Abstract
Movement disorders belong to the most common neurologic illnesses. In typical cases diagnoses are accurately established by clinical means. In early and monosymptomatic stages, however, clinical diagnoses remain uncertain and may benefit from molecular imaging techniques picking up specific metabolic patterns or changes in neurotransmitter systems. Most established for this purpose are the assessment of the metabolic pattern of fluorodeoxyglucose (FDG) and changes in dopaminergic neurotransmission. These techniques generally allow to separate Parkinson’s disease (PD) from other neurodegenerative parkinsonian syndromes (PS), to characterize dementia with Lewy bodies (DLB), and to rule out diseases which may mimic neurodegenerative PS such as symptomatic parkinsonism and various tremor syndromes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184
Hughes AJ, Daniel SE, Lees AJ (1993) The clinical features of Parkinson’s disease in 100 histologically proven cases. Adv Neurol 60:595–599
Catafau AM, Tolosa E (2004) Impact of dopamine transporter SPECT using 123I-Ioflupane on diagnosis and management of patients with clinically uncertain Parkinsonian syndromes. Mov Disord 19:1175–1182
Hughes AJ, Daniel SE, Ben-Shlomo Y, Lees AJ (2002) The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service. Brain 125:861–870
Meara J, Bhowmick BK, Hobson P (1999) Accuracy of diagnosis in patients with presumed Parkinson’s disease. Age Ageing 28:99–102
Eckert T, Barnes A, Dhawan V et al (2005) FDG PET in the differential diagnosis of parkinsonian disorders. Neuroimage 26:912–921
Zhao P, Zhang B, Gao S (2011) 18F-FDG PET study on the idiopathic Parkinson’s disease from several parkinsonian-plus syndromes. Parkinsonism Relat Disord 18(Suppl 1):S60–S62
Varrone A, Halldin C (2012) New developments of dopaminergic imaging in Parkinson’s disease. Q J Nucl Med Mol Imaging 56:68–82
Seibyl J, Russell D, Jennings D, Marek K (2012) The molecular basis of dopaminergic brain imaging in Parkinson’s disease. Q J Nucl Med Mol Imaging 56:4–16
Cochrane CJ, Ebmeier KP (2013) Diffusion tensor imaging in parkinsonian syndromes: a systematic review and meta-analysis. Neurology 80:857–864
Meijer FJ, Bloem BR, Mahlknecht P, Seppi K, Goraj B (2013) Update on diffusion MRI in Parkinson’s disease and atypical parkinsonism. J Neurol Sci 332:21–29
Barthel H, Schroeter ML, Hoffmann K-T, Sabri O (2015) PET/MR in dementia and other neurodegenerative diseases. Semin Nucl Med 45:224–233
Booij J, Tissingh G, Winogrodzka A, van Royen EA (1999) Imaging of the dopaminergic neurotransmission system using single-photon emission tomography and positron emission tomography in patients with parkinsonism. Eur J Nucl Med 26:171–182
Dagher A (2001) Functional imaging in Parkinson’s disease. Semin Neurol 21:23–32
Huang C, Ravdin LD, Nirenberg MJ et al (2013) Neuroimaging markers of motor and nonmotor features of Parkinson’s disease: an 18f fluorodeoxyglucose positron emission computed tomography study. Dement Geriatr Cogn Disord 35:183–196
Borghammer P, Hansen SB, Eggers C et al (2012) Glucose metabolism in small subcortical structures in Parkinson’s disease. Acta Neurol Scand 125:303–310
Tatsch K (2010) Extrapyramidal syndromes: PET and SPECT. Neuroimaging Clin N Am 20:57–68
Bruck A, Aalto S, Rauhala E, Bergman J, Marttila R, Rinne JO (2009) A follow-up study on 6-[18F]fluoro-L-dopa uptake in early Parkinson’s disease shows nonlinear progression in the putamen. Mov Disord 24:1009–1015
Hsiao IT, Weng YH, Hsieh CJ et al (2014) Correlation of Parkinson disease severity and 18F-DTBZ positron emission tomography. JAMA Neurol 71:758–766
Tatsch K (2016) Movement disorders. In: von Schulthess GK (ed) Molecular anatomic imaging PET/CT, PET/MR and SPECT/CT. Wolters Kluwer, Philadelphia, pp 210–217
la Fougere C, Popperl G, Levin J et al (2011) The value of the dopamine D2/3 receptor ligand 18F-desmethoxyfallypride for the differentiation of idiopathic and nonidiopathic parkinsonian syndromes. J Nucl Med 51:581–587
Pirker W, Asenbaum S, Bencsits G et al (2000) [123I]beta-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration. Mov Disord 15:1158–1167
Klaffke S, Kuhn AA, Plotkin M et al (2006) Dopamine transporters, D2 receptors, and glucose metabolism in corticobasal degeneration. Mov Disord 21:1724–1727
Walker Z, Possin KL, Boeve BF, Aarsland D (2015) Lewy body dementias. Lancet 386:1683–1697
Papathanasiou ND, Boutsiadis A, Dickson J, Bomanji JB (2012) Diagnostic accuracy of I-123 FP-CIT (DaTSCAN) in dementia with Lewy bodies: a meta-analysis of published studies. Parkinsonism Relat Disord 18:225–229
Diaz-Corrales FJ, Sanz-Viedma S, Garcia-Solis D, Escobar-Delgado T, Mir P (2010) Clinical features and 123I-FP-CIT SPECT imaging in drug-induced parkinsonism and Parkinson’s disease. Eur J Nucl Med Mol Imaging 37:556–564
Gaig C, Marti MJ, Tolosa E et al (2006) 123I-Ioflupane SPECT in the diagnosis of suspected psychogenic Parkinsonism. Mov Disord 21:1994–1998
Zijlmans J, Evans A, Fontes F et al (2007) [123I] FP-CIT spect study in vascular parkinsonism and Parkinson’s disease. Mov Disord 22:1278–1285
Contrafatto D, Mostile G, Nicoletti A et al (2012) [(123) I]FP-CIT-SPECT asymmetry index to differentiate Parkinson’s disease from vascular parkinsonism. Acta Neurol Scand 126:12–16
Jeon BS, Jeong JM, Park SS et al (1998) Dopamine transporter density measured by [123I]beta-CIT single-photon emission computed tomography is normal in dopa-responsive dystonia. Ann Neurol 43:792–800
Benamer TS, Patterson J, Grosset DG et al (2000) [123I]-FP-CIT SPECT imaging: the [123I]-FP-CIT study group. Mov Disord 15:503–510
Trocello JM, Zanotti-Fregonara P, Roze E et al (2008) Dopaminergic deficit is not the rule in orthostatic tremor. Mov Disord 23:1733–1738
Coria F, Gimenez-Garcia M, Samaranch L, Mora FJ, Sampol-Bas C, Pastor P (2012) Nigrostriatal dopaminergic function in subjects with isolated action tremor. Parkinsonism Relat Disord 18:49–53
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Tatsch, K. (2016). Nuclear Imaging of Movement Disorders. In: Hodler, J., Kubik-Huch, R., von Schulthess, G. (eds) Diseases of the Brain, Head and Neck, Spine 2016-2019. Springer, Cham. https://doi.org/10.1007/978-3-319-30081-8_27
Download citation
DOI: https://doi.org/10.1007/978-3-319-30081-8_27
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-30080-1
Online ISBN: 978-3-319-30081-8
eBook Packages: MedicineMedicine (R0)