Oral Sequelae of Cancer Therapy

  • Jean M. Bruch
  • Nathaniel S. Treister


Patients undergoing cancer therapy are at risk of developing a wide range of acute and late treatment-related toxicities and complications. Depending on the type and location of cancer as well as the treatment modality, the oral cavity may be at significant risk for development of complications. Acute oral toxicities, when severe, may contribute to the need for treatment breaks and/or dose reductions, which can negatively impact clinical outcomes. Late complications contribute to morbidity and reduced quality of life, and in some cases may be life-threatening. Management of an individual patient requires an understanding of risks specific to the cancer and planned therapy, the epidemiology and clinical features of potential complications, and the principles of diagnosis and management.


Oral sequelae Cancer therapy Oral toxicities Oral care Mucositis Osteonecrosis 


  1. Elad S, Raber-Durlacher JE, Brennan MT, et al. Basic oral care for hematology-oncology patients and hematopoietic stem cell transplantation recipients: a position paper from the joint task force of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT). Support Care Cancer. 2015;23:223–36.CrossRefPubMedGoogle Scholar
  2. Epstein JB, Raber-Durlacher JE, Wilkins A, et al. Advances in hematologic stem cell transplant: an update for oral health care providers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107(3):301–12.CrossRefPubMedGoogle Scholar
  3. Hölttä P, Alaluusua S, Saarinen-Pihkala UM, et al. Agenesis and microdontia of permanent teeth as late adverse effects after stem cell transplantation in young children. Cancer. 2005;103:181–90.CrossRefPubMedGoogle Scholar
  4. Pilotte AP, Hohos MB, Polson KM, et al. Managing stomatitis in patients treated with mammalian target of rapamycin inhibitors. Clin J Oncol Nurs. 2011;15:E83–9.CrossRefPubMedGoogle Scholar
  5. Ruggiero SL, Dodson TB, Fantasia J, et al. American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw—2014 update. J Oral Maxillofac Surg. 2014;72:1938–56.CrossRefPubMedGoogle Scholar
  6. Treister N, Duncan C, Cutler C, et al. How we treat oral chronic graft-versus-host disease. Blood. 2012;120:3407–18.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  • Jean M. Bruch
    • 1
  • Nathaniel S. Treister
    • 2
  1. 1.Massachusetts Eye & Ear InfirmaryHarvard Medical SchoolBostonUSA
  2. 2.Brigham & Women’s Hospital Dana-Farber Cancer Institute Harvard School of Dental MedicineBostonUSA

Personalised recommendations