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FKBP5 Epialleles

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Book cover Epigenetics and Neuroendocrinology

Part of the book series: Epigenetics and Human Health ((EHH))

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Abstract

Neuroendocrine regulation of the hypothalamic-pituitary-adrenal (HPA) axis relies on the fine-tuned interplay of a multitude of molecular players. The glucocorticoid receptor (GR) takes the central stage in balancing the activity of the HPA axis through its negative feedback on the peptides corticotrophin-releasing hormone and adrenocorticotropic hormone. The activity of GR, in turn, is also controlled by several cofactors including FK506-binding protein 51 (FKBP51) that emerged as potent inhibitory protein of GR. Polymorphisms of its gene FKBP5 have been consistently linked to stress-related diseases such as major depression post-traumatic stress disorder and other neuropsychiatric phenotypes. In addition, recent studies showed that polymorphisms of FKBP5 could also be linked to epigenetic changes evoked in response to stress exposure, giving rise to “epialleles.” Here we present and discuss FKBP5 as stress reactivity gene describing the molecular genetics and epigenetics of FKBP5 and illustrate FKBP5 as a model at the interface of genetics, epigenetics, and neuroendocrinology.

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Authors and Affiliations

  1. McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA, 02478, USA

    Torsten Klengel

  2. Max Planck Institute of Psychiatry, Translational Research in Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany

    Theo Rein

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  1. Torsten Klengel
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  2. Theo Rein
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Correspondence to Torsten Klengel .

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Editors and Affiliations

  1. Translational Res. in Psychiatry, Max Planck Institute of Psychiatry, Munich, Bayern, Germany

    Dietmar Spengler

  2. Translational Res. in Psychiatry, Max Planck Institute of Psychiatry, Munich, Bayern, Germany

    Elisabeth Binder

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Klengel, T., Rein, T. (2016). FKBP5 Epialleles. In: Spengler, D., Binder, E. (eds) Epigenetics and Neuroendocrinology . Epigenetics and Human Health. Springer, Cham. https://doi.org/10.1007/978-3-319-29901-3_1

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