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Diagnosis and Management of Hereditary Pancreatic Cancer

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Rare Hereditary Cancers

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 205))

Abstract

Hereditary pancreatic cancer can be diagnosed through family history and/or a personal history of pancreatitis or clinical features suggesting one of the known pancreatic cancer predisposition syndromes. This chapter describes the currently known hereditary pancreatic cancer predisposition syndromes, including Peutz–Jeghers syndrome, familial atypical multiple mole melanoma, hereditary breast and ovarian cancer, Li–Fraumeni syndrome, hereditary non-polyposis colon cancer and familial adenomatous polyposis. Strategies for genetic testing for hereditary pancreatic cancer and the appropriate options for surveillance and cancer risk reduction are discussed. Finally, ongoing research and future directions in the diagnosis and management of hereditary pancreatic cancer will be considered.

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Authors and Affiliations

  1. The Kinghorn Cancer Centre, Cancer Research Program, 370 Victoria St., Darlinghurst, NSW, 2010, Australia

    Jeremy L. Humphris & Andrew V. Biankin

  2. Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, Bearsden, G61 1BD, United Kingdom

    Andrew V. Biankin

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  1. Jeremy L. Humphris
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  2. Andrew V. Biankin
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Correspondence to Jeremy L. Humphris .

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Editors and Affiliations

  1. London Bridge Hospital, London, United Kingdom

    Gabriella Pichert

  2. University College London, Guy’s & St Thomas’ NHS Foundation Trust, London, United Kingdom

    Chris Jacobs

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Humphris, J.L., Biankin, A.V. (2016). Diagnosis and Management of Hereditary Pancreatic Cancer. In: Pichert, G., Jacobs, C. (eds) Rare Hereditary Cancers. Recent Results in Cancer Research, vol 205. Springer, Cham. https://doi.org/10.1007/978-3-319-29998-3_5

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  • DOI: https://doi.org/10.1007/978-3-319-29998-3_5

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