Abstract
While continuous EEG (cEEG) remains the ideal method of monitoring for seizures in neonates, quantitative EEG (qEEG) trends are often used. In particular, amplitude-integrated EEG (aEEG) is increasingly popular and can be a helpful complementary tool to cEEG monitoring. In situations in which cEEG is not practical, aEEG may be used as a stand-alone method of neuromonitoring. Alternately, aEEG may be used in conjunction with cEEG to allow bedside caregivers in the neonatal unit to monitor EEG trends in real time or to facilitate rapid review of neonatal cEEG by a neurophysiologist. Understanding the fundamentals of how aEEG is recorded and displayed helps clinicians accurately interpret background patterns and identify seizures. Specific factors can impact accuracy of aEEG for seizure detection; modification of these factors can improve sensitivity and specificity. Awareness of limitations of aEEG facilitates appropriate clinical use.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abend NS, Wusthoff CJ, Goldberg EM, Dlugos DJ. Electrographic seizures and status epilepticus in critically ill children and neonates with encephalopathy. Lancet Neurol. 2013;12(12):1170–9. doi:10.1016/S1474-4422(13)70246-1.
Dysart KC, Kirpalani HM, Kirpalani HM, Wusthoff CJ, Seshia SS. Amplitude-integrated electroencephalography: a runaway horse? Can J Neurol Sci. 2012;39(3):267–8.
El-Dib M, Chang T, Tsuchida TN, Clancy RR. Amplitude-integrated electroencephalography in neonates. Pediatr Neurol. 2009;41(5):315–26. doi:10.1016/j.pediatrneurol.2009.05.002.
Frenkel N, Friger M, Meledin I, Berger I, Marks K, Bassan H, Shany E. Neonatal seizure recognition – comparative study of continuous-amplitude integrated EEG versus short conventional EEG recordings. Clin Neurophysiol. 2011;122(6):1091–7. doi:10.1016/j.clinph.2010.09.028.
Glass HC, Kan J, Bonifacio SL, Ferriero DM. Neonatal seizures: treatment practices among term and preterm infants. Pediatr Neurol. 2012;46(2):111–5. doi:10.1016/j.pediatrneurol.2011.11.006.
Glass HC, Wusthoff CJ, Shellhaas RA. Amplitude-integrated electro-encephalography: the child neurologist’s perspective. J Child Neurol. 2013;28(10):1342–50. doi:10.1177/0883073813488663.
Hellstrom-Westas L, de Vries LS, Rosen I. An atlas of amplitude-integrated EEGs in the newborn. New York: Informa Healthcare; 2008.
Hellstrom-Westas L, Rosén I, de Vries LS, Greisen G. Amplitude-integrated EEG classification and interpretation in preterm and term infants. NeoReviews. 2006;7(2):e76–87.
Maynard D, Prior PF, Scott DF. A continuous monitoring device for cerebral activity. Electroencephalogr Clin Neurophysiol. 1969;27(7):672–3.
Murray DM, Boylan GB, Ali I, Ryan CA, Murphy BP, Connolly S. Defining the gap between electrographic seizure burden, clinical expression and staff recognition of neonatal seizures. Arch Dis Child Fetal Neonatal Ed. 2008;93(3):F187–91.
Rennie JM, Chorley G, Boylan GB, Pressler R, Nguyen Y, Hooper R. Non-expert use of the cerebral function monitor for neonatal seizure detection. Arch Dis Child Fetal Neonatal Ed. 2004;89(1):F37–40.
Shah DK, de Vries LS, Hellstrom-Westas L, Toet MC, Inder TE. Amplitude-integrated electroencephalography in the newborn: a valuable tool. Pediatrics. 2008;122(4):863–5. doi:10.1542/peds.2008-1000.
Shah DK, Mackay MT, Lavery S, Watson S, Harvey AS, Zempel J, Mathur A, Inder TE. Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants. Pediatrics. 2008;121(6):1146–54. doi:10.1542/peds.2007-1839.
Shah NA, Van Meurs KP, Davis AS. Amplitude-integrated electroencephalography: a survey of practices in the United States. Am J Perinatol. 2014. doi:10.1055/s-0034-1395483.
Shah NA, Wusthoff CJ. How to use: amplitude-integrated EEG (aEEG). Arch Dis Child Educ Pract Ed. 2014. doi:10.1136/archdischild-2013-305676.
Shellhaas RA, Chang T, Tsuchida T, Scher MS, Riviello JJ, Abend NS, Nguyen S, Wusthoff CJ, Clancy RR. The American Clinical Neurophysiology Society’s Guideline on Continuous Electroencephalography Monitoring in Neonates. J Clin Neurophysiol. 2011;28(6):611–7. doi:10.1097/WNP.0b013e31823e96d7.
Shellhaas RA, Soaita AI, Clancy RR. Sensitivity of amplitude-integrated electroencephalography for neonatal seizure detection. Pediatrics. 2007;120(4):770–7. doi:10.1542/peds.2007-0514.
Tao JD, Mathur AM. Using amplitude-integrated EEG in neonatal intensive care. J Perinatol. 2010;30(Suppl):S73–81. doi:10.1038/jp.2010.93.
Tsuchida TN, Wusthoff CJ, Shellhaas RA, Abend NS, Hahn CD, Sullivan JE, Nguyen S, Weinstein S, Scher MS, Riviello JJ, Clancy RR. American clinical neurophysiology society standardized EEG terminology and categorization for the description of continuous EEG monitoring in neonates: report of the American Clinical Neurophysiology Society critical care monitoring committee. J Clin Neurophysiol. 2013;30(2):161–73.
Wusthoff CJ, Shellhaas RA, Clancy RR. Limitations of single-channel EEG on the forehead for neonatal seizure detection. J Perinatol. 2009;29(3):237–42. doi:10.1038/jp.2008.195.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Knowles, J.K., Wusthoff, C.J. (2017). Quantitative EEG in Neonatal Seizures. In: Husain, A., Sinha, S. (eds) Continuous EEG Monitoring. Springer, Cham. https://doi.org/10.1007/978-3-319-31230-9_13
Download citation
DOI: https://doi.org/10.1007/978-3-319-31230-9_13
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-31228-6
Online ISBN: 978-3-319-31230-9
eBook Packages: MedicineMedicine (R0)