Skip to main content

Quantitative EEG in Neonatal Seizures

  • Chapter
  • First Online:
Continuous EEG Monitoring

Abstract

While continuous EEG (cEEG) remains the ideal method of monitoring for seizures in neonates, quantitative EEG (qEEG) trends are often used. In particular, amplitude-integrated EEG (aEEG) is increasingly popular and can be a helpful complementary tool to cEEG monitoring. In situations in which cEEG is not practical, aEEG may be used as a stand-alone method of neuromonitoring. Alternately, aEEG may be used in conjunction with cEEG to allow bedside caregivers in the neonatal unit to monitor EEG trends in real time or to facilitate rapid review of neonatal cEEG by a neurophysiologist. Understanding the fundamentals of how aEEG is recorded and displayed helps clinicians accurately interpret background patterns and identify seizures. Specific factors can impact accuracy of aEEG for seizure detection; modification of these factors can improve sensitivity and specificity. Awareness of limitations of aEEG facilitates appropriate clinical use.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Abend NS, Wusthoff CJ, Goldberg EM, Dlugos DJ. Electrographic seizures and status epilepticus in critically ill children and neonates with encephalopathy. Lancet Neurol. 2013;12(12):1170–9. doi:10.1016/S1474-4422(13)70246-1.

    Article  PubMed  Google Scholar 

  2. Dysart KC, Kirpalani HM, Kirpalani HM, Wusthoff CJ, Seshia SS. Amplitude-integrated electroencephalography: a runaway horse? Can J Neurol Sci. 2012;39(3):267–8.

    Article  PubMed  Google Scholar 

  3. El-Dib M, Chang T, Tsuchida TN, Clancy RR. Amplitude-integrated electroencephalography in neonates. Pediatr Neurol. 2009;41(5):315–26. doi:10.1016/j.pediatrneurol.2009.05.002.

    Article  PubMed  Google Scholar 

  4. Frenkel N, Friger M, Meledin I, Berger I, Marks K, Bassan H, Shany E. Neonatal seizure recognition – comparative study of continuous-amplitude integrated EEG versus short conventional EEG recordings. Clin Neurophysiol. 2011;122(6):1091–7. doi:10.1016/j.clinph.2010.09.028.

    Article  PubMed  Google Scholar 

  5. Glass HC, Kan J, Bonifacio SL, Ferriero DM. Neonatal seizures: treatment practices among term and preterm infants. Pediatr Neurol. 2012;46(2):111–5. doi:10.1016/j.pediatrneurol.2011.11.006.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Glass HC, Wusthoff CJ, Shellhaas RA. Amplitude-integrated electro-encephalography: the child neurologist’s perspective. J Child Neurol. 2013;28(10):1342–50. doi:10.1177/0883073813488663.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Hellstrom-Westas L, de Vries LS, Rosen I. An atlas of amplitude-integrated EEGs in the newborn. New York: Informa Healthcare; 2008.

    Book  Google Scholar 

  8. Hellstrom-Westas L, Rosén I, de Vries LS, Greisen G. Amplitude-integrated EEG classification and interpretation in preterm and term infants. NeoReviews. 2006;7(2):e76–87.

    Article  Google Scholar 

  9. Maynard D, Prior PF, Scott DF. A continuous monitoring device for cerebral activity. Electroencephalogr Clin Neurophysiol. 1969;27(7):672–3.

    CAS  PubMed  Google Scholar 

  10. Murray DM, Boylan GB, Ali I, Ryan CA, Murphy BP, Connolly S. Defining the gap between electrographic seizure burden, clinical expression and staff recognition of neonatal seizures. Arch Dis Child Fetal Neonatal Ed. 2008;93(3):F187–91.

    Article  CAS  PubMed  Google Scholar 

  11. Rennie JM, Chorley G, Boylan GB, Pressler R, Nguyen Y, Hooper R. Non-expert use of the cerebral function monitor for neonatal seizure detection. Arch Dis Child Fetal Neonatal Ed. 2004;89(1):F37–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Shah DK, de Vries LS, Hellstrom-Westas L, Toet MC, Inder TE. Amplitude-integrated electroencephalography in the newborn: a valuable tool. Pediatrics. 2008;122(4):863–5. doi:10.1542/peds.2008-1000.

    Article  PubMed  Google Scholar 

  13. Shah DK, Mackay MT, Lavery S, Watson S, Harvey AS, Zempel J, Mathur A, Inder TE. Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants. Pediatrics. 2008;121(6):1146–54. doi:10.1542/peds.2007-1839.

    Article  PubMed  Google Scholar 

  14. Shah NA, Van Meurs KP, Davis AS. Amplitude-integrated electroencephalography: a survey of practices in the United States. Am J Perinatol. 2014. doi:10.1055/s-0034-1395483.

    Google Scholar 

  15. Shah NA, Wusthoff CJ. How to use: amplitude-integrated EEG (aEEG). Arch Dis Child Educ Pract Ed. 2014. doi:10.1136/archdischild-2013-305676.

    Google Scholar 

  16. Shellhaas RA, Chang T, Tsuchida T, Scher MS, Riviello JJ, Abend NS, Nguyen S, Wusthoff CJ, Clancy RR. The American Clinical Neurophysiology Society’s Guideline on Continuous Electroencephalography Monitoring in Neonates. J Clin Neurophysiol. 2011;28(6):611–7. doi:10.1097/WNP.0b013e31823e96d7.

    Article  PubMed  Google Scholar 

  17. Shellhaas RA, Soaita AI, Clancy RR. Sensitivity of amplitude-integrated electroencephalography for neonatal seizure detection. Pediatrics. 2007;120(4):770–7. doi:10.1542/peds.2007-0514.

    Article  PubMed  Google Scholar 

  18. Tao JD, Mathur AM. Using amplitude-integrated EEG in neonatal intensive care. J Perinatol. 2010;30(Suppl):S73–81. doi:10.1038/jp.2010.93.

    Article  PubMed  Google Scholar 

  19. Tsuchida TN, Wusthoff CJ, Shellhaas RA, Abend NS, Hahn CD, Sullivan JE, Nguyen S, Weinstein S, Scher MS, Riviello JJ, Clancy RR. American clinical neurophysiology society standardized EEG terminology and categorization for the description of continuous EEG monitoring in neonates: report of the American Clinical Neurophysiology Society critical care monitoring committee. J Clin Neurophysiol. 2013;30(2):161–73.

    Article  PubMed  Google Scholar 

  20. Wusthoff CJ, Shellhaas RA, Clancy RR. Limitations of single-channel EEG on the forehead for neonatal seizure detection. J Perinatol. 2009;29(3):237–42. doi:10.1038/jp.2008.195.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Courtney J. Wusthoff MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Knowles, J.K., Wusthoff, C.J. (2017). Quantitative EEG in Neonatal Seizures. In: Husain, A., Sinha, S. (eds) Continuous EEG Monitoring. Springer, Cham. https://doi.org/10.1007/978-3-319-31230-9_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-31230-9_13

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-31228-6

  • Online ISBN: 978-3-319-31230-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics