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Microfluidic Platforms for Quantitative Biology Studies in Model Organisms

  • Daniel A. Porto
  • Tel M. Rouse
  • Adriana San-MiguelEmail author
  • Hang LuEmail author
Chapter

Abstract

The use of lab-on-chip tools has been adopted in a wide variety of scientific fields. Hundreds of applications that speed up, miniaturize, or enable otherwise unfeasible assays have emerged in the last couple of decades [1, 2]. The microfluidic toolbox offers several advantages which make it a very attractive resource for biological studies: reduced sample volume, control of spatiotemporal chemical compositions, streamlined assays, precise and predictable fluid flow regimes, portability, and integration with sensors, actuators, controllers, and automation systems [1–3]. The main drive of the field has thus far focused on the development of microfluidic tools that replace conventional methods with proof-of-principle applications. However, widespread adoption of these technologies for fundamental research is still in progress. Microfluidics has nonetheless had a significant impact in fundamental biological studies with model organisms [4, 5]. In this article, we provide an overview of the current state of the field, the impacts of microfluidics in model organism research, and the outlook, challenges, and opportunities for the future.

Keywords

Microfluidics Model organisms Quantitative biology Microscopy Phenotypes Genetics High-throughput High-content Screens 

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Interdisciplinary Program of BioengineeringGeorgia Institute of TechnologyAtlantaUSA
  2. 2.School of Chemical and Biomolecular EngineeringGeorgia Institute of TechnologyAtlantaUSA
  3. 3.Department of Chemical and Biomolecular EngineeringNorth Carolina State UniversityRaleighUSA

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