Comorbidities of Restless Legs Syndrome and Periodic Limb Movement Disorder
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Because restless legs syndrome (RLS) is a common disorder, it is not unexpected to find that patients with RLS also suffer from additional disorders. As a result, it is important to be skeptical about reports that RLS is associated with a given disorder. However, certain disorders (or conditions) are so clearly associated with RLS that they can be considered causative or risk factors (see Table 1.3). Others are plausibly associated but have not been studied sufficiently to be convincingly associated; the better-established associations in the authors’ opinion are listed in Table 3.1. It should be noted that not only physical disorders but also psychiatric disorders can occur with RLS . Both depression and anxiety can overlap with RLS symptoms. It also seems likely that anxiety and depression may be caused by RLS, perhaps mediated by sleep deprivation . In addition, the common treatment of anxiety and depression with SSRI or SNRI medications typically makes RLS worse. This in turn worsens the anxiety and depression triggering an increase in antidepressant medication which creates a viscous cycle of treatment. When antidepressant medications are started after RLS symptoms have been disruptive, it is often likely that the medications can be discontinued once the RLS symptoms are controlled.
KeywordsEating Disorder Sleep Disorder Sleep Deprivation Antidepressant Medication Dopaminergic Medication
- 8.American Academy of Sleep Medicine. International classification of sleep disorders: diagnostic and coding manual. 2nd ed. Chicago: American Association of Sleep Medicine; 2005.Google Scholar
- 9.Zucconi M, Ferri R, Allen R, Baier PC, Bruni O, Chokroverty S, et al. International Restless Legs Syndrome Study Group (IRLSSG). The official World Association of Sleep Medicine (WASM) standards for recording and scoring periodic leg movements in sleep (PLMS) and wakefulness (PLMW) developed in collaboration with a task force from the International Restless Legs Syndrome Study Group (IRLSSG). Sleep Med. 2006;7:175–83.Google Scholar