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Interplay Between Autophagy and Inflammasomes

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Autophagy Networks in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

The autophagy and inflammasome are two ancient innate immune pathways for controlling invading pathogens that are linked mutual regulation. In addition to controlling the cellular metabolic homeostasis through nutrient recycling, the autophagy “self-eating” process is also responsible for the degradation of damaged organelles, aggregated protein complexes, and pathogens to protect the integrity of the organism. As a cytosolic pathogen recognition receptor (PRR) complex, the inflammasome both induces and induced by autophagy through direct interaction with major autophagy proteins or through the effects of secondary molecules, such as mitochondrial reactive oxygen species and mitochondrial DNA. While the underlying molecular mechanisms of inflammasome activation and regulation are largely unknown, much of current knowledge has been established through investigation of the role of autophagy in innate immune response. Many of the newly uncovered links between autophagy and inflammasome have raised new questions about the mechanism controlling inflammasome function, which are highlighted in this chapter.

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Abbreviations

8-OH-dG:

Oxidized nucleoside 8-hydroxy-guanosine

ASC:

Caspase recruitment domain adapter protein

BMDCs:

Bone marrow derived dendritic cells

BMDMs:

Bone marrow-derived macrophages

BRCC3:

BRCA1-BRCA2-containing complex 3

BRISC:

BRCC36-containing isopeptidase

DAMP:

Danger-associated molecular pattern

DHA:

Omega-3 (ω3) fatty acid docosahexaenoic acid

EM:

Electron microscope

FMF:

Familial Mediterranean fever

IFI:

Interferon-gamma-inducible gene

IL:

Interleukin

LeTx:

Anthrax lethal toxin

LRR:

Leucine-rich repeat

LUBAC:

Linear ubiquitin assembly complex

MAVS:

Mitochondrial antiviral signaling

MDP:

Muramyl dipeptide

MEFs:

Mouse embryonic fibroblasts

mtDNA:

Mitochondrial DNA

mtROS:

Mitochondrial ROS

NACHT, NOD, NB-ARC:

Adapter protein; central nucleotide-binding and oligomerization domain

NLR:

Nod-like receptor

PAMP:

Pathogen-associated molecular pattern

PRR:

Pathogen recognition receptor

pyrin or CARD domain:

Protein binding domain

Rip2:

Receptor interacting protein 2

RLH:

RIG-I-like helicase

TLR:

Toll-like receptor

TUFM:

Tu translation elongation factor

VDAC1:

Voltage dependent anion channel 1

VSV:

Vesicular stomatitis virus

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Authors and Affiliations

  1. Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, ZNI 521, Los Angeles, CA, 90033, USA

    Qiming Liang & Jianning Ge

  2. Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA

    Xi Jin

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  1. Qiming Liang
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  2. Jianning Ge
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Correspondence to Qiming Liang .

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  1. Centre de Recherche des Cordeliers, UMRS 1138 – Team 11,, Paris, France

    Maria Chiara Maiuri

  2. Multi Medica Fondazione Onlus, Milan, Italy

    Daniela De Stefano

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Liang, Q., Ge, J., Jin, X. (2016). Interplay Between Autophagy and Inflammasomes. In: Maiuri, M., De Stefano, D. (eds) Autophagy Networks in Inflammation. Progress in Inflammation Research. Springer, Cham. https://doi.org/10.1007/978-3-319-30079-5_4

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