Abstract
In anatomic pathology, cholestasis refers to microscopically visible bile in a section of liver tissue (Fig. 6.1). It can be present anywhere along the biliary tree, from hepatocellular canaliculi to small or large bile ducts. In many instances, cholestasis is a relatively minor component of the pathologic changes seen in a specimen, but in other cases, it may be the only pathologic change (this is known as “bland cholestasis”). Cholestasis may result from a disease of the biliary tree (as in primary biliary cirrhosis), may occur secondary to defects in bile synthesis and transport (as in progressive familial intrahepatic cholestasis), or may be multifactorial (as in sepsis).
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Suggested Reading
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Gonzalez, R.S., Washington, K. (2016). Cholestasis. In: Non-Neoplastic Liver Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-31424-2_6
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DOI: https://doi.org/10.1007/978-3-319-31424-2_6
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