Oral Cancer

  • Jean M. Bruch
  • Nathaniel S. Treister


Oral cancer imposes a significant burden on public health in the USA and many parts of the world. The morbidity of the disease and its treatment can be quite substantial, resulting in disfigurement, pain, impaired speech and swallowing, and overall decreased quality of life. Unfortunately, overall 5-year survival remains approximately 50 %, which has not improved significantly over time despite technological advances in treatment. This chapter outlines the epidemiology, major known risk factors, and clinical features of oral malignant and premalignant lesions as well as management guidelines.


Oral cancer Squamous cell carcinoma Carcinogen Smokeless tobacco Synergistic effect Betel Dyskeratosis congenita Fanconi anemia Plummer–Vinson syndrome Sanguinaria Exophytic Tobacco Alcohol Fixation Induration Verrucous carcinoma Dysplasia Carcinoma in situ Cytology Biopsy Actinic cheilitis Leukoplakia Erythroplakia Proliferative verrucous leukoplakia Tobacco pouch keratosis Oral submucous fibrosis Lichen planus Cancer staging Metastasis Mucositis Osteoradionecrosis Xerostomia Radiation therapy Chemotherapy Hyperbaric oxygen therapy 


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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  • Jean M. Bruch
    • 1
  • Nathaniel S. Treister
    • 2
  1. 1.Massachusetts Eye & Ear InfirmaryHarvard Medical SchoolBostonUSA
  2. 2.Brigham & Women’s Hospital Dana-Farber Cancer Institute Harvard School of Dental MedicineBostonUSA

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