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Oral Cancer

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Oral cancer imposes a significant burden on public health in the USA and many parts of the world. The morbidity of the disease and its treatment can be quite substantial, resulting in disfigurement, pain, impaired speech and swallowing, and overall decreased quality of life. Unfortunately, overall 5-year survival remains approximately 50 %, which has not improved significantly over time despite technological advances in treatment. This chapter outlines the epidemiology, major known risk factors, and clinical features of oral malignant and premalignant lesions as well as management guidelines.


  • Oral cancer
  • Squamous cell carcinoma
  • Carcinogen
  • Smokeless tobacco
  • Synergistic effect
  • Betel
  • Dyskeratosis congenita
  • Fanconi anemia
  • Plummer–Vinson syndrome
  • Sanguinaria
  • Exophytic
  • Tobacco
  • Alcohol
  • Fixation
  • Induration
  • Verrucous carcinoma
  • Dysplasia
  • Carcinoma in situ
  • Cytology
  • Biopsy
  • Actinic cheilitis
  • Leukoplakia
  • Erythroplakia
  • Proliferative verrucous leukoplakia
  • Tobacco pouch keratosis
  • Oral submucous fibrosis
  • Lichen planus
  • Cancer staging
  • Metastasis
  • Mucositis
  • Osteoradionecrosis
  • Xerostomia
  • Radiation therapy
  • Chemotherapy
  • Hyperbaric oxygen therapy

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  • DOI: 10.1007/978-3-319-29767-5_9
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Bruch, J.M., Treister, N.S. (2017). Oral Cancer. In: Clinical Oral Medicine and Pathology. Springer, Cham.

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