Haven, CT, USA

    Adebowale J. Adeniran

  2. Department of Pathology, Mount Sinai Health System, New York, NY, USA

    David Chhieng

Authors
  1. Adebowale J. Adeniran
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  2. David Chhieng
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© 2016 Springer International Publishing Switzerland

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Adeniran, A.J., Chhieng, D. (2016). Usefulness of Subclassification of Follicular Lesion of Undetermined Significance. In: Common Diagnostic Pitfalls in Thyroid Cytopathology. Springer, Cham. https://doi.org/10.1007/978-3-319-31602-4_2

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  • DOI: https://doi.org/10.1007/978-3-319-31602-4_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-31600-0

  • Online ISBN: 978-3-319-31602-4

  • eBook Packages: MedicineMedicine (R0)

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