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Contribution and Regulation of Calcium Channels in Endothelial Cells

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Vascular Ion Channels in Physiology and Disease

Abstract

The endothelium is a highly metabolically active organ that plays a pivotal role in many physiological processes. Endothelial cells express a diversity of calcium-permeable ion channels that can be activated in response to a variety of stimuli including Ca2+ store depletion, oxidative stress, growth factors, and endotoxins. Emerging evidences have implicated the critical requirement of Ca2+ signaling in numerous vascular functions including vasomotor tone, barrier function, leukocyte homing and adhesion, inflammation, and hemostasis. The goal of this chapter is to present a comprehensive review of the expression and regulatory mechanisms of Ca2+ channels in endothelial cells, and discuss their contribution to vascular endothelial cell physiology and pathophysiology processes.

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Acknowledgement

We thank Kit Man Tsang for manuscript editing and Katrian Cheng for support. This work was supported by NIH grant HL077806 to A.B.M.

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  1. Department of Pharmacology, College of Medicine, University of Illinois, 835 South Wolcott Ave, MSB, Chicago, IL, 60610, USA

    Kwong Tai Cheng, Avia Rosenhouse-Dantsker & Asrar B. Malik

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  1. Kwong Tai Cheng
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  2. Avia Rosenhouse-Dantsker
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Correspondence to Asrar B. Malik .

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Editors and Affiliations

  1. University of Illinois at Chicago, Chicago, Illinois, USA

    Irena Levitan, PhD

  2. The University of Tennessee, Memphis, Tennessee, USA

    Alex M. Dopico, MD, PhD

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Cheng, K.T., Rosenhouse-Dantsker, A., Malik, A.B. (2016). Contribution and Regulation of Calcium Channels in Endothelial Cells. In: Levitan, PhD, I., Dopico, MD, PhD, A. (eds) Vascular Ion Channels in Physiology and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-29635-7_2

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