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Similarities and Differences in the Electrocardiographic and Clinical Features Between Early Repolarization Syndrome and Brugada Syndrome

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J Wave Syndromes

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Abstract

Both Brugada syndrome (BrS) and early repolarization syndrome (ERS) are associated with ST-segment and/or J-point elevation and sudden cardiac death due to ventricular fibrillation. There exist several similarities between BrS and ERS in the genetic, clinical, electrocardiographic, and electrophysiological characteristics, such as causative genes, male dominance, late adulthood onset, pause-dependent augmentation of J-point elevation, and response to drugs. However, the two clinical entities also have certain differences. In this chapter, the currently available evidence for similarities and differences between BrS and ERS in these features will be presented and discussed.

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Grant

Dr. W Shimizu was supported in part by the Research Grant for the Cardiovascular Diseases (H24-033, H26-040, H27-032) from the Ministry of Health, Labour and Welfare, Japan, and a Nippon Medical School Grant-in-Aid for Medical Research.

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  1. Department of Cardiovascular Medicine, Graduate School of Medicine, Nippon Medical School, 1-1-5, Sendagi Bunkyo-ku, Tokyo, 113-8603, Japan

    Wataru Shimizu MD, PhD

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  1. Wataru Shimizu MD, PhD
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Correspondence to Wataru Shimizu MD, PhD .

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  1. Cardiovascular Research, Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, USA

    Charles Antzelevitch

  2. Lankenau Institute for Medical Research, Lankenau Medical Center, Wynnewood, Pennsylvania, USA

    Gan-Xin Yan

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Shimizu, W. (2016). Similarities and Differences in the Electrocardiographic and Clinical Features Between Early Repolarization Syndrome and Brugada Syndrome. In: Antzelevitch, C., Yan, GX. (eds) J Wave Syndromes. Springer, Cham. https://doi.org/10.1007/978-3-319-31578-2_11

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