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Full Breast Ultrasonography of Malignant Lesions

  • Aristida Colan-Georges
Chapter
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Abstract

The main clinical aspects of breast cancer and ultrasonography are discussed and illustrated, including risk factors, prevention, the pathological aspects that determine image forming in mammography, and ductal echography. The old and new criteria for diagnosis using ultrasonography are discussed, along with the concepts of multicentric and multifocal cancer in ductal anatomical interpretation, which are important in the assessment of the extent of disease and to avoid risk of recurrence of breast cancer with conservative surgery. Other advantages of full breast ultrasonography include its ability to diagnose particular types of the breast cancer and lymph node metastases.

Keywords

Breast cancer Risk factors Large section Multifocal cancer Multicentric cancer Diffuse cancer Knobby carcinoma Stellate carcinoma Satellite lymph nodes 

References

  1. 1.
    Tot T (2007) The theory of the sick breast lobe and the possible consequences. Int J Surg Pathol 1:68–71Google Scholar
  2. 2.
    Georgescu AC, Andrei EM, Enachescu V, Bondari S (2013) New horizons in breast Doppler ductal echography: the positive and differential diagnosis of ductal ectasia, with etiopathological correlations. ECR, Vienna, EPOSTM. doi: 10.1594/ecr2013/C-0667
  3. 3.
    Grio R, Cellura A, Germao R et al (1998) Clinical efficacy of tamoxifen in the treatment of premenstrual mastodynia. Minerva Ginecol 50(3):101–103Google Scholar
  4. 4.
    Fujimoto Y, Hatama M, Tezuka K, Otani H et al (2005) Ultrasonic screening of the thyroid in the patients with breast complaints. In: Research and development in breast ultrasound. Springer, Tokyo, pp 167–169CrossRefGoogle Scholar
  5. 5.
    Fujimoto Y, Kato Y, Maekawa H et al (1988) Ultrasonic screening of thyroid in the patients with breast complaints. J Ultrasound Med 7:39–S283Google Scholar
  6. 6.
    Georgescu AC, Andrei ME, Manda A, Bondari S, Sendroiu I (2015) Contributions of imaging examinations in the diagnosis of the von Recklinghausen disease. ECR, Vienna, EPOSTM. doi: 10.1594/ecr2015/C-1014
  7. 7.
    Szymanowski K, Niepsuj-Biniaś J, Dera-Szymanowska A et al (2013) An influence of immunomodulation on Th1 and Th2 immune response in endometriosis in an animal model. Biomed Res Int 2013, Article ID 849492:7. doi: 10.1155/2013/849492 Google Scholar
  8. 8.
    Szymanowski K, Chmaj-Wierzchowska K, Yantczenko A et al (2009) Endometriosis prophylaxis and treatment with the newly developed xenogenic immunomodulator RESAN in an animal model. Eur J Obstet Gynecol Reprod Biol 142(2):145–148CrossRefPubMedGoogle Scholar
  9. 9.
    Foschini MP, Baldovini C, Ishikawa Y, Eusebi V (2012) The value of large sections in surgical pathology. Int J Breast Cancer 2012, Article ID 785947:7. doi: 10.1155/2012/785947 Google Scholar
  10. 10.
    Cheatle GL (1906) Early recognition of cancer of the breast. Br Med J 1:1205–1210CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Cheatle GL (1914) The relation between ducts and acini to cysts and cancer of the breast. J R Soc Med 7:241–244Google Scholar
  12. 12.
    Wellings SR, Jensen HM (1973) On the origin and progression of ductal carcinoma in the human breast. J Natl Cancer Inst 50(5):1111–1116PubMedGoogle Scholar
  13. 13.
    Foschini MP, Flamminio F, Miglio R et al (2007) The impact of large sections on the study of in situ and invasive duct carcinoma of the breast. Hum Pathol 38(12):1736–1743CrossRefPubMedGoogle Scholar
  14. 14.
    Tot T (2010) Cost-benefit analysis of using large-format histology sections in routine diagnostic breast care. Breast 19(4):284–288CrossRefPubMedGoogle Scholar
  15. 15.
    Tot T (2007) Clinical relevance of the distribution of the lesions in 500 consecutive breast cancer cases documented in large–format histologic sections. Cancer 110:2551–2560CrossRefPubMedGoogle Scholar
  16. 16.
    Egan RL (1982) Multicentric breast carcinomas: clinical-radiographic-pathologic whole organ studies and 10-year survival. Cancer 49(6):1123–1130CrossRefPubMedGoogle Scholar
  17. 17.
    Tot T, Gere M, Pekár G et al (2011) Breast cancer multifocality, disease extent, and survival. Hum Pathol 42(11):1761–1769CrossRefPubMedGoogle Scholar
  18. 18.
    Martin JE (1988) Atlas of mammography. Histologic and mammographic correlations, 2nd edn. Williams & Wilkins, Baltimore, pp 69–268Google Scholar
  19. 19.
    Gallager HS, Martin JE (1969) The study of breast carcinoma by correlated mammography and subserial whole organ sectioning. Early observations. Cancer 23:855–873CrossRefPubMedGoogle Scholar
  20. 20.
    Gallager HS, Martin JE (1969) Early phases in the development of breast cancer. Cancer 24:1170–1178CrossRefPubMedGoogle Scholar
  21. 21.
    Teboul M (2010) Advantages of ductal echography (DE) over conventional breast investigation in the diagnosis of breast malignancies. Med Ultrason 12(1):32–42PubMedGoogle Scholar
  22. 22.
    Baldovini C, Foschini MP (2012) Multifocality of breast cancer. In: Proceedings of the 27th congress of the Adriatic Society of Pathology, June 2012Google Scholar
  23. 23.
    Cooper AP (1840) On the anatomy of the breast. London, Longman, Orme, Green, Brown, and Longmans. (special collections, Scott Memorial Library, Thomas Jefferson University, http://jdc.jefferson.edu/cooper/)
  24. 24.
    Sobin LH, Gospodarowicz MK, Wittekind C (eds) (2009) TNM classification of malignant tumors. 7th edn. Wiley BlackwellGoogle Scholar
  25. 25.
    Saslow D, Solomon D, Lawson H et al (2012) American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. CA Cancer J Clin 62(30):147–172, Epub, Mar 14CrossRefPubMedPubMedCentralGoogle Scholar
  26. 26.
    American Cancer Society Guidelines for the Early Detection of Cancer (2014) www.cancer.org
  27. 27.
    Amy D (2010) Lobar Ultrasound of the Breast. In: Breast Cancer, 1.T. Tot (ed). © Springer-Verlag London Limited. doi:  10.1007/978-1-84996-314-5_8 Google Scholar
  28. 28.
    Amy D (2003) Sub-centimetric breast carcinoma. Echographic diagnosis. 13th International congress on the ultrasonic examination of the breast. International Breast Ultrasound School. The 10th meeting of Japan Association of Breast and Thyroid SonologyGoogle Scholar
  29. 29.
    Stavros AT, Rapp LC, Parker HS (2004) Breast ultrasound. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  30. 30.
    Mendelson EB, Baum JK, Berg WA et al (2003) Breast imaging reporting and data system BI-RADS: ultrasound, 1st edn. American College of Radiology, RestonGoogle Scholar
  31. 31.
    JSUM guidelines for mass image-forming lesions (2005) In: Ueno E, Shiina M, Kuboto K (eds) Research and development in breast ultrasound. Springer, Tokyo. pp 78–84Google Scholar
  32. 32.
    Japan Society of Ultrasonics in Medicine and JABTS- (Draft) (2003) Diagnostic guideline for mass image forming lesions. 13th International congress on the ultrasonic examination of the breast. International Breast Ultrasound School. The 10th meeting of Japan Association of Breast and Thyroid SonologyGoogle Scholar
  33. 33.
    Chang R-F, Huang SF, Chen D-R, Moon WK (2003) Detection of spiculation in three-dimensional breast ultrasound. 13th International congress on the ultrasonic examination of the breast. International Breast Ultrasound School. The 10th meeting of Japan Association of Breast and Thyroid SonologyGoogle Scholar
  34. 34.
    Kujiraoka Y, Ueno E, Yohno E, Morishima I, Tsunoda-Shimizu H (2005) Incident angle of the plunging artery of breast tumors. In: Research and development in breast ultrasound. Springer, Tokyo, pp 72–75CrossRefGoogle Scholar
  35. 35.
    LeCarpentier G (2008) 3D Doppler evaluation helps identify malignant breast lesions. Reuters Health. Radiology 249Google Scholar
  36. 36.
    Chou H-I (2003) Evaluation of periductal angiogenesis using contrast-enhanced ultrasound. 13th International congress on the ultrasonic examination of the breast. International Breast Ultrasound School. The 10th meeting of Japan Association of Breast and Thyroid SonologyGoogle Scholar
  37. 37.
    Ricci P, Cantisani V, Ballesio L et al (2007) Benign and malignant breast lesions: efficacy of real time contrast-enhanced ultrasound vs. magnetic resonance imaging. Ultraschall Med 28(1):57–62, PMID: 17304413 [PubMed – indexed for MEDLINE]CrossRefPubMedGoogle Scholar
  38. 38.
    Drudi FM, Cantisani V, Gnecchi M (2012) Contrast-enhanced ultrasound examination of the breast: a literature review. Ultraschall Med 33(7):E1–E7. doi: 10.1055/s-0031-1299408, Epub 2012 MayPubMedGoogle Scholar
  39. 39.
    Watermann DO, Foldi M, Hanjalic-Beck A et al (2005) Three-dimensional ultrasound for the assessment of breast lesions. Ultrasound Obstet Gynecol 25:592–598CrossRefPubMedGoogle Scholar
  40. 40.
    Vallone P, D’Angelo R, Filice S, Petrosino T, Rinaldo M, De Chiara A, Gallipoloi A (2005) Color-doppler using contrast medium in evaluating the response to neoadjuvant treatment in patients with locally advanced breast carcinoma. Anticancer Res 25:595–599, PubMedPubMedGoogle Scholar
  41. 41.
    Singh S, Pradhan S, Shukla RC, Ansari MA, Kumar A (2005) Color doppler ultrasound as an objective assessment tool for chemotherapeutic response in advanced breast cancer. Breast Cancer 12:45–51CrossRefPubMedGoogle Scholar
  42. 42.
    Kumar A, Singh S, Pradhan S et al (2007) Doppler ultrasound scoring to predict chemotherapeutic response in advanced breast cancer. World J Surg Oncol 5:99. doi: 10.1186/1477-7819-5-99 CrossRefPubMedPubMedCentralGoogle Scholar
  43. 43.
    Chung SY, Yang I, Kim D, Shin SJ, Bae SH (2003) Characteristic US findings of inflammatory breast carcinoma: comparison with MR imaging. 13th International congress on the ultrasonic examination of the breast. International Breast Ultrasound School. The 10th meeting of Japan Association of Breast and Thyroid SonologyGoogle Scholar
  44. 44.
    Lee KW, Chung SY, Yang I, Kim HD et al (2005) Inflammatory breast cancer. Clin Imaging 29(1):22–25. doi: 10.1016/j.clinimag.2004.03.006 PubMedGoogle Scholar
  45. 45.
    Papotti M, Gugliotta P, Ghiringhello B, Busolati G (1984) Association of breast carcinoma and multiple intraductal papillomas: an histological and immunohistochemical investigation. Histopathology 8(6):963–975CrossRefPubMedGoogle Scholar
  46. 46.
    Saad RS, Kanbour-Shakir A, Syed A, Kanbour A (2006) Sclerosing papillary lesion of the breast: a diagnosting pitfall for malignancy in fine needle aspiration biopsy. Diagn Cytopathol 34(2):114–118CrossRefPubMedGoogle Scholar
  47. 47.
    Lefkowitz M, Lefkowitz W, Wargotz ES (1994) Intraductal (intracystic) papillary carcinoma of the breast and its variants: a clinicopathological study of 77 cases. Hum Pathol 25(8):802–809CrossRefPubMedGoogle Scholar
  48. 48.
    Ueng S-H, Mezzetti T, Tavassoli AF (2009) Papillary neoplasms of the breast: a review. Arch Pathol Lab Med 133(6):893–907PubMedGoogle Scholar
  49. 49.
    Svane G (2005) Ductal Carcinoma in Situ (DCIS): incidence, prognosis, and diagnostic aspects on mammography, galactography, and needle biopsies. In: Research and development in breast ultrasound. Springer, Tokyo, pp 114–118CrossRefGoogle Scholar
  50. 50.
    Takebe K, Izumori A (2005) The ultrasonographic diagnosis of nonpalpable DCIS without calcification on mammography and nipple discharge: advocacy of a new term, 3 non-DCIS. In: Research and development in breast ultrasound. Springer, Tokyo, pp 119–126CrossRefGoogle Scholar
  51. 51.
    Tanaka K, Sakuma H, Sakamoto G et al (2005) Characteristic mammography and ultrasonography findings of ductal carcinoma in situ of the breast arising in sclerosing adenosis. In: Research and development in breast ultrasound. Springer, Tokyo, pp 135–140CrossRefGoogle Scholar
  52. 52.
    Silverstein MJ, Recht A, Lagios M (eds) (2002) Ductal carcinoma in situ of the breast, 2nd edn. Silverstein/Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  53. 53.
    Kim EK, Oh KK, Shin HC (1996) Paget’s disease of the breast: significance of mammographic findings. J Korean Radiol Soc 34(4):551–555Google Scholar
  54. 54.
    Choi SH, Chung SY, Lee KW et al (2001) Ultrasonography in Paget’s disease of the breast: comparison with mammographic findings. J Korean Soc Med Ultrasound 20(20):137–142Google Scholar
  55. 55.
    Bacchetta J, Juillard L, Cochat P et al (2009) Paraneoplastic glomerular diseases and malignancies. Crit Rev Oncol Hematol 70:39–58CrossRefPubMedGoogle Scholar
  56. 56.
    Kijima Y, Yoshinaka H, Owaki T et al (2004) Breast cancer with nephrotic syndrome: report of two cases. Surg Today 34(9):755–759CrossRefPubMedGoogle Scholar
  57. 57.
    Valcamonico F, Ferrari V, Simoncini E et al (2004) Paraneoplastic nephrotic syndrome in advanced breast cancer patient. A case report. Tumori 90(1):154–156PubMedGoogle Scholar
  58. 58.
    Yoshizawa H, Akimoto T, Nishino K et al (2011) Nephrotic syndrome and renal failure in a patient with metastatic breast cancer. Clin Exp Nephrol 15(4):567–571. doi: 10.007/s10157-011-0425-1, Epub 2011Mar 18CrossRefPubMedGoogle Scholar
  59. 59.
    Oh KK (2003) The Paget’s disease and pagetoid extension of the breast cancers: 3-D sonographic and pathologic correlation. 13th International congress on the ultrasonic examination of the breast. International Breast Ultrasound School. The 10th meeting of Japan Association of Breast and Thyroid SonologyGoogle Scholar
  60. 60.
    Sakita I, Yoshida T, Sohma I, Fukuchi N, Izawa H, Ebisui C, Hasuike Y, Ishizawa H, Kobayashi Y, Kotera I, Fujimoto T (2003) Determination of indication for sentinel lymph node biopsy using Doppler imaging. 13th International congress on the ultrasonic examination of the breast. International Breast Ultrasound School. The 10th meeting of Japan Association of Breast and Thyroid SonologyGoogle Scholar
  61. 61.
    Wisner ER, Ferrara KW, Short RE, Ottoboni TB, Gabe JD, Patel D (2003) Sentinel node detection using contrast-enhanced power doppler ultrasound lymphography. Invest Radiol 38(60):358–365PubMedGoogle Scholar
  62. 62.
    Britton PD, Goud A, Godward S, Barter S et al (2009) Use of ultrasound-guided axillary node core biopsy in staging of early breast cancer. Eur Radiol 19(3):561–569CrossRefPubMedGoogle Scholar
  63. 63.
    Chung SY, Kim E-K, Oh KK (2003) Imaging findings of axillary abnormalities.13th International congress on the ultrasonic examination of the breast. International Breast Ultrasound School. The 10th meeting of Japan Association of Breast and Thyroid SonologyGoogle Scholar
  64. 64.
    Okamoto T, Horiuchi K, Kodama H et al (2005) Probability of axillary lymph node metastasis when sentinel lymph node biopsy is negative in women with clinically node negative breast cancer: a Bayesian approach. Breast Cancer 02/12(3):203–210. doi: 10.2325/jbcs.12.203 Google Scholar
  65. 65.
    Kusama M, Kawamoto A, Kaise H et al (2003) Ultrasound with tissue harmonic imaging in detection of axillary lymph node metastases in breast cancer patients. 13th International congress on the ultrasonic examination of the breast. International Breast Ultrasound School. The 10th meeting of Japan Association of Breast and Thyroid SonologyGoogle Scholar
  66. 66.
    Esen G, Gurses B, Ylmaz MH et al (2005) Gray scale and power doppler US in the preoperative evaluation of axillary metastases in breast cancer patients with no palpable lymph nodes. Eur Radiol 15(6):1215–1223CrossRefPubMedGoogle Scholar
  67. 67.
    Rashmi S, Govardhan HB, Satyajt P et al (2014) Colour doppler – an evaluation tool for assessment of breast tumor size, axillary lymph node size and chemotherapeutic response. J Cancer Treat Res 2(2):9–15. doi: 10.11648/j.jctr.20140202.11 CrossRefGoogle Scholar
  68. 68.
    Han SY, Kim HH (2003) Parasternal sonography of the internal mammary lymphatics in breast cancer. 13th International congress on the ultrasonic examination of the breast. International Breast Ultrasound School. The 10th meeting of Japan Association of Breast and Thyroid SonologyGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Aristida Colan-Georges
    • 1
  1. 1.Department of Radiology and Imaging DiagnosisCounty Emergency Clinical HospitalCraiovaRomania

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