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Oral Manifestations of Systemic Disease

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Lesions inside the oral cavity can be associated with a number of systemic conditions, representing important indicators of active disease or heralding the onset of disease. Recognition of such lesions may facilitate prompt diagnosis and treatment of underlying disease with overall improvement in patients’ quality of life. In some cases, oral findings persist despite adequate systemic management of disease, necessitating targeted ancillary care measures. This chapter reviews the presentation and management of oral findings that may be seen in association with systemic conditions, including autoimmune, gastrointestinal, and granulomatous disorders.


  • Systemic lupus erythematosus
  • Lichenoid inflammation
  • Sjögren syndrome
  • Discoid lupus
  • Scleroderma
  • Graft-versus-host disease
  • Inflammatory bowel disease
  • Crohn disease
  • Angular cheilitis
  • Orofacial granulomatosis
  • Ulcerative colitis
  • Pyostomatitis vegetans
  • Gardner syndrome
  • Peutz-Jeghers syndrome
  • Wegener granulomatosis
  • Antineutrophilic cytoplasmic antibody
  • Sarcoidosis
  • Heerfordt syndrome
  • Angiotensin converting enzyme
  • Human immunodeficiency syndrome
  • Iron deficiency anemia
  • Plummer-Vinson syndrome
  • Pernicious anemia
  • Intrinsic factor
  • Thrombocytopenia
  • Cyclic neutropenia
  • Lymphoma
  • Midline lethal granuloma
  • Leukemia
  • Cowden syndrome
  • Jaundice
  • Bisphosphonate-associated osteonecrosis
  • Sequestra

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  • DOI: 10.1007/978-3-319-29767-5_11
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Bruch, J.M., Treister, N.S. (2017). Oral Manifestations of Systemic Disease. In: Clinical Oral Medicine and Pathology. Springer, Cham.

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