Skip to main content

Ejaculatory Disorders

  • 969 Accesses

Part of the Contemporary Endocrinology book series (COE)

Abstract

Ejaculation is a highly integrated process that involves both the sympathetic and parasympathetic neural pathways. Numerous studies reveal that ejaculatory dysfunction is a common disorder and the source of significant bother for many of those affected. Ejaculatory dysfunction comprises several different, more specific abnormalities including: premature ejaculation, inhibited ejaculation (consisting of delayed and absent ejaculation), and painful ejaculation. The evaluation of affected patients should include a comprehensive medical history, physical examination, and laboratory testing. Numerous therapeutic options are available to treat ejaculatory disorders, with many of these leading to marked improvement in patients’ symptoms and associated bother.

Keywords

  • Desire
  • Arousal
  • Orgasm
  • Resolution
  • Emission
  • Expulsion
  • Premature ejaculation
  • Inhibited ejaculation
  • Delayed ejaculation
  • Painful ejaculation
  • Anejaculation

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-319-31587-4_25
  • Chapter length: 25 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   84.99
Price excludes VAT (USA)
  • ISBN: 978-3-319-31587-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   109.99
Price excludes VAT (USA)
Hardcover Book
USD   159.99
Price excludes VAT (USA)

References

  1. Masters WH, Johnson VE. Human sexual response. Little, Brown and Company: Boston, MA; 1966.

    Google Scholar 

  2. Rosen R, Altwein J, Boyle P, Kirby RS, Lukacs B, Meuleman E, et al. Lower urinary tract symptoms and male sexual dysfunction: the multinational survey of the aging male (MSAM-7). Eur Urol. 2003;44(6):637–49.

    PubMed  CrossRef  Google Scholar 

  3. Giuliano F, Clement P. Physiology of ejaculation: emphasis on serotonergic control. Eur Urol. 2005;48(3):408–17.

    PubMed  CrossRef  Google Scholar 

  4. Newman HF, Reiss H, Northup JD. Physical basis of emission, ejaculation, and orgasm in the male. Urology. 1982;19(4):341–50.

    CAS  PubMed  CrossRef  Google Scholar 

  5. Barnas JL, Pierpaoli S, Ladd P, Valenzuela R, Aviv N, Parker M, et al. The prevalence and nature of orgasmic dysfunction after radical prostatectomy. BJU Int. 2004;94(4):603–5.

    PubMed  CrossRef  Google Scholar 

  6. Schlegel PN, Walsh PC. Neuroanatomical approach to radical cystoprostatectomy with preservation of sexual function. J Urol. 1987;138(6):1402–6.

    CAS  PubMed  Google Scholar 

  7. Keast J. Autonomic Ganglia. In: McLachlan E, editor. Pelvic ganglia. Luxemburg: Harwood Academin; 1995. p. 445–79.

    Google Scholar 

  8. Ver Voort SM. Ejaculatory stimulation in spinal-cord injured men. Urology. 1987;29(3):282–9.

    CAS  PubMed  CrossRef  Google Scholar 

  9. Amelar RD, Hotchkiss RS. The split ejaculate: its use in the management of male infertility. Fertil Steril. 1965;16:46–60.

    CAS  PubMed  CrossRef  Google Scholar 

  10. McKenna KE, Chung SK, McVary KT. A model for the study of sexual function in anesthetized male and female rats. Am J Physiol. 1991;261(5 Pt 2):R1276–85.

    CAS  PubMed  Google Scholar 

  11. Truitt WA, Coolen LM. Identification of a potential ejaculation generator in the spinal cord. Science. 2002;297(5586):1566–9.

    CAS  PubMed  CrossRef  Google Scholar 

  12. Allard J, Truitt WA, McKenna KE, Coolen LM. Spinal cord control of ejaculation. World J Urol. 2005;23(2):119–26.

    PubMed  CrossRef  Google Scholar 

  13. Coolen LM, Allard J, Truitt WA, McKenna KE. Central regulation of ejaculation. Physiol Behav. 2004;83(2):203–15.

    CAS  PubMed  CrossRef  Google Scholar 

  14. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: prevalence and predictors. JAMA. 1999;281(6):537–44.

    CAS  PubMed  CrossRef  Google Scholar 

  15. Dunn KM, Croft PR, Hackett GI. Association of sexual problems with social, psychological, and physical problems in men and women: a cross sectional population survey. J Epidemiol Community Health. 1999;53(3):144–8.

    CAS  PubMed  PubMed Central  CrossRef  Google Scholar 

  16. Masters WH, Johnson VE. Human sexual inadequacy. London: Churchill; 1970. p. xi–467.

    Google Scholar 

  17. Waldinger MD, Schweitzer DH. Changing paradigms from a historical DSM-III and DSM-IV view toward an evidence-based definition of premature ejaculation. Part I – validity of DSM-IV-TR. J Sex Med. 2006;3(4):682–92.

    PubMed  CrossRef  Google Scholar 

  18. Symonds T, Perelman M, Althof S, Giuliano F, Martin M, Abraham L, et al. Further evidence of the reliability and validity of the premature ejaculation diagnostic tool. Int J Impot Res. 2007;19(5):521–5.

    CAS  PubMed  CrossRef  Google Scholar 

  19. Waldinger MD, Hengeveld MW, Zwinderman AH. Paroxetine treatment of premature ejaculation: a double-blind, randomized, placebo-controlled study. Am J Psychiatry. 1994;151(9):1377–9.

    CAS  PubMed  CrossRef  Google Scholar 

  20. Patrick DL, Althof SE, Pryor JL, Rosen R, Rowland DL, Ho KF, et al. Premature ejaculation: an observational study of men and their partners. J Sex Med. 2005;2(3):358–67.

    PubMed  CrossRef  Google Scholar 

  21. Rowland DL, Cooper SE, Schneider M. Defining premature ejaculation for experimental and clinical investigations. Arch Sex Behav. 2001;30(3):235–53.

    CAS  PubMed  CrossRef  Google Scholar 

  22. Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH. Proposal for a definition of lifelong premature ejaculation based on epidemiological stopwatch data. J Sex Med. 2005;2(4):498–507.

    PubMed  CrossRef  Google Scholar 

  23. Dinsmore WW, Ralph DJ, Kell P, Wylie KR, Dean JP, Novak C, et al. Evaluation of the sexual assessment monitor, a diagnostic device used to electronically quantify ejaculatory latency time: findings from three studies. BJU Int. 2006;98(3):613–8.

    PubMed  CrossRef  Google Scholar 

  24. Lue TF, Giuliano F, Montorsi F, Rosen RC, Andersson KE, Althof S, et al. Summary of the recommendations on sexual dysfunctions in men. J Sex Med. 2004;1(1):6–23.

    PubMed  CrossRef  Google Scholar 

  25. Sharlip ID. Guidelines for the diagnosis and management of premature ejaculation. J Sex Med. 2006;3 Suppl 4:309–17.

    CAS  PubMed  CrossRef  Google Scholar 

  26. Montague DK, Jarow J, Broderick GA, Dmochowski RR, Heaton JP, Lue TF, et al. AUA guideline on the pharmacologic management of premature ejaculation. J Urol. 2004;172(1):290–4.

    PubMed  CrossRef  Google Scholar 

  27. Colpi GM, Fanciullacci F, Beretta G, Negri L, Zanollo A. Evoked sacral potentials in subjects with true premature ejaculation. Andrologia. 1986;18(6):583–6.

    CAS  CrossRef  PubMed  Google Scholar 

  28. Fanciullacci F, Colpi GM, Beretta G, Zanollo A. Cortical evoked potentials in subjects with true premature ejaculation. Andrologia. 1988;20(4):326–30.

    CAS  PubMed  CrossRef  Google Scholar 

  29. Shull GR, Sprenkle DH. Retarded ejaculation reconceptualization and implications for treatment. J Sex Marital Ther. 1980;6(4):234–46.

    CAS  PubMed  CrossRef  Google Scholar 

  30. Semans JH. Premature ejaculation: a new approach. South Med J. 1956;49(4):353–8.

    CAS  PubMed  CrossRef  Google Scholar 

  31. De Amicis LA, Goldberg DC, LoPiccolo J, Friedman J, Davies L. Clinical follow-up of couples treated for sexual dysfunction. Arch Sex Behav. 1985;14(6):467–89.

    PubMed  CrossRef  Google Scholar 

  32. Busato W, Galindo CC. Topical anaesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study. BJU Int. 2004;93(7):1018–21.

    CAS  PubMed  CrossRef  Google Scholar 

  33. Henry R, Morales A. Topical lidocaine-prilocaine spray for the treatment of premature ejaculation: a proof of concept study. Int J Impot Res. 2003;15(4):277–81.

    CAS  PubMed  CrossRef  Google Scholar 

  34. Hull EM, Lumley LA, Matuszewich L, Dominguez J, Moses J, Lorrain DS. The roles of nitric oxide in sexual function of male rats. Neuropharmacology. 1994;33(11):1499–504.

    CAS  PubMed  CrossRef  Google Scholar 

  35. McMahon CG, Stuckey BG, Andersen M, Purvis K, Koppiker N, Haughie S, et al. Efficacy of sildenafil citrate (Viagra) in men with premature ejaculation. J Sex Med. 2005;2(3):368–75.

    CAS  PubMed  CrossRef  Google Scholar 

  36. Pryor JL, Althof SE, Steidle C, Rosen RC, Hellstrom WJ, Shabsigh R, et al. Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials. Lancet. 2006;368(9539):929–37.

    CAS  PubMed  CrossRef  Google Scholar 

  37. Safarinejad MR. Safety and efficacy of dapoxetine in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study. Neuropsychopharmacology. 2008;33(6):1259–65.

    CAS  PubMed  CrossRef  Google Scholar 

  38. Waldinger MD, Schweitzer DH. Premature ejaculation and pharmaceutical company-based medicine: the dapoxetine case. J Sex Med. 2008;5(4):966–97.

    CAS  PubMed  CrossRef  Google Scholar 

  39. Kim JJ, Kwak TI, Jeon BG, Cheon J, Moon DG. Effects of glans penis augmentation using hyaluronic acid gel for premature ejaculation. Int J Impot Res. 2004;16(6):547–51.

    CAS  CrossRef  PubMed  Google Scholar 

  40. Lue TF, Basson R, Rosen R, Giuliano F, Khoury S, Montorsi F. Sexual medicine: sexual dysfunctions in men and women. In: McMahon CG, Abdo C, Hull EM, Incrocci L, Levine L, Perelman MA, et al., editors. Plymouth, MA: Health Publications; 2004. p. 409–68.

    Google Scholar 

  41. American Psychiatric Association. Diagnostic criteria from DSM-IV-TR. Washington, DC: American Psychiatric Association; 2000. p. 370, xii.

    Google Scholar 

  42. McMahon CG, Jannini E, Waldinger M, Rowland D. Standard operating procedures in the disorders of orgasm and ejaculation. J Sex Med. 2013;10(1):204–29.

    PubMed  CrossRef  Google Scholar 

  43. Kinsey AC, Pomeroy WB, Martin CE, New York Academy of Medicine. Sexual behavior in the human male. Philadelphia, PA: WB Saunders Co; 1948. p. 804, xv.

    Google Scholar 

  44. Rowland DL, Keeney C, Slob AK. Sexual response in men with inhibited or retarded ejaculation. Int J Impot Res. 2004;16(3):270–4.

    CAS  PubMed  CrossRef  Google Scholar 

  45. Nathan SG. The epidemiology of the DSM-III psychosexual dysfunctions. J Sex Marital Ther. 1986;12(4):267–81.

    CAS  PubMed  CrossRef  Google Scholar 

  46. Richardson D, Nalabanda A, Goldmeier D. Retarded ejaculation – a review. Int J STD AIDS. 2006;17(3):143–50.

    PubMed  CrossRef  Google Scholar 

  47. Spector IP, Carey MP. Incidence and prevalence of the sexual dysfunctions: a critical review of the empirical literature. Arch Sex Behav. 1990;19(4):389–408.

    CAS  PubMed  CrossRef  Google Scholar 

  48. Nazareth I, Boynton P, King M. Problems with sexual function in people attending London general practitioners: cross sectional study. BMJ. 2003;327(7412):423.

    PubMed  PubMed Central  CrossRef  Google Scholar 

  49. McCabe MP, Connaughton C. Psychosocial factors associated with male sexual difficulties. J Sex Res. 2014;51(1):31–42.

    PubMed  CrossRef  Google Scholar 

  50. Mulhall JP, Hsiao W. Men’s sexual health and fertility: a clinician’s guide. Nelson CJ, Brock D, Dean RC, editors. New York, NY: Springer; 2014.

    CrossRef  Google Scholar 

  51. Jannini EA, Simonelli C, Lenzi A. Sexological approach to ejaculatory dysfunction. Int J Androl. 2002;25(6):317–23.

    CAS  PubMed  CrossRef  Google Scholar 

  52. Jannini EA, Simonelli C, Lenzi A. Disorders of ejaculation. J Endocrinol Invest. 2002;25(11):1006–19.

    CAS  PubMed  CrossRef  Google Scholar 

  53. Montorsi F, Adaikan G, Becher E, Giuliano F, Khoury S, Lue TF, et al. Summary of the recommendations on sexual dysfunctions in men. J Sex Med. 2010;7(11):3572–88.

    PubMed  CrossRef  Google Scholar 

  54. Abdel-Hamid IA, el Saleh S. Primary lifelong delayed ejaculation: characteristics and response to bupropion. J Sex Med. 2011;8(6):1772–9.

    PubMed  CrossRef  Google Scholar 

  55. Perelman MA, Rowland DL. Retarded ejaculation. World J Urol. 2006;24(6):645–52.

    PubMed  CrossRef  Google Scholar 

  56. Perelman MA. Delayed ejaculation. In: Binik YM, Hall KSK, editors. Principles and practice of sex therapy. 5th ed. New York, NY: The Guilford Press; 2014. p. 138–55.

    Google Scholar 

  57. Waldinger MD. Toward evidence-based genetic research on lifelong premature ejaculation: a critical evaluation of methodology. Korean J Urol. 2011;52(1):1–8.

    PubMed  PubMed Central  CrossRef  Google Scholar 

  58. Gregoire A. ABC of sexual health: assessing and managing male sexual problems. BMJ. 1999;318(7179):315–7.

    CAS  PubMed  PubMed Central  CrossRef  Google Scholar 

  59. McMahon CG, Abdo C, Incrocci L, Perelman M, Rowland D, Waldinger M, et al. Disorders of orgasm and ejaculation in men. J Sex Med. 2004;1(1):58–65.

    PubMed  CrossRef  Google Scholar 

  60. Edwards AE, Husted JR. Penile sensitivity, age, and sexual behavior. J Clin Psychol. 1976;32(3):697–700.

    CAS  PubMed  CrossRef  Google Scholar 

  61. Waldinger MD, Quinn P, Dilleen M, Mundayat R, Schweitzer DH, Boolell M. A multinational population survey of intravaginal ejaculation latency time. J Sex Med. 2005;2(4):492–7.

    PubMed  CrossRef  Google Scholar 

  62. Latini DM, Penson DF, Wallace KL, Lubeck DP, Lue TF. Clinical and psychosocial characteristics of men with erectile dysfunction: baseline data from ExCEED. J Sex Med. 2006;3(6):1059–67.

    PubMed  CrossRef  Google Scholar 

  63. Gierveld Jde J, van Groenou MB, Hoogendoorn AW, Smit JH. Quality of marriages in later life and emotional and social loneliness. J Gerontol B Psychol Sci Soc Sci. 2009;64(4):497–506.

    PubMed  CrossRef  Google Scholar 

  64. DasGupta R, Fowler CJ. Sexual and urological dysfunction in multiple sclerosis: better understanding and improved therapies. Curr Opin Neurol. 2002;15(3):271–8.

    PubMed  CrossRef  Google Scholar 

  65. Enzlin P, Mathieu C, Van Den Bruel A, Vanderschueren D, Demyttenaere K. Prevalence and predictors of sexual dysfunction in patients with type 1 diabetes. Diabetes Care. 2003;26(2):409–14.

    PubMed  CrossRef  Google Scholar 

  66. Minderhoud JM, Leemhuis JG, Kremer J, Laban E, Smits PM. Sexual disturbances arising from multiple sclerosis. Acta Neurol Scand. 1984;70(4):299–306.

    CAS  PubMed  CrossRef  Google Scholar 

  67. Comarr AE. Sexual function among patients with spinal cord injury. Urol Int. 1970;25(2):134–68.

    CAS  PubMed  CrossRef  Google Scholar 

  68. Xia JD, Han YF, Pan F, Zhou LH, Chen Y, Dai YT. Clinical characteristics and penile afferent neuronal function in patients with primary delayed ejaculation. Andrology. 2013;1(5):787–92.

    PubMed  CrossRef  Google Scholar 

  69. Fletcher MS, Herzberg Z, Pryor JP. The aetiology and investigation of haemospermia. Br J Urol. 1981;53(6):669–71.

    CAS  PubMed  CrossRef  Google Scholar 

  70. Corona G, Jannini EA, Mannucci E, Fisher AD, Lotti F, Petrone L, et al. Different testosterone levels are associated with ejaculatory dysfunction. J Sex Med. 2008;5(8):1991–8.

    CAS  PubMed  CrossRef  Google Scholar 

  71. Corona G, Jannini EA, Vignozzi L, Rastrelli G, Maggi M. The hormonal control of ejaculation. Nat Rev Urol. 2012;9(9):508–19.

    CAS  PubMed  CrossRef  Google Scholar 

  72. Paduch D, Polzer P, Ni X, Basaria S. Effects of testosterone solution 2 % for the treatment of ejauclatory dysfunction in androgen-deficient men. 20th Annual fall scientific meeting of SMSNA, 20–23 Nov 2014 Program Book. 2014(Abtract 003):53.

    Google Scholar 

  73. Paduch D, Polzer P, Morgentaler A, Althof SE, Ni X, Patel A, et al. Prevalence of ejaculatory dysfunction as a function of testosterone. 20th Annual fall scientific meeting of SMSNA, 20–23 Nov 2014 Program Book. 2014(Abstract 004):52.

    Google Scholar 

  74. Paduch D, Polzer P, Ni X, Basaria S. Testosterone replacement in androgen-deficient men with ejaculatory dysfunction: a randomized controlled trial. J Clin Endocrinol Metab. 2015;100(8):2956–62.

    CAS  PubMed  CrossRef  Google Scholar 

  75. Carani C, Isidori AM, Granata A, Carosa E, Maggi M, Lenzi A, et al. Multicenter study on the prevalence of sexual symptoms in male hypo- and hyperthyroid patients. J Clin Endocrinol Metab. 2005;90(12):6472–9.

    CAS  PubMed  CrossRef  Google Scholar 

  76. Corona G, Petrone L, Paggi F, Lotti F, Boddi V, Fisher A, et al. Sexual dysfunction in subjects with Klinefelter’s syndrome. Int J Androl. 2010;33(4):574–80.

    CAS  PubMed  Google Scholar 

  77. Fitzgerald P, Dinan TG. Prolactin and dopamine: what is the connection? A review article. J Psychopharmacol. 2008;22(2 Suppl):12–9.

    PubMed  CrossRef  Google Scholar 

  78. Kruger TH, Hartmann U, Schedlowski M. Prolactinergic and dopaminergic mechanisms underlying sexual arousal and orgasm in humans. World J Urol. 2005;23(2):130–8.

    PubMed  CrossRef  CAS  Google Scholar 

  79. Corona G, Ricca V, Bandini E, Mannucci E, Lotti F, Boddi V, et al. Selective serotonin reuptake inhibitor-induced sexual dysfunction. J Sex Med. 2009;6(5):1259–69.

    CAS  PubMed  CrossRef  Google Scholar 

  80. Kiev A, Feiger A. A double-blind comparison of fluvoxamine and paroxetine in the treatment of depressed outpatients. J Clin Psychiatry. 1997;58(4):146–52.

    CAS  PubMed  CrossRef  Google Scholar 

  81. Keller R, Mongini F. Switch to quetiapine in antipsychotic agent-related hyperprolactinemia. Neurol Sci. 2002;23(5):233–5.

    CAS  PubMed  CrossRef  Google Scholar 

  82. Rowland D, van Diest S, Incrocci L, Slob AK. Psychosexual factors that differentiate men with inhibited ejaculation from men with no dysfunction or another sexual dysfunction. J Sex Med. 2005;2(3):383–9.

    PubMed  CrossRef  Google Scholar 

  83. Althof SE. Psychological interventions for delayed ejaculation/orgasm. Int J Impot Res. 2012;24(4):131–6.

    CAS  PubMed  CrossRef  Google Scholar 

  84. Fathy A, Shamloul R, AbdelRahim A, Zeidan A, El-Dakhly R, Ghanem H. Experience with Tube (Promedon) malleable penile implant. Urol Int. 2007;79(3):244–7.

    PubMed  CrossRef  Google Scholar 

  85. Shaeer O. The global online sexuality survey (GOSS): the United States of America in 2011 Chapter III – premature ejaculation among English-speaking male Internet users. J Sex Med. 2013;10(7):1882–8.

    PubMed  CrossRef  Google Scholar 

  86. Bronner G, Ben-Zion IZ. Unusual masturbatory practice as an etiological factor in the diagnosis and treatment of sexual dysfunction in young men. J Sex Med. 2014;11(7):1798–806.

    PubMed  CrossRef  Google Scholar 

  87. Perelman M. Idiosyncratic masturbation patterns: a key unexplored variable in the treatment of retarded ejaculation by the practicing urologist. J Urol. 2005;173:340. Abstract 1254.

    CrossRef  Google Scholar 

  88. Sank LI. Traumatic masturbatory syndrome. J Sex Marital Ther. 1998;24(1):37–42.

    CAS  PubMed  CrossRef  Google Scholar 

  89. Rothbart D. He’s just not that into anyone (cover story). New York, 2 Jul 2011, p. 83–8.

    Google Scholar 

  90. Carvalheira A, Traeen B, Stulhofer A. Masturbation and pornography use among coupled heterosexual men with decreased sexual desire: how many roles of masturbation? J Sex Marital Ther. 2014;1–10.

    Google Scholar 

  91. Rowland D, McMahon CG, Abdo C, Chen J, Jannini E, Waldinger MD, et al. Disorders of orgasm and ejaculation in men. J Sex Med. 2010;7(4 Pt 2):1668–86.

    PubMed  CrossRef  Google Scholar 

  92. Teloken P, Nelson C, Mullhall J. Outcomes with medical treatment of secondary delayed orgasm proposal of a clinical care pathway. J Urol. 2012;187(4 Suppl 1496):606.

    CrossRef  Google Scholar 

  93. Butcher M, Sadowski D, Botchway A, Welliver C, Kohler T. Delayed ejaculation remains a recalcitrant condition: results of a SMSNA survey. 20th Annual fall scientific meeting of SMSNA, 20–23 Nov 2014. Program Book. 2014(Abstract 041):70.

    Google Scholar 

  94. Porst H, Buvat J, Standards Committee of the International Society for Sexual Medicine. Standard practice in sexual medicine. McMahon CG, Waldinger M, Rowland D, Assalian P, Kim YC, Bechara A, et al., editors. Malden, Mass.; Oxford: Blackwell Pub. 2006. p. 188–209.

    Google Scholar 

  95. Aukst-Margetic B, Margetic B. An open-label series using loratadine for the treatment of sexual dysfunction associated with selective serotonin reuptake inhibitors. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(5):754–6.

    CAS  PubMed  CrossRef  Google Scholar 

  96. Shin D, Spitz A. The evaluation and treatment of delayed ejaculation. Sex Med Rev. 2014;2(3-4):121–33.

    CrossRef  Google Scholar 

  97. Menendez Abraham E, Moran Viesca P, Velasco Plaza A, Marin B. Modifications of the sexual activity in male rats following administration of antiserotoninergic drugs. Behav Brain Res. 1988;30(3):251–8.

    CAS  PubMed  CrossRef  Google Scholar 

  98. Ashton AK, Hamer R, Rosen RC. Serotonin reuptake inhibitor-induced sexual dysfunction and its treatment: a large-scale retrospective study of 596 psychiatric outpatients. J Sex Marital Ther. 1997;23(3):165–75.

    CrossRef  Google Scholar 

  99. Lauerma H. Successful treatment of citalopram-induced anorgasmia by cyproheptadine. Acta Psychiatr Scand. 1996;93(1):69–70.

    CAS  PubMed  CrossRef  Google Scholar 

  100. Steele TE, Howell EF. Cyproheptadine for imipramine-induced anorgasmia. J Clin Psychopharmacol. 1986;6(5):326–7.

    CAS  PubMed  CrossRef  Google Scholar 

  101. Sovner R. Treatment of tricyclic antidepressant-induced orgasmic inhibition with cyproheptadine. J Clin Psychopharmacol. 1984;4(3):169.

    CAS  PubMed  CrossRef  Google Scholar 

  102. McCormick S, Olin J, Brotman AW. Reversal of fluoxetine-induced anorgasmia by cyproheptadine in two patients. J Clin Psychiatry. 1990;51(9):383–4.

    CAS  PubMed  Google Scholar 

  103. DeBattista C, Solvason B, Poirier J, Kendrick E, Loraas E. A placebo-controlled, randomized, double-blind study of adjunctive bupropion sustained release in the treatment of SSRI-induced sexual dysfunction. J Clin Psychiatry. 2005;66(7):844–8.

    CAS  PubMed  CrossRef  Google Scholar 

  104. Safarinejad MR. Midodrine for the treatment of organic anejaculation but not spinal cord injury: a prospective randomized placebo-controlled double-blind clinical study. Int J Impot Res. 2009;21(4):213–20.

    CAS  PubMed  CrossRef  Google Scholar 

  105. Ferraz MM, Fontanella JC, Damasceno F, Silva de Almeida OM, Ferraz MR. Chronic amantadine treatment enhances the sexual behaviour of male rats. Pharmacol Biochem Behav. 2007;86(4):616–21.

    CAS  PubMed  CrossRef  Google Scholar 

  106. Balon R. Intermittent amantadine for fluoxetine-induced anorgasmia. J Sex Marital Ther. 1996;22(4):290–2.

    CAS  PubMed  CrossRef  Google Scholar 

  107. Wittstock M, Benecke R, Dressler D. Cabergoline can increase penile erections and libido. Neurology. 2002;58(5):831.

    CrossRef  PubMed  Google Scholar 

  108. Kruger TH, Haake P, Haverkamp J, Kramer M, Exton MS, Saller B, et al. Effects of acute prolactin manipulation on sexual drive and function in males. J Endocrinol. 2003;179(3):357–65.

    CAS  PubMed  CrossRef  Google Scholar 

  109. Veening JG, de Jong TR, Waldinger MD, Korte SM, Olivier B. The role of oxytocin in male and female reproductive behavior. Eur J Pharmacol. 2015;753:209–28.

    CAS  PubMed  CrossRef  Google Scholar 

  110. Labbate LA, Grimes JB, Hines A, Pollack MH. Bupropion treatment of serotonin reuptake antidepressant-associated sexual dysfunction. Ann Clin Psychiatry. 1997;9(4):241–5.

    CAS  PubMed  CrossRef  Google Scholar 

  111. Ashton AK, Rosen RC. Bupropion as an antidote for serotonin reuptake inhibitor-induced sexual dysfunction. J Clin Psychiatry. 1998;59(3):112–5.

    CAS  PubMed  CrossRef  Google Scholar 

  112. Landen M, Eriksson E, Agren H, Fahlen T. Effect of buspirone on sexual dysfunction in depressed patients treated with selective serotonin reuptake inhibitors. J Clin Psychopharmacol. 1999;19(3):268–71.

    CAS  PubMed  CrossRef  Google Scholar 

  113. Carro-Juareza M, Rodriguez-Manzo G. Yohimbine reverses the exhaustion of the coital reflex in spinal male rats. Behav Brain Res. 2003;141(1):43–50.

    CAS  PubMed  CrossRef  Google Scholar 

  114. Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry. 1992;53(4):119–22.

    CAS  PubMed  Google Scholar 

  115. Adeniyi AA, Brindley GS, Pryor JP, Ralph DJ. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl. 2007;9(3):403–7.

    CAS  PubMed  CrossRef  Google Scholar 

  116. Melnyk J, Marcone M. Aphrodisiacs from plant and animal sources—a review of current scientific literature. Food Res Int. 2011;44:840–50.

    CrossRef  Google Scholar 

  117. Segraves RT. Reversal by bethanechol of imipramine-induced ejaculatory dysfunction. Am J Psychiatry. 1987;144(9):1243–4.

    CAS  PubMed  Google Scholar 

  118. Yager J. Bethanechol chloride can reverse erectile and ejaculatory dysfunction induced by tricyclic antidepressants and mazindol: case report. J Clin Psychiatry. 1986;47(4):210–1.

    CAS  PubMed  Google Scholar 

  119. Stafford SA, Coote JH. Activation of D2-like receptors induces sympathetic climactic-like responses in male and female anaesthetised rats. Br J Pharmacol. 2006;148(4):510–6.

    CAS  PubMed  PubMed Central  CrossRef  Google Scholar 

  120. Lu W, Jiang W, Chen J, Yin M, Wang Z, Jiang X. Modulation of brain delivery and copulation by intranasal apomorphine hydrochloride. Int J Pharm. 2008;349(1-2):196–205.

    CAS  PubMed  CrossRef  Google Scholar 

  121. Kendirci M, Hellstrom WJ. Intranasal apomorphine. Nastech Pharmaceutical. Investig Drug J. 2004;7(5):483–8.

    CAS  Google Scholar 

  122. Bartlik BD, Kaplan P, Kaplan HS. Psychostimulants apparently reverse sexual dysfunction secondary to selective serotonin re-uptake inhibitors. J Sex Marital Ther. 1995;21(4):264–71.

    CAS  PubMed  CrossRef  Google Scholar 

  123. McMahon CG. Management of ejaculatory dysfunction. Intern Med J. 2014;44(2):124–31.

    CAS  PubMed  CrossRef  Google Scholar 

  124. Haberfellner EM. Sexual dysfunction caused by reboxetine. Pharmacopsychiatry. 2002;35(2):77–8.

    CAS  PubMed  CrossRef  Google Scholar 

  125. O'Flynn R, Michael A. Reboxetine-induced spontaneous ejaculation. Br J Psychiatry. 2000;177:567–8.

    PubMed  CrossRef  Google Scholar 

  126. Sivrioglu EY, Topaloglu VC, Sarandol A, Akkaya C, Eker SS, Kirli S. Reboxetine induced erectile dysfunction and spontaneous ejaculation during defecation and micturition. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(2):548–50.

    CAS  PubMed  CrossRef  Google Scholar 

  127. Taylor MJ. Strategies for managing antidepressant-induced sexual dysfunction: a review. Curr Psychiatry Rep. 2006;8(6):431–6.

    PubMed  CrossRef  Google Scholar 

  128. Schweitzer I, Maguire K, Ng C. Sexual side-effects of contemporary antidepressants: review. Aust N Z J Psychiatry. 2009;43(9):795–808.

    PubMed  CrossRef  Google Scholar 

  129. Sonksen J, Ohl DA, Wedemeyer G. Sphincteric events during penile vibratory ejaculation and electroejaculation in men with spinal cord injuries. J Urol. 2001;165(2):426–9.

    CAS  PubMed  CrossRef  Google Scholar 

  130. Nelson CJ, Ahmed A, Valenzuela R, Parker M, Mulhall JP. Assessment of penile vibratory stimulation as a management strategy in men with secondary retarded orgasm. Urology. 2007;69(3):552–5. discussion 5–6.

    PubMed  PubMed Central  CrossRef  Google Scholar 

  131. Previnaire JG, Lecourt G, Soler JM, Denys P. Sexual disorders in men with multiple sclerosis: evaluation and management. Ann Phys Rehabil Med. 2014;57(5):329–36.

    CAS  PubMed  CrossRef  Google Scholar 

  132. Lieblum S, Rosen R. Principles and practice of sex therapy. 2nd ed. New York, NY: Guilford Press; 2000.

    Google Scholar 

  133. Perelman MA. A new combination treatment for premature ejaculation: a sex therapist's perspective. J Sex Med. 2006;3(6):1004–12.

    PubMed  CrossRef  Google Scholar 

  134. Rust J, Golombok S, Collier J. Marital problems and sexual dysfunction: how are they related? Br J Psychiatry. 1988;152:629–31.

    CAS  PubMed  CrossRef  Google Scholar 

  135. Snyder DK, Berg P. Determinants of sexual dissatisfaction in sexually distressed couples. Arch Sex Behav. 1983;12(3):237–46.

    CAS  PubMed  CrossRef  Google Scholar 

  136. Barnas J, Parker M, Guhring P, Mulhall JP. The utility of tamsulosin in the management of orgasm-associated pain: a pilot analysis. Eur Urol. 2005;47(3):361–5. discussion 5.

    CAS  PubMed  CrossRef  Google Scholar 

  137. Johnson CW, Bingham JB, Goluboff ET, Fisch H. Transurethral resection of the ejaculatory ducts for treating ejaculatory symptoms. BJU Int. 2005;95(1):117–9.

    PubMed  CrossRef  Google Scholar 

  138. Antolak S, Hough D, Maus T. Chronic pelvic pain syndrome (pudendal neuralgia or category IIIB chronic prostatitis). Rochester, MN: Mayo Clinic; 2002.

    Google Scholar 

  139. Kulik FA, Wilbur R. Case report of painful ejaculation as a side effect of amoxapine. Am J Psychiatry. 1982;139(2):234–5.

    CAS  PubMed  CrossRef  Google Scholar 

  140. Aizenberg D, Zemishlany Z, Hermesh H, Karp L, Weizman A. Painful ejaculation associated with antidepressants in four patients. J Clin Psychiatry. 1991;52(11):461–3.

    CAS  PubMed  Google Scholar 

  141. Hsu JH, Shen WW. Male sexual side effects associated with antidepressants: a descriptive clinical study of 32 patients. Int J Psychiatry Med. 1995;25(2):191–201.

    CAS  PubMed  CrossRef  Google Scholar 

  142. Michael A. Venlafaxine-induced painful ejaculation. Br J Psychiatry. 2000;177:282.

    CAS  PubMed  CrossRef  Google Scholar 

  143. Demyttenaere K, Huygens R. Painful ejaculation and urinary hesitancy in association with antidepressant therapy: relief with tamsulosin. Eur Neuropsychopharmacol. 2002;12(4):337–41.

    CAS  PubMed  CrossRef  Google Scholar 

  144. Roberts RO, Jacobson DJ, Girman CJ, Rhodes T, Lieber MM, Jacobsen SJ. Prevalence of prostatitis-like symptoms in a community based cohort of older men. J Urol. 2002;168(6):2467–71.

    PubMed  CrossRef  Google Scholar 

  145. Nickel JC, Downey J, Hunter D, Clark J. Prevalence of prostatitis-like symptoms in a population based study using the National Institutes of Health chronic prostatitis symptom index. J Urol. 2001;165(3):842–5.

    CAS  PubMed  CrossRef  Google Scholar 

  146. Litwin MS, McNaughton-Collins M, Fowler Jr FJ, Nickel JC, Calhoun EA, Pontari MA, et al. The National Institutes of Health chronic prostatitis symptom index: development and validation of a new outcome measure. Chronic Prostatitis Collaborative Research Network. J Urol. 1999;162(2):369–75.

    CAS  PubMed  CrossRef  Google Scholar 

  147. Amarenco G, Ismael SS, Bayle B, Denys P, Kerdraon J. Electrophysiological analysis of pudendal neuropathy following traction. Muscle Nerve. 2001;24(1):116–9.

    CAS  PubMed  CrossRef  Google Scholar 

  148. Nadler RB, Rubenstein JN. Laparoscopic excision of a seminal vesicle for the chronic pelvic pain syndrome. J Urol. 2001;166(6):2293–4.

    CAS  PubMed  CrossRef  Google Scholar 

  149. Anderson RU, Wise D, Sawyer T, Chan CA. Sexual dysfunction in men with chronic prostatitis/chronic pelvic pain syndrome: improvement after trigger point release and paradoxical relaxation training. J Urol. 2006;176(4 Pt 1):1534–8. discussion 8–9.

    PubMed  CrossRef  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael J. Butcher DO .

Editor information

Editors and Affiliations

Appendices

Appendices

Appendix 25.1

Algorithm of Disordered Ejaculation in Men. ψ = See Collaboration of Clinician and Sexual Therapist (Appendix 25.2). * = Medications in Table 25.3 can be tried in treatment of Retrograde Ejaculation (see Table 25.3). ^ = If patient on SSRI consider use of SSRI Antidote types of medications (see Table 25.3).  = Medications in Table 3 can be used for Prolactin abnormalities (see Table 25.3).

(Used with permission from Sadowski DJ, Butcher MJ, Kohler TS. Delayed Ejaculation: Medical and Psychological treatments and Algorithms. Current Sexual Health Reports. September 2015; 7(3): 170–179. Created using data in Rowland D, McMahon CG, Abdo C, Chen J, Jannini E, Waldinger MD, et al. Disorders of orgasm and ejaculation in men. The journal of sexual medicine. 2010;7(4 Pt 2):1668–86.)

Appendix 25.2

Collaboration of Clinician and Sexual Therapist (Used with permission from Sadowski DJ, Butcher MJ, Kohler TS. Delayed Ejaculation: Medical and Psychological treatments and Algorithms. Current Sexual Health Reports. September 2015; 7(3): 170–179. Created using data from Perelman, MA. Delayed ejaculation in: Principles and practice of sex therapy. Fifth edition. Binik YM, Hall KSK. (eds). New York, NY: The Guilford Press; 2014. 138–55.)

Rights and permissions

Reprints and Permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Butcher, M.J., Brannigan, R.E. (2016). Ejaculatory Disorders. In: Köhler, T., McVary, K. (eds) Contemporary Treatment of Erectile Dysfunction. Contemporary Endocrinology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-31587-4_25

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-31587-4_25

  • Published:

  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-31585-0

  • Online ISBN: 978-3-319-31587-4

  • eBook Packages: MedicineMedicine (R0)