Abstract
The 2007 National Cancer Institute State of the Science Conference proposed a category of follicular lesion of undetermined significance (FLUS) or atypia of unknown significance (AUS) for lesions that are characterized by too great a degree of architectural or cytologic atypia for definitive assignment to the benign category but insufficient findings for a diagnosis of follicular neoplasm or suspicious for carcinoma. Studies have shown that routinely subclassifying lesions in the FLUS category into two help to better stratify these cases for management, and uniform criteria have been defined for both subcategories. The first subcategory is for cases that demonstrate low cellularity as well as a predominantly microfollicular pattern and no or minimal colloid. These features elicit concern for a follicular neoplasm. The second subcategory is used for cases that show nuclear atypia, which elicit concern for a papillary carcinoma.
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Adeniran, A.J., Chhieng, D. (2016). Usefulness of Subclassification of Follicular Lesion of Undetermined Significance. In: Common Diagnostic Pitfalls in Thyroid Cytopathology. Springer, Cham. https://doi.org/10.1007/978-3-319-31602-4_2
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