Abstract
Bi-dimensional networks of dissociated neurons developing in vitro and coupled to Micro-Electrode Arrays devices (MEAs) represent a valid experimental model for studying the universal mechanisms governing the formation and conservation of neuronal cell assemblies (Marom and Shahaf in Q Rev Biophys 35(1):63–87, 2002).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Beggs JM, Plenz D (2004) Neuronal avalanches are diverse and precise activity patterns that are stable for many hours in cortical slice cultures. J Neurosci 24:5216–5229
Behravesh E, Emami K et al (2005) Comparison of genotoxic damage in monolayer cell cultures and three-dimensional tissue-like cell assemblies. Adv Space Res 35(2):260–267
Birgersdotter A, Sandberg R et al (2005) Gene expression perturbation in vitro–a growing case for three-dimensional (3D) culture systems. Semin Cancer Biol 15(5):405–412
Chun TH, Hotary KB et al (2006) A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell 125(3):577–591
Cukierman E, Pankov R et al (2001) Taking cell-matrix adhesions to the third dimension. Science 294(5547):1708–1712
Cullen DK, Wolf JA et al (2011) Neural tissue engineering and biohybridized microsystems for neurobiological investigation in vitro (part 1). Crit Rev Biomed Eng 39(3):201–240
Dranias MR, Ju H et al (2013) Short-term memory in networks of dissociated cortical neurons. J Neurosci Off J Soc Neurosci 33(5):1940–1953
Eytan D, Marom S (2006) Dynamics and effective topology underlying synchronization in networks of cortical neurons. J Neurosci 26(33):8465–8476
Friedl P, Zanker KS et al (1998) Cell migration strategies in 3-D extracellular matrix: differences in morphology, cell matrix interactions, and integrin function. Microsc Res Tech 43(5):369–378
Gal A, Eytan D et al (2010) Dynamics of excitability over extended timescales in cultured cortical neurons. J Neurosci 30(48):16332–16342
Hasselmo ME (1995) Neuromodulation and cortical function: modeling the physiological basis of behavior. Behav Brain Res 67(1):1–27
Hindie M, Vayssade M et al (2006) Interactions of B16F10 melanoma cells aggregated on a cellulose substrate. J Cell Biochem 99(1):96–104
Liu H, Lin J et al (2006) Effect of 3D scaffold and dynamic culture condition on the global gene expression profile of mouse embryonic stem cells. Biomaterials 27(36):5978–5989
Marom S, Eytan D (2005) Learning in ex-vivo developing networks of cortical neurons. Prog Brain Res 147:189–199
Marom S, Shahaf G (2002) Development, learning and memory in large random networks of cortical neurons: lessons beyond anatomy. Q Rev Biophys 35(1):63–87
Pautot S, Wyart C et al (2008) Colloid-guided assembly of oriented 3D neuronal networks. Nat Methods 5(8):735–740
Pedersen JA, Swartz MA (2005) Mechanobiology in the third dimension. Ann Biomed Eng 33(11):1469–1490
Rieke F, Warland D et al (1997) Spikes: exploring the neural code. The MIT Press, Cambridge, Massachusetts
Rolston JD, Wagenaar DA et al (2007) Precisely timed spatiotemporal patterns of neural activity in dissociated cortical cultures. Neuroscience 148(1):294–303
Shahaf G, Marom S (2001) Learning in networks of cortical neurons. J Neurosci 21(22):8782–8788
Smalley KS, Lioni M et al (2006) Life isn’t flat: taking cancer biology to the next dimension. In Vitro Cell Dev Biol Anim 42(8–9):242–247
Sporns O, Tononi G (2001) Classes of network connectivity and dynamics. Complexity 7(1):28–38
Timofeev I, Grenier F et al (2000a) Origin of slow cortical oscillations in deafferented cortical slabs. Cereb Cortex (New York, NY: 1991) 10(12):1185–1199
Timofeev I, Grenier F et al (2000b) Impact of intrinsic properties and synaptic factors on the activity of neocortical networks in vivo. J Physiol, Paris 94(5–6):343–355
van Pelt J, Wolters PS et al (2004) Long-term characterization of firing dynamics of spontaneous bursts in cultured neural networks. IEEE Trans Biomed Eng 51(11):2051–2062
Wagenaar DA, Madhavan R et al (2005) Controlling bursting in cortical cultures with closed-loop multi-electrode stimulation. J Neurosci 25(3):680–688
Willerth SM, Arendas KJ et al (2006) Optimization of fibrin scaffolds for differentiation of murine embryonic stem cells into neural lineage cells. Biomaterials 27(36):5990–6003
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Frega, M. (2016). Introduction. In: Neuronal Network Dynamics in 2D and 3D in vitro Neuroengineered Systems. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-319-30237-9_1
Download citation
DOI: https://doi.org/10.1007/978-3-319-30237-9_1
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-30236-2
Online ISBN: 978-3-319-30237-9
eBook Packages: EngineeringEngineering (R0)